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01-03-2006 | Original

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study

Authors: Charles L. Sprung, Yasser Sakr, Jean-Louis Vincent, Jean-Roger Le Gall, Konrad Reinhart, V. Marco Ranieri, Herwig Gerlach, Jonathan Fielden, C. B. Groba, Didier Payen

Published in: Intensive Care Medicine | Issue 3/2006

Abstract

Objective

To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs

Design and setting

Cohort, multicentre, observational study of 198 ICUs in 24 European countries.

Patients and interventions

All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.

Results

During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.

Conclusions

Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.

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Title: An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study
Authors: Charles L. Sprung
Yasser Sakr
Jean-Louis Vincent
Jean-Roger Le Gall
Konrad Reinhart
V. Marco Ranieri
Herwig Gerlach
Jonathan Fielden
C. B. Groba
Didier Payen
Publication date: 01-03-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-0039-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study

Abstract

Objective

Design and setting

Patients and interventions

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients and interventions

Results

Conclusions

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