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01-06-2006 | Correspondence

Bronchoalveolar levels of plasminogen activator inhibitor-1 and soluble tissue factor are sensitive and specific markers of pulmonary inflammation

Authors: Rogier M. Determann, Julian L. Millo, Chris S. Garrard, Marcus J. Schultz

Published in: Intensive Care Medicine | Issue 6/2006

Excerpt

Sir: Activation of coagulation and inhibition of fibrinolysis are hallmarks of pulmonary inflammation. Changes in alveolar fibrin turnover have been reported in pneumonia [1, 2, 3] and acute respiratory distress syndrome (ARDS) [1]. Recently in Intensive Care Medicine El Sohl et al. [4] proposed plasminogen activator inhibitor (PAI)-1 as a biomarker of ARDS in patients with aspiration pneumonitis. They reported bronchoalveolar lavage fluid PAI-1 levels in 51 patients with witnessed aspiration who had a PaO₂/FIO₂ ratio lower than 300 mmHg for a period no less than 4 h from admission. PAI-1 antigen levels were more than five times higher in those who progressed to ARDS than in those who did not. …

Gunther A, Mosavi P, Heinemann S, Ruppert C, Muth H, Markart P, Grimminger F, Walmrath D, Temmesfeld-Wollbruck B, Seeger W (2000) Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome. Am J Respir Crit Care Med 161:454–462PubMed

Schultz MJ, Millo J, Levi M, Hack CE, Weverling GJ, Garrard CS, van der Poll T (2004) Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia. Thorax 59:130–135CrossRefPubMed

El Solh AA, Okada M, Pietrantoni C, Aquilina A, Berbary E (2004) Procoagulant and fibrinolytic activity in ventilator-associated pneumonia: impact of inadequate antimicrobial therapy. Intensive Care Med 30:1914–1920CrossRefPubMed

El Solh AA, Bhora M, Pineda L, Aquilina A, Abbetessa L, Berbary E (2005) Alveolar plasminogen activator inhibitor-1 predicts ARDS in aspiration pneumonitis. Intensive Care Med 32:110–115PubMed

Choi G, Schultz MJ, Levi M, van der Poll T, Millo JL, Garrard CS (2005) Protein C in pneumonia. Thorax 60:705–706CrossRefPubMed

Title: Bronchoalveolar levels of plasminogen activator inhibitor-1 and soluble tissue factor are sensitive and specific markers of pulmonary inflammation
Authors: Rogier M. Determann
Julian L. Millo
Chris S. Garrard
Marcus J. Schultz
Publication date: 01-06-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 6/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-006-0167-9

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Bronchoalveolar levels of plasminogen activator inhibitor-1 and soluble tissue factor are sensitive and specific markers of pulmonary inflammation

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