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Social Psychiatry and Psychiatric Epidemiology

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Open Access 01-10-2014 | Commentary

The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research

Author: James B. Kirkbride

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 10/2014

Abstract

In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.

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Title: The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research
Author: James B. Kirkbride
Publication date: 01-10-2014
Publisher: Springer Berlin Heidelberg
Published in: Social Psychiatry and Psychiatric Epidemiology / Issue 10/2014
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-014-0961-6

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The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research

Abstract

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