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Diabetologia
Published in: Diabetologia 1/2010

01-01-2010 | Letter

Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues. Reply to Nagel JM, Mansmann U, Wegscheider K et al. [letter] and Simon D [letter]

Authors: U. Grouven, L. G. Hemkens, R. Bender, P. T. Sawicki

Published in: Diabetologia | Issue 1/2010

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Excerpt

To the Editor: Nagel et al. [1] raise a number of questions regarding the analyses in our paper [2]; these analyses, in their opinion, led to confounded measures of association. We agree that potential confounding plays an essential role and can never be completely ruled out in analyses of observational data. However, we do not agree that the possibility of confounding inevitably leads to the conclusion that such results are definitely wrong and cannot reflect real risks. …
Literature
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Hemkens LG, Grouven U, Bender R et al (2009) Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia 52:1732–1744CrossRefPubMed
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Thefeld W (1999) Prevalence of diabetes mellitus among adults in Germany. Gesundheitswesen 61:S85–S89 (article in German)PubMed
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Andersen PK, Abidstrom SZ, Rosthøj S (2002) Competing risks as a multi-state model. Stat Methods Med Res 11:203–215CrossRefPubMed
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Gooley TA, Leisenring W, Crowley J, Storer BE (1999) Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 18:695–706CrossRefPubMed
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Pocock SJ, Smeeth L (2009) Insulin glargine and malignancy: an unwarranted alarm. Lancet 374:511–513CrossRefPubMed
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Hemkens LG, Grouven U, Bender R, Sawicki PT. Response to Pocock SJ, Smeeth L. Insulin glargine and malignancy: an unwarranted alarm. Lancet 2009 (in press).
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Kurtzhals P, Schäffer L, Sørensen A et al (2000) Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 49:999–1005CrossRefPubMed
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Bundesärztekammer (Arbeitsgemeinschaft der Deutschen Ärztekammern), Arzneimittelkommission der deutschen Ärzteschaft, Deutsche Diabetes Gesellschaft, Fachkommission Diabetes Sachsen, Deutsche Gesellschaft für Innere Medizin, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (eds) Nationale Versorgungsleitlinie Typ 2 Diabetes mellitus (Stand April 2003) Kurzfassung. National Guideline Type 2 Diabetes Mellitus (April 2003) Short Version. Available from www.​versorgungsleitl​inien.​de/​themen/​pdf/​nvldiabetes.​pdf, accessed 29 September 2009 (article in German)
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Metadata
Title
Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues. Reply to Nagel JM, Mansmann U, Wegscheider K et al. [letter] and Simon D [letter]
Authors
U. Grouven
L. G. Hemkens
R. Bender
P. T. Sawicki
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 1/2010
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-009-1582-6

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