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Open Access 01-08-2008 | Brief Report

Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery

Authors: Emile F. Schippers, Jimmy F. P. Berbée, Inge M. van Disseldorp, Michael I. M. Versteegh, Louis M. Havekes, Patrick C. N. Rensen, Jaap T. van Dissel

Published in: Intensive Care Medicine | Issue 8/2008

Abstract

Objective

Experimental models show that apolipoprotein CI (apoCI) binds and enhances the inflammatory response to endotoxin. We studied in patients undergoing cardiopulmonary bypass surgery (CPB) and experiencing endotoxemia during reperfusion whether plasma apoCI levels correlate with the inflammatory response and perioperative cytokine release.

Design

Prospective, observational, clinical cohort study.

Setting

Operating room (OR) and intensive care unit (ICU) of a university hospital.

Patients

One hundred fifty-nine consecutive patients > 18 years of age (66% males (n = 105), median age 65 and 67 years for males and females, respectively) undergoing elective cardiothoracic surgery with cardiopulmonary bypass.

Interventions

None.

Measurements

Baseline apoCI, apoCIII, total cholesterol and triglyceride levels, and perioperative endotoxin and TNF-α levels were determined.

Results

High preoperative plasma apoCI, but not apoCIII, levels were associated (p < 0.05) with increased perioperative levels of TNF-α in patients experiencing endotoxemia. This association was not observed in patients without endotoxemia.

Conclusion

High plasma apoCI is positively related to proinflammatory response in patients experiencing endotoxemia and confirms the observations in animal models.

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Title: Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery
Authors: Emile F. Schippers
Jimmy F. P. Berbée
Inge M. van Disseldorp
Michael I. M. Versteegh
Louis M. Havekes
Patrick C. N. Rensen
Jaap T. van Dissel
Publication date: 01-08-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 8/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1077-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery

Abstract

Objective

Design

Setting

Patients

Interventions

Measurements

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Interventions

Measurements

Results

Conclusion

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