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Intensive Care Medicine

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01-02-2005 | Original

One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system

Authors: Kevin B. Laupland, David A. Zygun, Christopher J. Doig, Sean M. Bagshaw, Lawrence W. Svenson, Gordon H. Fick

Published in: Intensive Care Medicine | Issue 2/2005

Abstract

Objective

The long-term mortality outcome associated with sepsis and septic shock has not been well defined in a nonselected critically ill population. This study investigated the occurrence and the role of bloodstream infection (BSI) associated sepsis and septic shock at time of intensive care unit (ICU) admission on the 1-year mortality of patients admitted to a regional critical care system.

Design and setting

Population-based inception cohort in all adult multidisciplinary and cardiovascular ICUs in the Calgary Health Region (population approx. 1 million) between 1 July 1999 and 31 March 2002.

Patients and participants

Adults (≥18 years; n=4,845) who had at least one ICU admission to CHR ICUs.

Results

In 251 (5%) patients there was BSI-associated sepsis at presentation to ICU, and 159 of these also had septic shock. The 28-day, 90-day, and 1-year mortality rates overall were 18%, 21%, and 24%: 23%, 30%, and 36% for BSI-associated sepsis without shock, and 51%, 57%, and 61% with shock, respectively. Surgical diagnosis, BSI-associated sepsis, and increasing age were independently associated with late (28-day to 1-year) mortality whereas higher APACHE II and TISS scores were associated with reduced odds in logistic regression analysis.

Conclusions

BSI-associated sepsis and septic shock are associated with increased risk of mortality persisting after 28-days up to 1 year or more. Follow-up duration beyond 28 days better defines the burden of illness associated with these syndromes.

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Title: One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system
Authors: Kevin B. Laupland
David A. Zygun
Christopher J. Doig
Sean M. Bagshaw
Lawrence W. Svenson
Gordon H. Fick
Publication date: 01-02-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 2/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2544-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system

Abstract

Objective

Design and setting

Patients and participants

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients and participants

Results

Conclusions

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