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Published in: Intensive Care Medicine 10/2008

01-10-2008 | Review

Automating the weaning process with advanced closed-loop systems

Authors: Karen E. A. Burns, Francois Lellouche, Martin R. Lessard

Published in: Intensive Care Medicine | Issue 10/2008

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Abstract

Background

Limiting the duration of invasive ventilation is an important goal in caring for critically ill patients. Several clinical trials have shown that compared to traditional care, protocols can reduce the total duration of mechanical ventilation. Computerized or automated weaning has the potential to improve weaning, while decreasing associated workload, and to transfer best evidence into clinical practice by integrating closed-loop technology into protocols that can be operationalized continuously.

Discussion

In this article, we review the principles of automated systems, discuss automated systems that can be used during weaning, and examine the best-current evidence from randomized trials and observational studies supporting their use. We highlight three commercially available systems (Mandatory Minute Ventilation, Adaptive Support Ventilation and SmartCare™) that can be used to automate the weaning process. We note advantages and disadvantages associated with individual weaning systems and differences among them.

Conclusions

We discuss the potential role for automation in complimenting clinical acumen, reducing practice pattern variation and facilitating knowledge translation into clinical practice, and underscore the need for additional high quality investigations to evaluate automated weaning systems in different practice settings and diverse patient populations.
Literature
1.
go back to reference Esteban A, Alia I, Ibanez J, Benito S, Tobin MJ (1994) Modes of mechanical ventilation and weaning. A national survey of Spanish hospitals. The Spanish Lung Failure Collaborative Group. Chest 106:1188–1193PubMedCrossRef Esteban A, Alia I, Ibanez J, Benito S, Tobin MJ (1994) Modes of mechanical ventilation and weaning. A national survey of Spanish hospitals. The Spanish Lung Failure Collaborative Group. Chest 106:1188–1193PubMedCrossRef
2.
go back to reference Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ, Mechanical Ventilation International Study Group (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345–355PubMedCrossRef Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ, Mechanical Ventilation International Study Group (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345–355PubMedCrossRef
3.
go back to reference Pingleton SK (1988) Complications of acute respiratory failure. Am Rev Respir Dis 137:1463–1493PubMed Pingleton SK (1988) Complications of acute respiratory failure. Am Rev Respir Dis 137:1463–1493PubMed
4.
go back to reference Dasta JF, McLaughlin TP, Mody SH, Tak Piech C (2005) Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med 33:1266–1271PubMedCrossRef Dasta JF, McLaughlin TP, Mody SH, Tak Piech C (2005) Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med 33:1266–1271PubMedCrossRef
5.
go back to reference MacIntyre NR, Cook DJ, Ely EW Jr, Epstein SK, Fink JB, Heffner JE, Hes D, Hubmayer RD, Scheinhorn DJ, American College of Chest Physicians, American Association for Respiratory Care, American College of Critical Care Medicine (2001) Evidence-based guidelines for weaning and discontinuing ventilator support. A collective task force facilitated by the American College of Chest Physicians, the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest 120(6 Suppl):375S–395SPubMedCrossRef MacIntyre NR, Cook DJ, Ely EW Jr, Epstein SK, Fink JB, Heffner JE, Hes D, Hubmayer RD, Scheinhorn DJ, American College of Chest Physicians, American Association for Respiratory Care, American College of Critical Care Medicine (2001) Evidence-based guidelines for weaning and discontinuing ventilator support. A collective task force facilitated by the American College of Chest Physicians, the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest 120(6 Suppl):375S–395SPubMedCrossRef
