Top

Published in:

01-08-2005 | Special Article

Inhaled nitric oxide therapy in adults: European expert recommendations

Authors: Peter Germann, Antonio Braschi, Giorgio Della Rocca, Anh Tuan Dinh-Xuan, Konrad Falke, Claes Frostell, Lars E. Gustafsson, Philippe Hervé, Philippe Jolliet, Udo Kaisers, Hector Litvan, Duncan J. Macrae, Marco Maggiorini, Nandor Marczin, Bernd Mueller, Didier Payen, Marco Ranucci, Dietmar Schranz, Rainer Zimmermann, Roman Ullrich

Published in: Intensive Care Medicine | Issue 8/2005

Abstract

Background

Inhaled nitric oxide (iNO) has been used for treatment of acute respiratory failure and pulmonary hypertension since 1991 in adult patients in the perioperative setting and in critical care.

Methods

This contribution assesses evidence for the use of iNO in this population as presented to a expert group jointly organised by the European Society of Intensive Care Medicine and the European Association of Cardiothoracic Anaesthesiologists.

Conclusions

Expert recommendations on the use of iNO in adults were agreed on following presentation of the evidence at the expert meeting held in June 2004.

Higenbottam T, Pepke-Zaba J, Scott J, Woolman P, Coutts C, Wallwork J (1988) Inhaled endothelial derived-relaxing factor (EDRF) in primary pulmonary hypertension (PPH). Am Rev Respir Dis [Suppl]:137:A107

Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J (1991) Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 338:1173–1174PubMed

Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM (1991) Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038–2047PubMed

Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399–405PubMed

Abman SH, Griebel JL, Parker DK, Schmidt JM, Swanton D, Kinsella JP (1994) Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure. J Pediatr 124:881–888PubMed

Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD Jr, Zapol WM (1994) Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology 80:761–770PubMed

Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ (1993) Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 19:443–449PubMed

Puybasset L, Stewart T, Rouby JJ, Cluzel P, Mourgeon E, Belin MF, Arthaud M, Landault C, Viars P (1994) Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 80:1254–1267PubMed

Young JD, Brampton WJ, Knighton JD, Finfer SR (1994) Inhaled nitric oxide in acute respiratory failure in adults. Br J Anaesth 73:499–502

10.

Lundin S, Mang H, Smithies M, Stenqvist O, Frostell C (1999) Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide. Intensive Care Med 25:911–919PubMed

11.

Michael JR, Barton RG, Saffle JR, Mone M, Markewitz BA, Hillier K, Elstad MR, Campbell EJ, Troyer BE, Whatley RE, Liou TG, Samuelson WM, Carveth HJ, Hinson DM, Morris SE, Davis BL, Day RW (1998) Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med 157:1372–1380PubMed

12.

Troncy E, Collet JP, Shapiro S, Guimond JG, Blair L, Ducruet T, Francoeur M, Charbonneau M, Blaise G (1998) Inhaled nitric oxide in acute respiratory distress syndrome: a pilot randomized controlled study. Am J Respir Crit Care Med 157:1483–1488PubMed

13.

Dellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ, Davis K Jr, Hyers TM, Papadakos P (1998) Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 26:15–23PubMed

14.

Gerlach H, Rossaint R, Pappert D, Falke KJ (1993) Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 23:499–502PubMed

15.

Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis K Jr, Kelly KM, Smith TC, Small RJ (2004) Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 291:1603–1609PubMed

16.

Beloucif S, Payen D (1998) A European survey of the use of inhaled nitric oxide in the ICU. Working Group on Inhaled NO in the ICU of the European Society of Intensive Care Medicine. Intensive Care Med 24:864–877PubMed

17.

Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM (1993) Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78:427–435PubMed

18.

Roberts JD Jr, Lang P, Bigatello LM, Vlahakes GJ, Zapol WM (1993) Inhaled nitric oxide in congenital heart disease. Circulation 87:447–453PubMed

19.

Girard C, Lehot JJ, Pannetier JC, Filley S, Ffrench P, Estanove S (1992) Inhaled nitric oxide after mitral valve replacement in patients with chronic pulmonary artery hypertension. Anesthesiology 77:880–883PubMed

20.

Miller OI, Tang SF, Keech A, Celermajer DS (1995) Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet 346:51–52

21.

Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM (1992) Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest 90:421–428PubMed

22.

