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Intensive Care Medicine

Published in:

01-09-2007 | Original

B-type natriuretic peptide as a marker for heart failure in patients with acute stroke

Authors: Matthew A. Koenig, H. Adrian Puttgen, Vivek Prabhakaran, Daniel Reich, Robert D. Stevens

Published in: Intensive Care Medicine | Issue 9/2007

Abstract

Objective

To determine whether serum N-terminal pro-B-type natriuretic peptide (N-BNP), a biomarker of myocardial wall stress, is specific to acute heart failure (HF) in patients hospitalized with stroke.

Design

Case-control study.

Setting

Tertiary hospital, Neurosciences Critical Care Unit and Stroke Unit.

Patients

Consecutive patients with acute ischemic or hemorrhagic stroke who were evaluated for HF.

Intervention

None.

Measurements and results

Cases and controls were classified, respectively, as patients with or without HF, defined according to modified Framingham criteria. Seventy-two patients were evaluated, 39 with ischemic stroke, 22 with aneurysmal subarachnoid hemorrhage (SAH), and 11 with intracerebral hemorrhage (ICH). Thirty-four patients (47%) met criteria for HF, and 47 patients (65%) had systolic or diastolic left ventricular (LV) dysfunction on echocardiogram. Serum N-BNP was measured a median of 48 h following the onset of stroke and was increased (> 900 pg/ml) in 56 patients (78%), with higher levels in non-survivors (11898 ± 12741 vs 4073 ± 5691; p = 0.001). In a multiple regression model, N-BNP elevation was not independently associated with HF (OR 5.4, 95% CI 0.8–36.0, p = 0.084). At a cut-off of 900 pg/ml, the sensitivity of N-BNP for HF was 94%, specificity 37%, positive predictive value (PPV) 57%, and negative predictive value (NPV) 88%. For systolic or diastolic LV dysfunction, the sensitivity of N-BNP was 89%, specificity 44%, PPV 75%, and NPV 69%.

Conclusions

These results demonstrate that N-BNP elevation is not specific to HF or LV dysfunction in patients with acute ischemic stroke, SAH, and ICH.

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Title: B-type natriuretic peptide as a marker for heart failure in patients with acute stroke
Authors: Matthew A. Koenig
H. Adrian Puttgen
Vivek Prabhakaran
Daniel Reich
Robert D. Stevens
Publication date: 01-09-2007
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 9/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0704-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

B-type natriuretic peptide as a marker for heart failure in patients with acute stroke

Abstract

Objective

Design

Setting

Patients

Intervention

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Intervention

Measurements and results

Conclusions

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