6.
go back to reference Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, Johnson MM, Browder RW, Bowton DL, Haponik EF (1996) Effect of the duration of mechanical ventilation on identifying patients capable of breathing spontaneously. N Engl J Med 335:1864–1869PubMedCrossRef Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, Johnson MM, Browder RW, Bowton DL, Haponik EF (1996) Effect of the duration of mechanical ventilation on identifying patients capable of breathing spontaneously. N Engl J Med 335:1864–1869PubMedCrossRef
7.
go back to reference Kollef MH, Shapiro SD, Silver P, St John RE, Prentice D, Sauer S, Ahrens TS, Shannon W, Baker-Clinkscale D (1997) A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med 25:567–574PubMedCrossRef Kollef MH, Shapiro SD, Silver P, St John RE, Prentice D, Sauer S, Ahrens TS, Shannon W, Baker-Clinkscale D (1997) A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med 25:567–574PubMedCrossRef
8.
go back to reference Marelich GP, Murin S, Battistella F, Inciardi J, Vierra T, Roby M (2000) Protocol weaning of mechanical ventilation in medical and surgical patients by respiratory care practitioners and nurses. Effect on weaning time and incidence of ventilator associated pneumonia. Chest 118:459–467PubMedCrossRef Marelich GP, Murin S, Battistella F, Inciardi J, Vierra T, Roby M (2000) Protocol weaning of mechanical ventilation in medical and surgical patients by respiratory care practitioners and nurses. Effect on weaning time and incidence of ventilator associated pneumonia. Chest 118:459–467PubMedCrossRef
9.
go back to reference Esteban A, Alia I, Gordo F, Fernandez R, Solsona JF, Vallverdu I, Macias S, Allegue JM, Blanco J, Carriedo D, Leon M, de la Cal MA, Taboada F, Gonzalez de Velasco J, Palazon E, Carrizosa F, Tomas R, Suarez J, Goldwasser RS (1997) Extubation outcome after spontaneous breathing trials with t-tube or pressure support ventilation. Am J Respir Crit Care Med 156:459–465PubMed Esteban A, Alia I, Gordo F, Fernandez R, Solsona JF, Vallverdu I, Macias S, Allegue JM, Blanco J, Carriedo D, Leon M, de la Cal MA, Taboada F, Gonzalez de Velasco J, Palazon E, Carrizosa F, Tomas R, Suarez J, Goldwasser RS (1997) Extubation outcome after spontaneous breathing trials with t-tube or pressure support ventilation. Am J Respir Crit Care Med 156:459–465PubMed
10.
go back to reference Esteban A, Alia I, Tobin MJ (1999) Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Am J Respir Crit Care Med 159:512–518PubMed Esteban A, Alia I, Tobin MJ (1999) Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Am J Respir Crit Care Med 159:512–518PubMed
11.
go back to reference Perren A, Domenighetti G, Mauri S, Genini F, Vizzardi N (2002) Protocol-directed weaning from mechanical ventilation; clinical outcome in patients randomized for a 30-minute and 120-minute trial with pressure support. Intensive Care Med 28:1058–1063PubMedCrossRef Perren A, Domenighetti G, Mauri S, Genini F, Vizzardi N (2002) Protocol-directed weaning from mechanical ventilation; clinical outcome in patients randomized for a 30-minute and 120-minute trial with pressure support. Intensive Care Med 28:1058–1063PubMedCrossRef
12.
go back to reference Brochard L, Rauss A, Benito S, Conti G, Mancebo J, Rekik N, Gasparetto A, Lemaire F (1994) Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 150:896–903PubMed Brochard L, Rauss A, Benito S, Conti G, Mancebo J, Rekik N, Gasparetto A, Lemaire F (1994) Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 150:896–903PubMed
13.
go back to reference Esteban A, Frutos F, Tobin MJ, Alia I, Solsona JF, Valverdu I, Fernandez R, de la Cal MA, Benito S, Tomas R, Carriedo D, Macias S, Blanco J, for the Spanish Lung Failure Collaborative Group (1995) A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med 332:345–350PubMedCrossRef Esteban A, Frutos F, Tobin MJ, Alia I, Solsona JF, Valverdu I, Fernandez R, de la Cal MA, Benito S, Tomas R, Carriedo D, Macias S, Blanco J, for the Spanish Lung Failure Collaborative Group (1995) A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med 332:345–350PubMedCrossRef