Hogman M, Frostell CG, Hedenstrom H, Hedenstierna G (1993) Inhalation of nitric oxide modulates adult human bronchial tone. Am Rev Respir Dis 148:1474–1478PubMed

23.

Wraight WM, Young JD (2001) Renal effects of inhaled nitric oxide in humans. Br J Anaesth 86:267–269

24.

Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Westfelt UN, Petersson AS, Waagstein F (1993) Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 73:1121–1127PubMed

25.

Samama CM, Diaby M, Fellahi JL, Mdhafar A, Eyraud D, Arock M, Guillosson JJ, Coriat P, Rouby JJ (1995) Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 83:56–65PubMed

26.

Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S, Walsh-Sukys MC, McCaffrey MJ, Cornfield DN, Bhutani VK, Cutter GR, Baier M, Abman SH (1999) Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 354:1061–1065PubMed

27.

Wan S, LeClerc JL, Vincent JL (1997) Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112:676–692PubMed

28.

Olschewski H, Simonneau G, Galie N, Higenbottam T, Naeije R, Rubin LJ, Nikkho S, Speich R, Hoeper MM, Behr J, Winkler J, Sitbon O, Popov W, Ghofrani HA, Manes A, Kiely DG, Ewert R, Meyer A, Corris PA, Delcroix M, Gomez-Sanchez M, Siedentop H, Seeger W (2002) Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 347:322–329CrossRefPubMed

29.

Ralevic V, Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413–492PubMed

30.

Jolliet P, Bulpa P, Ritz M, Ricou B, Lopez J, Chevrolet JC (1997) Additive beneficial effects of the prone position, nitric oxide, and almitrine bismesylate on gas exchange and oxygen transport in acute respiratory distress syndrome. Crit Care Med 25:786–794PubMed

31.

Lu Q, Mourgeon E, Law-Koune JD, Roche S, Vezinet C, Abdennour L, Vicaut E, Puybasset L, Diaby M, Coriat P et al (1995) Dose-response curves of inhaled nitric oxide with and without intravenous almitrine in nitric oxide-responding patients with acute respiratory distress syndrome. Anesthesiology 83:929–943PubMed

32.

Gillart T, Bazin JE, Cosserant B, Guelon D, Aigouy L, Mansoor O, Schoeffler P (1998) Combined nitric oxide inhalation, prone positioning and almitrine infusion improve oxygenation in severe ARDS. Can J Anaesth 45:402–409PubMed

33.

Germann P, Poschl G, Leitner C, Urak G, Ullrich R, Faryniak B, Roder G, Kaider A, Sladen R (1998) Additive effect of nitric oxide inhalation on the oxygenation benefit of the prone position in the adult respiratory distress syndrome. Anesthesiology 89:1401–1406PubMed

34.

Gallart L, Lu Q, Puybasset L, Umamaheswara Rao GS, Coriat P, Rouby JJ (1998) Intravenous almitrine combined with inhaled nitric oxide for acute respiratory distress syndrome. The NO Almitrine Study Group. Am J Respir Crit Care Med 158:1770–1777PubMed

35.

Ziegler JW, Ivy DD, Wiggins JW, Kinsella JP, Clarke WR, Abman SH (1998) Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension. Am J Respir Crit Care Med 158:1388–1395PubMed

36.

Kuhlen R, Walbert E, Frankel P, Thaden S, Behrendt W, Rossaint R (1999) Combination of inhaled nitric oxide and intravenous prostacyclin for successful treatment of severe pulmonary hypertension in a patient with acute respiratory distress syndrome. Intensive Care Med 25:752–754PubMed

37.

Rialp G, Betbese AJ, Perez-Marquez M, Mancebo J (2001) Short-term effects of inhaled nitric oxide and prone position in pulmonary and extrapulmonary acute respiratory distress syndrome. Am J Respir Crit Care Med 164:243–249PubMed

38.

Macrae DJ, Field D, Mercier JC, Moller J, Stiris T, Biban P, Cornick P, Goldman A, Gothberg S, Gustafsson LE, Hammer J, Lonnqvist PA, Sanchez-Luna M, Sedin G, Subhedar N (2004) Inhaled nitric oxide therapy in neonates and children: reaching a European consensus. Intensive Care Med 30:372–380

39.

Moraes DL, Colucci WS, Givertz MM (2000) Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management. Circulation 102:1718–1723PubMed

40.

