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01-03-2007 | Experimental

Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock

Authors: Bruno Levy, Arnauld Mansart, Chantal Montemont, Sebastien Gibot, Jean-Pierre Mallie, Veronique Regnault, Thomas Lecompte, Patrick Lacolley

Published in: Intensive Care Medicine | Issue 3/2007

Abstract

Objective

We examined whether lactate availability is a limiting factor for heart function during endotoxic shock, and whether lactate deprivation thus induces heart energy depletion, thereby altering cardiovascular performance. The study goals were to determine whether muscle lactate production is linked to β₂-stimulation and to ascertain the effects of systemic lactate deprivation on hemodynamics, lactate metabolism, heart energetics, and outcome in a lethal model of rat's endotoxic shock.

Interventions

We modulated the adrenergic pathway in skeletal muscle using microdialysis with ICI-118551, a selective β₂-blocker. Muscle lactate formation in endotoxic shock was further inhibited by intravenous infusion of ICI-118551 or dichloroacetate (DCA), an activator of pyruvate dehydrogenase (DCA) and their combination.

Results

Muscle lactate formation was decreased by ICI-118551. During endotoxic shock both ICI-118151 and DCA decreased circulating and heart lactate concentrations in parallel with a decrease in tissue ATP content. The combination ICI-118551-DCA resulted in early cardiovascular collapse and death. The addition of molar lactate to ICI-1185111 plus DCA blunted the effects of ICI-118551+DCA on hemodynamics. Survival was markedly less with ICI-118551 than with endotoxin alone.

Conclusion

Systemic lactate deprivation is detrimental to myocardial energetics, cardiovascular performance, and outcome.

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Title: Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock
Authors: Bruno Levy
Arnauld Mansart
Chantal Montemont
Sebastien Gibot
Jean-Pierre Mallie
Veronique Regnault
Thomas Lecompte
Patrick Lacolley
Publication date: 01-03-2007
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-006-0523-9

2024 ASCO Annual Meeting

Springer Medicine

Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock

Abstract

Objective

Interventions

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objective

Interventions

Results

Conclusion

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