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Published in:

01-02-2008 | Original

Do antibiotics administered at the time of central venous catheter removal interfere with the evaluation of colonization?

Authors: Bertrand Souweine, Anne Elisabeth Heng, Claire Aumeran, Fabrice Thiollière, Nicole Gazuy, Patrice Deteix, Ousmane Traoré

Published in: Intensive Care Medicine | Issue 2/2008

Abstract

Objective

Catheter colonization is commonly used as an end point in studies on central venous catheter (CVC) infections. This study aimed at comparing the rates of catheter colonization in patients according to the administration of antibiotics at removal.

Design

Prospective study over a 5-year period. All patients with a CVC removed without suspicion of CVC infection were included.

Setting

An adult medical/surgical intensive care unit at a university teaching hospital.

Patients

A total of 472 patients with CVC inserted for a mean CVC duration of 6.0 ± 3.7 days were included.

Methods

Antibiotics at removal was defined as antibiotics administered within 48 h before CVC removal, and CVC colonization as catheter tip culture yielding ≥ 10³ colony-forming units per milliliter.

Interventions

None.

Measurements and results

Of 472 patients, 302 (64%) were receiving antibiotics at removal. The number of CVC colonizations per number of CVCs inserted was 4.7% (22 of 472) and the number of CVC colonizations per 1000 CVC days was 8.0. Administration of antibiotics at removal was associated with a lower risk of CVC colonization. Irrespective of CVC duration, CVC colonization rate differed between patients with or without antibiotics at removal (Kaplan–Meier test, p = 0.04).

Conclusions

The proportion of patients with antibiotics at time of removal should be taken into account when interpreting the results of surveys and trials using the quantitative CVC tip culture to define CVC colonization as an end point.

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Title: Do antibiotics administered at the time of central venous catheter removal interfere with the evaluation of colonization?
Authors: Bertrand Souweine
Anne Elisabeth Heng
Claire Aumeran
Fabrice Thiollière
Nicole Gazuy
Patrice Deteix
Ousmane Traoré
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 2/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0849-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Do antibiotics administered at the time of central venous catheter removal interfere with the evaluation of colonization?

Abstract

Objective

Design

Setting

Patients

Methods

Interventions

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Methods

Interventions

Measurements and results

Conclusions

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