Verma S, Anderson TJ (2002) Fundamentals of endothelial function for the clinical cardiologist. Circulation 105:546–549PubMed

41.

Celermajer DS, Cullen S, Deanfield JE (1993) Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 87:440–446PubMed

42.

Bocchi EA, Bacal F, Auler Junior JO, Carmone MJ, Bellotti G, Pileggi F (1994) Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol 74:70–72PubMed

43.

Hare JM, Shernan SK, Body SC, Graydon E, Colucci WS, Couper GS (1997) Influence of inhaled nitric oxide on systemic flow and ventricular filling pressure in patients receiving mechanical circulatory assistance. Circulation 95:2250–2253PubMed

44.

Galie N, Seeger W, Naeije R, Simonneau G, Rubin LJ (2004) Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 43:81S-88SPubMed

45.

Rich S, Kaufmann E, Levy PS (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327:76–81PubMed

46.

Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH et al (1996) A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med 334:296–302CrossRefPubMed

47.

Simonneau G, Barst RJ, Galie N, Naeije R, Rich S, Bourge RC, Keogh A, Oudiz R, Frost A, Blackburn SD, Crow JW, Rubin LJ (2002) Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 165:800–804PubMed

48.

Hoeper MM, Schwarze M, Ehlerding S, Adler-Schuermeyer A, Spiekerkoetter E, Niedermeyer J, Hamm M, Fabel H (2000) Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 342:1866–1870CrossRefPubMed

49.

Simonneau G, Galie N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A (2004) Clinical classification of pulmonary hypertension. J Am Coll Cardiol 43:5S–12SCrossRefPubMed

50.

Morales-Blanhir J, Santos S, de Jover L, Sala E, Pare C, Roca J, Rodriguez-Roisin R, Barbera JA (2004) Clinical value of vasodilator test with inhaled nitric oxide for predicting long-term response to oral vasodilators in pulmonary hypertension. Respir Med 98:225–234PubMed

51.

Leuchte HH, Schwaiblmair M, Baumgartner RA, Neurohr CF, Kolbe T, Behr J (2004) Hemodynamic response to sildenafil, nitric oxide, and iloprost in primary pulmonary hypertension. Chest 125:580–586PubMed

52.

Sablotzki A, Hentschel T, Gruenig E, Schubert S, Friedrich I, Muhling J, Dehne MG, Czeslick E (2002) Hemodynamic effects of inhaled aerosolized iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance. Eur J Cardiothorac Surg 22:746–752PubMed

53.

Loscalzo J (2001) Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 88:756–762PubMed

54.

Kermarrec N, Zunic P, Beloucif S, Benessiano J, Drouet L, Payen D (1998) Impact of inhaled nitric oxide on platelet aggregation and fibrinolysis in rats with endotoxic lung injury. Role of cyclic guanosine 5′-monophosphate. Am J Respir Crit Care Med 158:833–839PubMed

55.

Bottiger BW, Motsch J, Dorsam J, Mieck U, Gries A, Weimann J, Martin E (1996) Inhaled nitric oxide selectively decreases pulmonary artery pressure and pulmonary vascular resistance following acute massive pulmonary microembolism in piglets. Chest 110:1041–1047PubMed

56.

Estagnasie P, Le Bourdelles G, Mier L, Coste F, Dreyfuss D (1994) Use of inhaled nitric oxide to reverse flow through a patent foramen ovale during pulmonary embolism. Ann Intern Med 120:757–759PubMed

57.

Capellier G, Jacques T, Balvay P, Blasco G, Belle E, Barale F (1997) Inhaled nitric oxide in patients with pulmonary embolism. Intensive Care Med 23:1089–1092PubMed

58.

Schenk P, Mittermayer C, Ratheiser K (1999) Inhaled nitric oxide in a patient with severe pulmonary embolism. Ann Emerg Med 33:710–714PubMed

59.

Pinelli G, Mertes PM, Carteaux JP, Hubert T, Dopff C, Burtin P, Villemot JP (1996) Inhaled nitric oxide as an adjunct to pulmonary thromboendarterectomy. Ann Thorac Surg 61:227–229PubMed

60.

Bunn HF (1997) Pathogenesis and treatment of sickle cell disease. N Engl J Med 337:762–769PubMed

61.