14.
go back to reference Esen F, Denkel T, Telci L, Kesecioglu J, Tutuncu AS, Akpir K, Lachmann B (1992) Comparison of pressure support ventilation and intermittent mandatory ventilation during weaning in patients with acute respiratory failure. Adv Exp Med Biol 317:371–376PubMed Esen F, Denkel T, Telci L, Kesecioglu J, Tutuncu AS, Akpir K, Lachmann B (1992) Comparison of pressure support ventilation and intermittent mandatory ventilation during weaning in patients with acute respiratory failure. Adv Exp Med Biol 317:371–376PubMed
15.
go back to reference Namen AM, Ely EW, Tatter SB, Case LD, Lucia MA, Smith A, Landry S, Wilson JA, Glazier SS, Branch CL, Kelly DL, Bowton DL, Haponik EF (2001) Predicators of successful extubation in neurosurgical patients. Am J Respir Critic Care Med 163:658–664 Namen AM, Ely EW, Tatter SB, Case LD, Lucia MA, Smith A, Landry S, Wilson JA, Glazier SS, Branch CL, Kelly DL, Bowton DL, Haponik EF (2001) Predicators of successful extubation in neurosurgical patients. Am J Respir Critic Care Med 163:658–664
16.
go back to reference Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH, Pediatric Acute Lung Injury, Sepsis Investigators (PALISI) Network (2002) Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA 288:2561–2568PubMedCrossRef Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH, Pediatric Acute Lung Injury, Sepsis Investigators (PALISI) Network (2002) Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA 288:2561–2568PubMedCrossRef
17.
go back to reference Krishnan JA, Moore D, Robeson C, Rand CS, Fessler HE (2004) A prospective, controlled trial of a protocol-based strategy to discontinue mechanical ventilation. Am J Respir Crit Care Med 169:673–678PubMedCrossRef Krishnan JA, Moore D, Robeson C, Rand CS, Fessler HE (2004) A prospective, controlled trial of a protocol-based strategy to discontinue mechanical ventilation. Am J Respir Crit Care Med 169:673–678PubMedCrossRef
18.
go back to reference Ely EW, Bennett PA, Bowton DL, Murphy SM, Florance AM, Haponik EF (1999) Large scale implementation of a respiratory therapist-driven protocol for ventilator weaning. Am J Respir Crit Care Med 159:439–446PubMed Ely EW, Bennett PA, Bowton DL, Murphy SM, Florance AM, Haponik EF (1999) Large scale implementation of a respiratory therapist-driven protocol for ventilator weaning. Am J Respir Crit Care Med 159:439–446PubMed
19.
go back to reference Vitacca M, Clini E, Porta R, Ambrosino N (2000) Preliminary results on nursing workload in a dedicated weaning center. Intensive Care Med 26:796–799PubMedCrossRef Vitacca M, Clini E, Porta R, Ambrosino N (2000) Preliminary results on nursing workload in a dedicated weaning center. Intensive Care Med 26:796–799PubMedCrossRef
20.
go back to reference Chatburn RL (2004) Computer control of mechanical ventilation. Respir Care 49:507–517PubMed Chatburn RL (2004) Computer control of mechanical ventilation. Respir Care 49:507–517PubMed
21.
go back to reference Brunner JX (2001) Principles and history of closed-loop controlled ventilation. Respir Care Clin N Am 7:341–362PubMedCrossRef Brunner JX (2001) Principles and history of closed-loop controlled ventilation. Respir Care Clin N Am 7:341–362PubMedCrossRef
22.
go back to reference Hewlett AM, As Platt, Terry VG (1977) Mandatory minute volume. A new concept in weaning from mechanical ventilation. Anaesthesia 32:163–169PubMedCrossRef Hewlett AM, As Platt, Terry VG (1977) Mandatory minute volume. A new concept in weaning from mechanical ventilation. Anaesthesia 32:163–169PubMedCrossRef
23.
go back to reference Cameron PD, Oh TE (1986) Newer modes of mechanical ventilatory support. Anaesth Intensive Care 14:258–266PubMed Cameron PD, Oh TE (1986) Newer modes of mechanical ventilatory support. Anaesth Intensive Care 14:258–266PubMed
24.
