Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Diabetologia
Published in: Diabetologia 5/2009

01-05-2009 | For Debate

Glucose allostasis: Emperor’s new clothes?

Authors: T. J. Wilkin, B. S. Metcalf

Published in: Diabetologia | Issue 5/2009

Login to get access

Excerpt

Homeostasis denotes the tendency of a system to defend itself against perturbation. The system employed—the negative feedback loop—is ubiquitous, in nature and in mankind’s emulation of it. The term homeostasis literally means ‘maintenance of the same’ and implies minimal change in response to load. Recently, the term allostasis has been used in the context of glucose control to distinguish a state of stability, despite impaired control [1]. It has been given a name, an identity and a place in the literature [1‐3], but does it have a theoretical basis? …
Literature
1.
Stumvoll M, Tataranni PA, Stefan N, Vozarova B, Bogardus C (2003) Glucose allostasis. Diabetes 52:903–909PubMedCrossRef
2.
Stumvoll M, Tataranni PA, Bogardus C (2005) The hyperbolic law—a 25-year perspective. Diabetologia 48:207–209PubMedCrossRef
3.
Stumvoll M, Tataranni PA, Bogardus C (2004) The role of glucose allostasis in type 2 diabetes. Rev Endocr Metab Disord 5:99–103PubMedCrossRef
4.
Wilkin TJ (1998) Endocrine feedback control in health and disease. In: Bittar EE, Bittar N (eds) The principles of medical biology. JAI Press, Greenwich, pp 1–28
5.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419PubMedCrossRef
6.
Levy JC, Matthews DR, Hermans MP (1998) Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21:2191–2192PubMedCrossRef
7.
Sterling P, Eyer J (1988) Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J (eds) Handbook of life stress, cognition and health. Wiley, New York, pp 629–649
8.
Wilkin TJ, Storey BE, Isles TE, Crooks J, Beck JS (1977) High TSH concentrations in “euthyroidism”: explanation based on control-loop theory. Br Med J 1:993–996PubMedCrossRef
Metadata
Title
Glucose allostasis: Emperor’s new clothes?
Authors
T. J. Wilkin
B. S. Metcalf
Publication date
01-05-2009
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 5/2009
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-009-1295-x

Other articles of this Issue 5/2009

Diabetologia 5/2009 Go to the issue

Review

Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice

For Debate

Glucose allostasis: Disrobing common wisdom

Article

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

Review

The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

Article

Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes

Letter

GlaxoSmithKline responds to the consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits