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01-11-2004 | Seminal Study

Oxygen transport—the oxygen delivery controversy

Authors: Jean-Louis Vincent, Daniel De Backer

Published in: Intensive Care Medicine | Issue 11/2004

Excerpt

Most cellular activities require energy in the form of oxygen, primarily obtained from the degradation of adenosine triphosphate (ATP) and other high-energy compounds. Oxygen must be present in sufficient amounts in the mitochondria to maintain effective concentrations of ATP in the electron transport system. Cells have to perform a series of activities essential for survival, including membrane transport, growth, cellular repair and maintenance processes. In addition, cells often have facultative functions such as contractility, electrolyte or protein transport, motility and various biosynthetic activities. If oxygen availability is limited, cellular oxygen consumption may fall and become supply-dependent. Facultative functions are the first to be altered, leading to organ dysfunction. If the situation becomes more serious, obligatory functions can no longer be maintained and irreversible alterations may occur. …

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Title: Oxygen transport—the oxygen delivery controversy
Authors: Jean-Louis Vincent
Daniel De Backer
Publication date: 01-11-2004
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 11/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2384-4

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Oxygen transport—the oxygen delivery controversy

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