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Intensive Care Medicine

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01-11-2006 | Pediatric Original

Epidemiology and Peculiarities of Pediatric Multiple Organ Dysfunction Syndrome in New Delhi, India

Authors: Praveen Khilnani, Devajit Sarma, Jerry Zimmerman

Published in: Intensive Care Medicine | Issue 11/2006

Abstract

Objective

Most pediatric studies on multiple organ dysfunction syndrome derive from developed countries. There is little information regarding the etiologies and outcomes of multiple organ dysfunction syndrome in critically ill children from developing countries. The objective of this study was to examine the differences in epidemiology of multiple organ dysfunction syndrome and the relationship of the Organ Failure Index (OFI) to outcomes from multiple organ dysfunction syndrome in critically ill children from a developing country.

Design

Prospective observational study.

Setting

A 10-bed tertiary pediatric intensive care unit.

Patients

A total of 1722 children (1 month to 16 years of age) admitted to a pediatric intensive care unit during the study period from January 1998 to June 2003.

Interventions

None.

Measurements and main results

Of all the patients admitted to the pediatric intensive care unit, 184 patients (10.6%) had persistent multiple organ dysfunction syndrome. During the study period 136 deaths (7.9%) occurred in the ICU. Multiple organ dysfunction syndrome was associated with nearly half of these deaths, 67/136 (49.2%). Overall survival of all patients with persistent multiple organ dysfunction syndrome was 64% (117/184). In addition to sepsis, falciparum malaria, fulminant hepatic failure, dengue shock syndrome, severe poisonings, post cardiopulmonary bypass, and post cardiac arrest were significant antecedents of multiple organ dysfunction syndrome . Patients with OFI scores of 2, 3, 4–5, and > 5 exhibited mortalities of 9%, 29%, 58%, and 100% respectively.

Conclusions

In addition to “traditional” sepsis, common etiologies of multiple organ dysfunction syndrome included falciparum malaria, fulminant hepatic failure, and dengue shock syndrome. In developing countries like India, multiple organ dysfunction syndrome carries a significant risk of mortality which is directly related to the OFI.

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Title: Epidemiology and Peculiarities of Pediatric Multiple Organ Dysfunction Syndrome in New Delhi, India
Authors: Praveen Khilnani
Devajit Sarma
Jerry Zimmerman
Publication date: 01-11-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 11/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-006-0373-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Epidemiology and Peculiarities of Pediatric Multiple Organ Dysfunction Syndrome in New Delhi, India

Abstract

Objective

Design

Setting

Patients

Interventions

Measurements and main results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Interventions

Measurements and main results

Conclusions

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