go back to reference Davis S, Potgieter PD, Linton DM (1989) Mandatory minute volume weaning in patients with pulmonary pathology. Anaest Intensive Care 17:170–174 Davis S, Potgieter PD, Linton DM (1989) Mandatory minute volume weaning in patients with pulmonary pathology. Anaest Intensive Care 17:170–174
25.
go back to reference Claure N, Gerhardt T, Hummler H, Everett R, Bancalari E (1997) Computer-controlled minute ventilation in preterm infants undergoing mechanical ventilation. J Pediatrics 131:910–913CrossRef Claure N, Gerhardt T, Hummler H, Everett R, Bancalari E (1997) Computer-controlled minute ventilation in preterm infants undergoing mechanical ventilation. J Pediatrics 131:910–913CrossRef
26.
go back to reference Guthrie SO, Lynn C, Lafleur BJ, Donn SM, Walsh WF (2005) A crossover analysis of mandatory minute ventilation compared to synchronized intermittent mandatory ventilation in neonates. J Perinatol 25:643–646PubMedCrossRef Guthrie SO, Lynn C, Lafleur BJ, Donn SM, Walsh WF (2005) A crossover analysis of mandatory minute ventilation compared to synchronized intermittent mandatory ventilation in neonates. J Perinatol 25:643–646PubMedCrossRef
27.
go back to reference Laubscher TP, Heinrichs W, Weiler N, Hartmann G, Brunner JX (1994) An adaptive lung ventilation controller. IEEE Trans Biomed Eng 41:51–59PubMedCrossRef Laubscher TP, Heinrichs W, Weiler N, Hartmann G, Brunner JX (1994) An adaptive lung ventilation controller. IEEE Trans Biomed Eng 41:51–59PubMedCrossRef
28.
go back to reference Laubscher TP, Frutiger A, Fanconi S, Jutzi H, Brunner JX (1994) Automatic selection of tidal volume, respiratory frequency and minute ventilation in intubated ICU patients as start up procedure for closed-loop controlled ventilation. Int J Clin Monit Comput 11:19–30PubMedCrossRef Laubscher TP, Frutiger A, Fanconi S, Jutzi H, Brunner JX (1994) Automatic selection of tidal volume, respiratory frequency and minute ventilation in intubated ICU patients as start up procedure for closed-loop controlled ventilation. Int J Clin Monit Comput 11:19–30PubMedCrossRef
29.
go back to reference Otis AB, Fenn WO, Rahn H (1950) Mechanics of breathing in man. J Appl Physiol 2:592–607PubMed Otis AB, Fenn WO, Rahn H (1950) Mechanics of breathing in man. J Appl Physiol 2:592–607PubMed
30.
go back to reference Brunner JX, Laubscher TP, Banner MJ, Iotti G, Braschi A (1995) Simple method to measure total expiratory time constant based on the passive expiratory flow-volume curve. Crit Care Med 23:1117–1122PubMedCrossRef Brunner JX, Laubscher TP, Banner MJ, Iotti G, Braschi A (1995) Simple method to measure total expiratory time constant based on the passive expiratory flow-volume curve. Crit Care Med 23:1117–1122PubMedCrossRef
31.
go back to reference Sulzer CF, Chiolero R, Chassot PG, Mueller XM, Revelly JP (2001) Adaptive support ventilation for fast tracheal extubation after cardiac surgery: a randomized controlled study. Anesthesiology 95:1339–1345PubMedCrossRef Sulzer CF, Chiolero R, Chassot PG, Mueller XM, Revelly JP (2001) Adaptive support ventilation for fast tracheal extubation after cardiac surgery: a randomized controlled study. Anesthesiology 95:1339–1345PubMedCrossRef
32.
go back to reference Petter AH, Chiolero RL, Cassina T, Chassot PG, Muller XM, Revelly JP (2003) Automatic “respirator weaning” with adaptive support ventilation: the effect on duration of endotracheal intubation and patient management. Anesth Analg 97:1743–1750PubMedCrossRef Petter AH, Chiolero RL, Cassina T, Chassot PG, Muller XM, Revelly JP (2003) Automatic “respirator weaning” with adaptive support ventilation: the effect on duration of endotracheal intubation and patient management. Anesth Analg 97:1743–1750PubMedCrossRef
33.
go back to reference Linton DM, Potgieter PD, Davis S, Fourie AT, Brunner JX, Laubscher TP (1994) Automatic weaning from mechanical ventilation using an adaptive lung ventilation controller. Chest 106:1843–1850PubMedCrossRef Linton DM, Potgieter PD, Davis S, Fourie AT, Brunner JX, Laubscher TP (1994) Automatic weaning from mechanical ventilation using an adaptive lung ventilation controller. Chest 106:1843–1850PubMedCrossRef
34.