Martinez-Ruiz R, Montero-Huerta P, Hromi J, Head CA (2001) Inhaled nitric oxide improves survival rates during hypoxia in a sickle cell (SAD) mouse model. Anesthesiology 94:1113–1118PubMed

62.

Atz AM, Wessel DL (1997) Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology 87:988–990PubMed

63.

Sullivan KJ, Goodwin SR, Evangelist J, Moore RD, Mehta P (1999) Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. Crit Care Med 27:2563–2568PubMed

64.

Weiner DL, Hibberd PL, Betit P, Cooper AB, Botelho CA, Brugnara C (2003) Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA 289:1136–1142PubMed

65.

Adnot S, Kouyoumdjian C, Defouilloy C, Andrivet P, Sediame S, Herigault R, Fratacci MD (1993) Hemodynamic and gas exchange responses to infusion of acetylcholine and inhalation of nitric oxide in patients with chronic obstructive lung disease and pulmonary hypertension. Am Rev Respir Dis 148:310–316PubMed

66.

Barbera JA, Roger N, Roca J, Rovira I, Higenbottam TW, Rodriguez-Roisin R (1996) Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 347:436–440PubMed

67.

Ashutosh K, Phadke K, Jackson JF, Steele D (2000) Use of nitric oxide inhalation in chronic obstructive pulmonary disease. Thorax 55:109–113PubMed

68.

Baigorri F, Joseph D, Artigas A, Blanch L (1999) Inhaled nitric oxide does not improve cardiac or pulmonary function in patients with an exacerbation of chronic obstructive pulmonary disease. Crit Care Med 27:2153–2158PubMed

69.

Vonbank K, Ziesche R, Higenbottam TW, Stiebellehner L, Petkov V, Schenk P, Germann P, Block LH (2003) Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax 58:289–293PubMed

70.

Morita K, Ihnken K, Buckberg GD, Sherman MP, Ignarro LJ (1996) Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass. Ann Thorac Surg 61:1775–1780PubMed

71.

Gianetti J, Del Sarto P, Bevilacqua S, Vassalle C, De Filippis R, Kacila M, Farneti PA, Clerico A, Glauber M, Biagini A (2004) Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation. J Thorac Cardiovasc Surg 127:44–50PubMed

72.

Solina A, Papp D, Ginsberg S, Krause T, Grubb W, Scholz P, Pena LL, Cody R (2000) A comparison of inhaled nitric oxide and milrinone for the treatment of pulmonary hypertension in adult cardiac surgery patients. J Cardiothorac Vasc Anesth 14:12–17PubMed

73.

Schmid ER, Burki C, Engel MH, Schmidlin D, Tornic M, Seifert B (1999) Inhaled nitric oxide versus intravenous vasodilators in severe pulmonary hypertension after cardiac surgery. Anesth Analg 89:1108–1115

74.

Fullerton DA, Jones SD, Jaggers J, Piedalue F, Grover FL, McIntyre RC Jr (1996) Effective control of pulmonary vascular resistance with inhaled nitric oxide after cardiac operation. J Thorac Cardiovasc Surg 111:753–762–PubMed

75.

Solina AR, Ginsberg SH, Papp D, Pantin EJ, Denny J, Ghandivel I, Krause TJ (2002) Response to nitric oxide during adult cardiac surgery. J Invest Surg 15:5–14PubMed

76.

Stobierska-Dzierzek B, Awad H, Michler RE (2001) The evolving management of acute right-sided heart failure in cardiac transplant recipients. J Am Coll Cardiol 38:923–931PubMed

77.

Ardehali A, Hughes K, Sadeghi A, Esmailian F, Marelli D, Moriguchi J, Hamilton MA, Kobashigawa J, Laks H (2001) Inhaled nitric oxide for pulmonary hypertension after heart transplantation. Transplantation 72:638–641PubMed

78.

Mavroidis D, Sun BC, Pae WE Jr (1999) Bridge to transplantation: the Penn State experience. Ann Thorac Surg 68:684–67PubMed

79.

Oz MC, Argenziano M, Catanese KA, Gardocki MT, Goldstein DJ, Ashton RC, Gelijns AC, Rose EA, Levin HR (1997) Bridge experience with long-term implantable left ventricular assist devices. Are they an alternative to transplantation? Circulation 95:1844–1852PubMed

80.

