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01-10-2006 | Editorial

The world according to poly(ADP-ribose) polymerase (PARP)—update 2006

Authors: Eberhard Barth, Peter Radermacher, Csaba Szabó

Published in: Intensive Care Medicine | Issue 10/2006

Excerpt

Oxidative stress is characterised by an imbalance between reactive oxygen and nitrogen species (ROS/RNS) and antioxidant defence mechanisms. The overwhelming production of ROS/RNS results in tissue damage, lipid peroxidation of cell membranes, protein oxidation and changes in DNA (strand breaks and base modifications) and represents a major pathway that contributes to the pathogenesis of many acute and chronic diseases, such as ischaemia/reperfusion injury, systemic inflammation/septic shock, diabetes, stroke and arthritis. In this context, a central role is played by peroxynitrite, which is a potent trigger of DNA strand breakage with subsequent activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP). …

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Title: The world according to poly(ADP-ribose) polymerase (PARP)—update 2006
Authors: Eberhard Barth
Peter Radermacher
Csaba Szabó
Publication date: 01-10-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 10/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-006-0336-x

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The world according to poly(ADP-ribose) polymerase (PARP)—update 2006

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