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Diabetologia
Published in: Diabetologia 7/2017

Open Access 01-07-2017 | Review

Diabetes, bone and glucose-lowering agents: basic biology

Author: Beata Lecka-Czernik

Published in: Diabetologia | Issue 7/2017

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Abstract

Skeletal fragility often accompanies diabetes and does not appear to correlate with low bone mass or trauma severity in individuals with diabetes. Instead (and in contrast to those with osteoporotic bone disease), bone remodelling and bone turnover are compromised in both type 1 and type 2 diabetes, contributing to defective bone material quality. This review is one of a pair discussing the relationship between diabetes, bone and glucose-lowering agents; an accompanying review is provided in this issue of Diabetologia by Ann Schwartz (DOI: 10.​1007/​s00125-017-4283-6). This review presents basic science evidence that, alongside other organs, bone is affected in diabetes via impairments in glucose metabolism, toxic effects of glucose oxidative derivatives (advance glycation end-products [AGEs]), and via impairments in bone microvascular function and muscle endocrine function. The cellular and molecular basis for the effects of diabetes on bone are discussed, as is the impact of diabetes on the stem cell niche and fracture healing. Furthermore, the safety of clinically approved glucose-lowering therapies and the possibility of developing a single therapy that would be beneficial for both insulin sensitisation and diabetes bone syndrome are outlined.
Appendix
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Metadata
Title
Diabetes, bone and glucose-lowering agents: basic biology
Author
Beata Lecka-Czernik
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 7/2017
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-017-4269-4

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