go back to reference Linton DM, Renov G, Lafair J, Vasiliev L, Friedman G (2006) Adaptive Support Ventilation as the sole mode of ventilatory support in chronically ventilated patients. Crit Care Resusc 8:11–14PubMed Linton DM, Renov G, Lafair J, Vasiliev L, Friedman G (2006) Adaptive Support Ventilation as the sole mode of ventilatory support in chronically ventilated patients. Crit Care Resusc 8:11–14PubMed
35.
go back to reference Cassina T, Chiolero R, Mauri R, Revelly JP (2003) Clinical experience with adaptive support ventilation for fast-track cardiac surgery. J Cardiothorac Vasc Anesth 17:571–575PubMedCrossRef Cassina T, Chiolero R, Mauri R, Revelly JP (2003) Clinical experience with adaptive support ventilation for fast-track cardiac surgery. J Cardiothorac Vasc Anesth 17:571–575PubMedCrossRef
36.
go back to reference Arnal JM, Wysocki M, Nafti C, Donati S, Granier I, Corno G, Durand-Gasselin J (2008) Automatic selection of breathing pattern using adaptive support ventilation. Intensive Care Med 34:75–81PubMedCrossRef Arnal JM, Wysocki M, Nafti C, Donati S, Granier I, Corno G, Durand-Gasselin J (2008) Automatic selection of breathing pattern using adaptive support ventilation. Intensive Care Med 34:75–81PubMedCrossRef
37.
go back to reference SmartCare™PS (2005) Knowledge-based system for clinical guidelines Software 1.1. Addendum to Operating Instructions Evita XL Software 6.0 or higher. Draeger Medical AG and Co, KGaA. SmartCare™PS (2005) Knowledge-based system for clinical guidelines Software 1.1. Addendum to Operating Instructions Evita XL Software 6.0 or higher. Draeger Medical AG and Co, KGaA.
38.
go back to reference Bouadma L, Lellouche F, Cabello B, Taille S, Mancebo J, Dojat M, Brochard L (2005) Computer driven management of prolonged mechanical ventilation and weaning: a pilot study. Intensive Care Med 31:1446–1450PubMedCrossRef Bouadma L, Lellouche F, Cabello B, Taille S, Mancebo J, Dojat M, Brochard L (2005) Computer driven management of prolonged mechanical ventilation and weaning: a pilot study. Intensive Care Med 31:1446–1450PubMedCrossRef
39.
go back to reference Jaber S, Pigeot J, Fodil R, Maggiore S, Harf A, Isabey D, Brochard L (2004) Long-term effects of different humidification systems on endotracheal tube patency. Anesthesiology 100:782–788PubMedCrossRef Jaber S, Pigeot J, Fodil R, Maggiore S, Harf A, Isabey D, Brochard L (2004) Long-term effects of different humidification systems on endotracheal tube patency. Anesthesiology 100:782–788PubMedCrossRef
40.
go back to reference Boots RL, George N, Faoagali JL, Druery J, Dean K, Heller RF (2006) Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia. Crit Care Med 34:687–693PubMedCrossRef Boots RL, George N, Faoagali JL, Druery J, Dean K, Heller RF (2006) Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia. Crit Care Med 34:687–693PubMedCrossRef
41.
go back to reference Girault C, Breton L, Richard JC, Tamion F, Vandelet P, Aboab J, Leroy J, Bonmarchand G (2003) Mechanical effects of airway humidification devices in difficult to wean patients. Crit Care Med 31:1306–1311PubMedCrossRef Girault C, Breton L, Richard JC, Tamion F, Vandelet P, Aboab J, Leroy J, Bonmarchand G (2003) Mechanical effects of airway humidification devices in difficult to wean patients. Crit Care Med 31:1306–1311PubMedCrossRef
42.
go back to reference Iotti GA, Olivei MC, Braschi A (1999) Mechanical effects of heat-moisture exchangers in ventilated patients. Crit Care 3:R77–82PubMedCrossRef Iotti GA, Olivei MC, Braschi A (1999) Mechanical effects of heat-moisture exchangers in ventilated patients. Crit Care 3:R77–82PubMedCrossRef
43.
go back to reference Dojat M, Harf A, Touchard D, Lemaire F, Brochard L (2000) Clinical evaluation of a computer-controlled pressure support mode. Am J Respir Crit Care Med 161(4 Pt 1):1161–1166PubMed Dojat M, Harf A, Touchard D, Lemaire F, Brochard L (2000) Clinical evaluation of a computer-controlled pressure support mode. Am J Respir Crit Care Med 161(4 Pt 1):1161–1166PubMed
44.
