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01-12-2005 | Original

Differential cardiovascular responses during weaning failure: effects on tissue oxygenation and lactate

Authors: Spyros Zakynthinos, Christina Routsi, Theodoros Vassilakopoulos, Panagiotis Kaltsas, Epaminondas Zakynthinos, Danai Kazi, Charis Roussos

Published in: Intensive Care Medicine | Issue 12/2005

Abstract

Objective

To test the following two hypotheses during weaning failure: (a) mixed venous oxygen saturation (SvO₂) does not decrease in patients whose oxygen consumption does not increase, and (b) blood lactate may increase in patients who demonstrate substantial decreases in SvO₂.

Design and setting

A prospective observational and physiological study in a 30-bed university intensive care unit.

Patients and participants

18 patients who failed weaning and 12 patients who succeeded weaning (controls).

Measurements and results

Hemodynamics, global tissue oxygenation, cardiovascular response (cardiac index/oxygen extraction diagram), and blood lactate were measured in ventilator-supported patients undergoing a spontaneous breathing trial. In patients who failed without having increased their oxygen consumption (n=9) the increase in oxygen delivery was accompanied by a decrease in oxygen extraction (by 15±4%). In patients who failed (n=9) having increased their oxygen consumption (by >10%) this increase was met mainly by an increase in oxygen extraction (by 30±7%). SvO₂increased by 2±1% in the former patients, whereas it decreased by 20±5% in the latter. Arterial lactate increased (range 2.3–3.1 mM/l) in only three patients who failed to have increased oxygen consumption and exhibited heart failure and the highest decreases in SvO₂ (by 12–39%).

Conclusions

Patients whose SvO₂ does not decrease during weaning failure do not have increased oxygen consumption probably due to respiratory center depression in some of them. Patients whose SvO₂ decreases have increased oxygen consumption.

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Title: Differential cardiovascular responses during weaning failure: effects on tissue oxygenation and lactate
Authors: Spyros Zakynthinos
Christina Routsi
Theodoros Vassilakopoulos
Panagiotis Kaltsas
Epaminondas Zakynthinos
Danai Kazi
Charis Roussos
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 12/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2699-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Differential cardiovascular responses during weaning failure: effects on tissue oxygenation and lactate

Abstract

Objective

Design and setting

Patients and participants

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients and participants

Measurements and results

Conclusions

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