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Intensive Care Medicine

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01-07-2004 | Experimental

Crystalloid strong ion difference determines metabolic acid–base change during acute normovolaemic haemodilution

Authors: Thomas J. Morgan, Balasubramanian Venkatesh, Jonathan Hall

Published in: Intensive Care Medicine | Issue 7/2004

Abstract

Objective

To study the acid–base effects of crystalloid strong ion difference (SID) during haemodilution.

Design

Prospective in vivo study.

Setting

University laboratory.

Subjects

Anaesthetised, mechanically ventilated Sprague-Dawley rats.

Interventions

Rats were studied in seven groups of three. Each group underwent normovolaemic haemodilution with one of seven crystalloids, with SID values from 0 to 40 mEq/l. Six exchanges of 9 ml crystalloid for 3 ml blood were performed.

Measurements and main results

[Hb] fell from 142±17 to 44±10 g/l (p<0.0001). Final plasma [lactate] was 1.1±0.6 mmol/l. Final standard base excess values ranged from −8 to +7 mmol/l, and were directly correlated with crystalloid SID (R²=0.91). By linear regression, the SID of a crystalloid balanced to maintain standard base excess=0 mmol/l was 23.7 mEq/l. Dilutions 2–5 produced similar results.

Conclusions

There is a linear relationship between crystalloid SID and post-dilutional metabolic acid–base status. The SID of a crystalloid balanced for normovolaemic haemodilution is 24 mEq/l. These principles are applicable in designing fluids for volume resuscitation, acute normovolaemic haemodilution and cardio-pulmonary bypass.

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Title: Crystalloid strong ion difference determines metabolic acid–base change during acute normovolaemic haemodilution
Authors: Thomas J. Morgan
Balasubramanian Venkatesh
Jonathan Hall
Publication date: 01-07-2004
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 7/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2176-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Crystalloid strong ion difference determines metabolic acid–base change during acute normovolaemic haemodilution

Abstract

Objective

Design

Setting

Subjects

Interventions

Measurements and main results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Subjects

Interventions

Measurements and main results

Conclusions

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