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Diabetologia
Published in: Diabetologia 8/2013

01-08-2013 | Letter

What do we learn from measurements of HOMA-IR?

Author: G. M. Reaven

Published in: Diabetologia | Issue 8/2013

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Excerpt

To the Editor: Milan Kundera, the great Czech writer, has suggested that all coincidences are meaningful. This view may help explain why the month of April provided us with two excellent research studies, published in the official journals of the EASD [1] and ADA [2], the results of which raise questions as to the biological significance of measurements of the homeostasis model assessment of insulin resistance (HOMA-IR) [3]. HOMA-IR has been widely used as an estimate of insulin sensitivity in cross-sectional, longitudinal and prospective studies, and I believe that the results reported in these manuscripts necessitate reconsideration of what information is provided by this measurement. …
Literature
1.
Goldfine AB, Conlin PR, Halperin F et al (2013) A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 56:714–723PubMedCrossRef
2.
Pisprasert V, Ingram KH, Lopez-Davila MF, Munoz AJ, Garvey WT (2013) Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity: impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans. Diabetes Care 36:845–853PubMedCrossRef
3.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419PubMedCrossRef
4.
Katz A, Nambi SS, Mather K et al (2000) Quantitative Insulin Sensitivity Check Index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402–2410PubMedCrossRef
5.
Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462–1470PubMedCrossRef
6.
Stumvoll M, Mitrakou A, Pimenta W et al (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23:295–301PubMedCrossRef
Metadata
Title
What do we learn from measurements of HOMA-IR?
Author
G. M. Reaven
Publication date
01-08-2013
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 8/2013
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-013-2948-3

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