Kavarana MN, Pessin-Minsley MS, Urtecho J, Catanese KA, Flannery M, Oz MC, Naka Y (2002) Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem. Ann Thorac Surg 73:745–750PubMed

81.

Macdonald PS, Keogh A, Mundy J, Rogers P, Nicholson A, Harrison G, Jansz P, Kaan AM, Spratt P (1998) Adjunctive use of inhaled nitric oxide during implantation of a left ventricular assist device. J Heart Lung Transplant 17:312–316PubMed

82.

Argenziano M, Choudhri AF, Moazami N, Rose EA, Smith CR, Levin HR, Smerling AJ, Oz MC (1998) Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension. Ann Thorac Surg 65:340–345PubMed

83.

Costard-Jackle A, Hill I, Schroeder JS, Fowler MB (1991) The influence of preoperative patient characteristics on early and late survival following cardiac transplantation. Circulation 84:III329–III337PubMed

84.

Kieler-Jensen N, Milocco I, Ricksten SE (1993) Pulmonary vasodilation after heart transplantation. A comparison among prostacyclin, sodium nitroprusside, and nitroglycerin on right ventricular function and pulmonary selectivity. J Heart Lung Transplant 12:179–184PubMed

85.

Rajek A, Pernerstorfer T, Kastner J, Mares P, Grabenwoger M, Sessler DI, Grubhofer G, Hiesmayr M (2000) Inhaled nitric oxide reduces pulmonary vascular resistance more than prostaglandin E(1) during heart transplantation. Anesth Analg 90:523–530

86.

Benumof JL (1985) One-lung ventilation and hypoxic pulmonary vasoconstriction: implications for anesthetic management. Anesth Analg 64:821–833PubMed

87.

Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM (1999) Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 104:1421–1429PubMed

88.

Rich GF, Lowson SM, Johns RA, Daugherty MO, Uncles DR (1994) Inhaled nitric oxide selectively decreases pulmonary vascular resistance without impairing oxygenation during one-lung ventilation in patients undergoing cardiac surgery. Anesthesiology 80:57–62PubMed

89.

Wilson WC, Kapelanski DP, Benumof JL, Newhart 2nd JW, Johnson FW, Channick RN (1997) Inhaled nitric oxide (40 ppm) during one-lung ventilation, in the lateral decubitus position, does not decrease pulmonary vascular resistance or improve oxygenation in normal patients. J Cardiothorac Vasc Anesth 11:172–176PubMed

90.

Sticher J, Scholz S, Boning O, Schermuly RT, Schumacher C, Walmrath D, Hempelmann G (2002) Small-dose nitric oxide improves oxygenation during one-lung ventilation: an experimental study. Anesth Analg 95:1557–1562

91.

Fradj K, Samain E, Delefosse D, Farah E, Marty J (1999) Placebo-controlled study of inhaled nitric oxide to treat hypoxaemia during one-lung ventilation. Br J Anaesth 82:208–212

92.

Rocca GD, Passariello M, Coccia C, Costa MG, Di Marco P, Venuta F, Rendina EA, Pietropaoli P (2001) Inhaled nitric oxide administration during one-lung ventilation in patients undergoing thoracic surgery. J Cardiothorac Vasc Anesth 15:218–223PubMed

93.

Wysocki M, Delclaux C, Roupie E, Langeron O, Liu N, Herman B, Lemaire F, Brochard L (1994) Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. Intensive Care Med 20:254–259PubMed

94.

Moutafis M, Liu N, Dalibon N, Kuhlman G, Ducros L, Castelain MH, Fischler M (1997) The effects of inhaled nitric oxide and its combination with intravenous almitrine on Pao2 during one-lung ventilation in patients undergoing thoracoscopic procedures. Anesth Analg 85:1130–1135

95.

Payen DM, Gatecel C, Plaisance P (1993) Almitrine effect on nitric oxide inhalation in adult respiratory distress syndrome. Lancet 341:1664

96.

Williams EA, Quinlan GJ, Goldstraw P, Gothard JW, Evans TW (1998) Postoperative lung injury and oxidative damage in patients undergoing pulmonary resection. Eur Respir J 11:1028–1034PubMed

97.

Chiche JD, Canivet JL, Damas P, Joris J, Lamy M (1995) Inhaled nitric oxide for hemodynamic support after postpneumonectomy ARDS. Intensive Care Med 21:675–678PubMed

98.

