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01-05-2003 | Editorial

Does immunonutrition in patients with sepsis do more harm than good?

Authors: Daren K. Heyland, Andrew Samis

Published in: Intensive Care Medicine | Issue 5/2003

Excerpt

Almost 2 years ago, we published a meta-analysis of immunonutrition that demonstrated that the overall treatment effect associated with these diets in critically ill patients was a risk ratio (RR) of 1.18 (95% confidence intervals, 0.88, 1.58) [1]. While there was a clear and convincing signal that immunonutrition was beneficial to patients undergoing elective surgery, there was a suggestion that some sub-populations of critically ill patients were being harmed by the intervention, whereas others experienced a beneficial or neutral effect. Upon further examination of individual studies, important clues as to which population was harmed by the intervention became evident. …

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Dent DL, Heyland DK, Levy H, Martindale R, Tayek J, Schloerb P, Kelley MJ (2003) Immunonutrition may increase mortality in critically ill patients with pneumonia: results of a randomized trial. Crit Care Med 30:A17CrossRef

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Basttistella FD, Widergren JT, Anderson JT, et al (1997) A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma 43:52–58CrossRef

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Title: Does immunonutrition in patients with sepsis do more harm than good?
Authors: Daren K. Heyland
Andrew Samis
Publication date: 01-05-2003
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 5/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-1710-6

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Does immunonutrition in patients with sepsis do more harm than good?

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