go back to reference Dojat M, Harf A, Touchard D, Laforest M, Lemaire F, Brochard L (1996) Evaluation of a knowledge-based system providing ventilatory management and decision for extubation. Am J Respir Crit Care Med 153:997–1004PubMed Dojat M, Harf A, Touchard D, Laforest M, Lemaire F, Brochard L (1996) Evaluation of a knowledge-based system providing ventilatory management and decision for extubation. Am J Respir Crit Care Med 153:997–1004PubMed
45.
go back to reference Bouadma L, Lellouche F, Cabello B, Porta V, Deye N, Levy S, Mancebo J, Brochard L (2002) Use of an automated control system to adapt the level of pressure support and manage weaning. Intensive Care Med 28:S23 Bouadma L, Lellouche F, Cabello B, Porta V, Deye N, Levy S, Mancebo J, Brochard L (2002) Use of an automated control system to adapt the level of pressure support and manage weaning. Intensive Care Med 28:S23
46.
go back to reference Lellouche F, Mancebo J, Jolliet P, Roeseler J, Schortgen F, Dojat M, Cabello B, Bouadma L, Rodriguez P, Maggiore S, Reynaert M, Mersmann S, Brochard L (2006) A multicenter, randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med 174:894–900PubMedCrossRef Lellouche F, Mancebo J, Jolliet P, Roeseler J, Schortgen F, Dojat M, Cabello B, Bouadma L, Rodriguez P, Maggiore S, Reynaert M, Mersmann S, Brochard L (2006) A multicenter, randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med 174:894–900PubMedCrossRef
47.
go back to reference Dojat M, Brochard L, Lemaire F, Harf A (1992) A knowledge-based system for assisted ventilation of patients in intensive care units. Int J Clin Monit Comput 9:239–250PubMedCrossRef Dojat M, Brochard L, Lemaire F, Harf A (1992) A knowledge-based system for assisted ventilation of patients in intensive care units. Int J Clin Monit Comput 9:239–250PubMedCrossRef
48.
go back to reference Dojat M, Pachet F, Guessoum Z, Touchard D, Harf A, Brochard L (1997) NeogGanesh: a working system for the automated control of assisted ventilation in the ICUs. Artif Intell Med 11:97–117PubMedCrossRef Dojat M, Pachet F, Guessoum Z, Touchard D, Harf A, Brochard L (1997) NeogGanesh: a working system for the automated control of assisted ventilation in the ICUs. Artif Intell Med 11:97–117PubMedCrossRef
49.
go back to reference Nemoto T, Hatazakis GE, Thorpe CW, Olivenstein R, Dial S, Bates JH (1999) Automatic control of pressure support mechanical ventilation using fuzzy logic. Am J Respir Crit Care Med 160:550–556PubMed Nemoto T, Hatazakis GE, Thorpe CW, Olivenstein R, Dial S, Bates JH (1999) Automatic control of pressure support mechanical ventilation using fuzzy logic. Am J Respir Crit Care Med 160:550–556PubMed
50.
go back to reference Jaber S, Delay JM, Matecki S, Sebbane M, Eledjam JJ, Brochard L (2005) Volume-guaranteed pressure-support ventilation facing acute changes in ventilatory demand. Intensive Care Med 31:1181–1188PubMedCrossRef Jaber S, Delay JM, Matecki S, Sebbane M, Eledjam JJ, Brochard L (2005) Volume-guaranteed pressure-support ventilation facing acute changes in ventilatory demand. Intensive Care Med 31:1181–1188PubMedCrossRef
51.
go back to reference Sottiaux TM (2001) Patient-ventilator interactions during volume-support ventilation: asynchrony and tidal volume instability—a report of three cases. Respir Care 46:255–262PubMed Sottiaux TM (2001) Patient-ventilator interactions during volume-support ventilation: asynchrony and tidal volume instability—a report of three cases. Respir Care 46:255–262PubMed
52.
go back to reference Branson RD (2001) Dual control modes, closed loop ventilation, handguns and Tequila. Respiratory Care 46:232–233PubMed Branson RD (2001) Dual control modes, closed loop ventilation, handguns and Tequila. Respiratory Care 46:232–233PubMed
Metadata
Title
Automating the weaning process with advanced closed-loop systems
Authors
Karen E. A. Burns
Francois Lellouche
Martin R. Lessard
Publication date
01-10-2008
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 10/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-008-1154-0

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