Rabkin DG, Sladen RN, DeMango A, Steinglass KM, Goldstein DJ (2001) Nitric oxide for the treatment of postpneumonectomy pulmonary edema. Ann Thorac Surg 72:272–274PubMed

99.

Waldow T, Alexiou K, Witt W, Wagner FM, Kappert U, Knaut M, Matschke K (2004) Protection of lung tissue against ischemia/reperfusion injury by preconditioning with inhaled nitric oxide in an in situ pig model of normothermic pulmonary ischemia. Nitric Oxide 10:195–201PubMed

100.

Thabut G, Brugiere O, Leseche G, Stern JB, Fradj K, Herve P, Jebrak G, Marty J, Fournier M, Mal H (2001) Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia/reperfusion injury after lung transplantation. Transplantation 71:1295–1300PubMed

101.

Meade MO, Granton JT, Matte-Martyn A, McRae K, Weaver B, Cripps P, Keshavjee SH (2003) A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med 167:1483–1489PubMed

102.

Myles PS, Venema HR (1995) Avoidance of cardiopulmonary bypass during bilateral sequential lung transplantation using inhaled nitric oxide. J Cardiothorac Vasc Anesth 9:571–574PubMed

103.

McIntyre RC Jr, Moore FA, Moore EE, Piedalue F, Haenel JS, Fullerton DA (1995) Inhaled nitric oxide variably improves oxygenation and pulmonary hypertension in patients with acute respiratory distress syndrome. J Trauma 39:418–425PubMed

104.

Puybasset L, Rouby JJ, Mourgeon E, Cluzel P, Souhil Z, Law-Koune JD, Stewart T, Devilliers C, Lu Q, Roche S et al (1995) Factors influencing cardiopulmonary effects of inhaled nitric oxide in acute respiratory failure. Am J Respir Crit Care Med 152:318–328PubMed

105.

Papazian L, Bregeon F, Gaillat F, Thirion X, Gainnier M, Gregoire R, Saux P, Gouin F, Jammes Y, Auffray JP (1998) Respective and combined effects of prone position and inhaled nitric oxide in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 157:580–585PubMed

106.

Gerlach H, Keh D, Semmerow A, Busch T, Lewandowski K, Pappert DM, Rossaint R, Falke KJ (2003) Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study. Am J Respir Crit Care Med 167:1008–1015PubMed

107.

Sokol J, Jacobs SE, Bohn D (2000) Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults. Cochrane Database Syst Rev:CD002787

108.

Putensen C, Hormann C, Kleinsasser A, Putensen-Himmer G (1998) Cardiopulmonary effects of aerosolized prostaglandin E1 and nitric oxide inhalation in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 157:1743–1747PubMed

109.

Walmrath D, Schneider T, Schermuly R, Olschewski H, Grimminger F, Seeger W (1996) Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am J Respir Crit Care Med 153:991–996PubMed

Title: Inhaled nitric oxide therapy in adults: European expert recommendations
Authors: Peter Germann
Antonio Braschi
Giorgio Della Rocca
Anh Tuan Dinh-Xuan
Konrad Falke
Claes Frostell
Lars E. Gustafsson
Philippe Hervé
Philippe Jolliet
Udo Kaisers
Hector Litvan
Duncan J. Macrae
Marco Maggiorini
Nandor Marczin
Bernd Mueller
Didier Payen
Marco Ranucci
Dietmar Schranz
Rainer Zimmermann
Roman Ullrich
Publication date: 01-08-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 8/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2675-4

2024 ASCO Annual Meeting

Springer Medicine

Inhaled nitric oxide therapy in adults: European expert recommendations

Abstract

Background

Methods

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Conclusions

Please log in to get access to this content

Other articles of this Issue 8/2005

Effect of the Y-piece of the ventilation circuit on ventilation requirements in extremely low birth weight infants

Nosocomial viral ventilator-associated pneumonia in the intensive care unit: a prospective cohort study

A quantitative computed tomography assessment of brain weight, volume, and specific gravity in severe head trauma

Successful long-term program for controlling methicillin-resistant Staphylococcus aureus in intensive care units

Does the brain become heavier or lighter after trauma? The long story of brain water content and its direct or indirect measurement

Acute purulent pericarditis in pneumococcal meningitis