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Published in: European Journal of Trauma and Emergency Surgery 6/2013

01-12-2013 | Review Article

Deep venous thrombosis following different isolated lower extremity fractures: what is known about prevalences, locations, risk factors and prophylaxis?

Authors: S. Decker, M. J. Weaver

Published in: European Journal of Trauma and Emergency Surgery | Issue 6/2013

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Abstract

Introduction

Deep venous thrombosis (DVT) offers a high risk of morbidity and mortality, especially in case of pulmonary embolism. Precise data as to DVT after isolated lower extremity fractures (ILEFs) are rare. Even organizations like the American Academy of Orthopaedic Surgeons or the American College of Chest Physicians do not state exact recommendations as to optimal DVT prophylaxis (ppx) after ILEFs.

Prevalence

The incidence of DVT ranges from 5 to 86 % depending on the fracture whereas femur fractures offer the highest risk for clotting. The incidence seems to decrease in more distal fractures. Location: The risk to develop proximal clots is likely low, however, especially these are feared by surgeons. DVT can occur in both the injured and uninjured leg with a trend for higher incidences in the injured leg.

Risk factors

Risk factors for DVT after ILEF seem to be similar to risk factors for DVT development after orthopaedic surgery and in general. Risk factors caused by surgeons are the use of a tourniquet, prolonged operative time and a delay from injury to surgery.

Prophylaxis

Low molecular weight heparin is favoured by many authors, however, warfarin and acetylsalicylic acid are also used. Clear recommendations are still missing.

Conclusion

The rate of morbidity caused by DVT after ILEF is poorly understood so far. Exact data on prevalences are missing and optimal DVT prophylaxis still has to be defined.
Literature
1.
go back to reference Ciccone WJ 2nd, Fox PS, Neumyer M, Rubens D, Parrish WM, Pellegrini VD Jr. Ultrasound surveillance for asymptomatic deep venous thrombosis after total joint replacement. J Bone Joint Surg Am. 1998;80(8):1167–74.PubMed Ciccone WJ 2nd, Fox PS, Neumyer M, Rubens D, Parrish WM, Pellegrini VD Jr. Ultrasound surveillance for asymptomatic deep venous thrombosis after total joint replacement. J Bone Joint Surg Am. 1998;80(8):1167–74.PubMed
2.
go back to reference Garino JP, Lotke PA, Kitziger KJ, Steinberg ME. Deep venous thrombosis after total joint arthroplasty. The role of compression ultrasonography and the importance of the experience of the technician. J Bone Joint Surg Am. 1996;78(9):1359–65.PubMed Garino JP, Lotke PA, Kitziger KJ, Steinberg ME. Deep venous thrombosis after total joint arthroplasty. The role of compression ultrasonography and the importance of the experience of the technician. J Bone Joint Surg Am. 1996;78(9):1359–65.PubMed
3.
go back to reference Lotke PA, Palevsky H, Keenan AM, Meranze S, Steinberg ME, Ecker ML, Kelley MA. Aspirin and warfarin for thromboembolic disease after total joint arthroplasty. Clin Orthop Relat Res. 1996;324:251–8.PubMedCrossRef Lotke PA, Palevsky H, Keenan AM, Meranze S, Steinberg ME, Ecker ML, Kelley MA. Aspirin and warfarin for thromboembolic disease after total joint arthroplasty. Clin Orthop Relat Res. 1996;324:251–8.PubMedCrossRef
4.
go back to reference Lotke PA, Steinberg ME, Ecker ML. Significance of deep venous thrombosis in the lower extremity after total joint arthroplasty. Clin Orthop Relat Res. 1994;299:25–30.PubMed Lotke PA, Steinberg ME, Ecker ML. Significance of deep venous thrombosis in the lower extremity after total joint arthroplasty. Clin Orthop Relat Res. 1994;299:25–30.PubMed
5.
go back to reference Nillius AS, Nylander G. Deep vein thrombosis after total hip replacement: a clinical and phlebographic study. Br J Surg. 1979;66(5):324–6.PubMedCrossRef Nillius AS, Nylander G. Deep vein thrombosis after total hip replacement: a clinical and phlebographic study. Br J Surg. 1979;66(5):324–6.PubMedCrossRef
6.
go back to reference Robinson KS, Anderson DR, Gross M, Petrie D, Leighton R, Stanish W, Alexander D, Mitchell M, Flemming B, Gent M. Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the post-arthroplasty screening study. A randomized, controlled trial. Ann Intern Med. 1997;127(6):439–45.PubMedCrossRef Robinson KS, Anderson DR, Gross M, Petrie D, Leighton R, Stanish W, Alexander D, Mitchell M, Flemming B, Gent M. Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the post-arthroplasty screening study. A randomized, controlled trial. Ann Intern Med. 1997;127(6):439–45.PubMedCrossRef
7.
go back to reference Robinson KS, Anderson DR, Gross M, Petrie D, Leighton R, Stanish W, Alexander D, Mitchell M, Mason W, Flemming B, Fairhurst-Vaughan M, Gent M. Accuracy of screening compression ultrasonography and clinical examination for the diagnosis of deep vein thrombosis after total hip or knee arthroplasty. Can J Surg. 1998;41(5):368–73.PubMed Robinson KS, Anderson DR, Gross M, Petrie D, Leighton R, Stanish W, Alexander D, Mitchell M, Mason W, Flemming B, Fairhurst-Vaughan M, Gent M. Accuracy of screening compression ultrasonography and clinical examination for the diagnosis of deep vein thrombosis after total hip or knee arthroplasty. Can J Surg. 1998;41(5):368–73.PubMed
8.
go back to reference Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;331(24):1601–6.PubMedCrossRef Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;331(24):1601–6.PubMedCrossRef
10.
go back to reference Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, Colwell CW; American College of Chest Physicians. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S–453S.PubMedCrossRef Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, Colwell CW; American College of Chest Physicians. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S–453S.PubMedCrossRef
11.
go back to reference National Institute for Health and Clinical Excellence (NICE). Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital. Clinical guidelines, CG92. London: NICE; 2010. http://guidance.nice.org.uk/CG92. National Institute for Health and Clinical Excellence (NICE). Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital. Clinical guidelines, CG92. London: NICE; 2010. http://​guidance.​nice.​org.​uk/​CG92.
12.
go back to reference Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):338S–400S.PubMedCrossRef Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):338S–400S.PubMedCrossRef
13.
go back to reference McKenna R, Bachmann F, Kaushal SP, Galante JO. Thromboembolic disease in patients undergoing total knee replacement. J Bone Joint Surg Am. 1976;58(7):928–32.PubMed McKenna R, Bachmann F, Kaushal SP, Galante JO. Thromboembolic disease in patients undergoing total knee replacement. J Bone Joint Surg Am. 1976;58(7):928–32.PubMed
14.
go back to reference Johnson R, Carmichael JH, Almond HG, Loynes RP. Deep venous thrombosis following Charnley arthroplasty. Clin Orthop Relat Res. 1978;132:24–30.PubMed Johnson R, Carmichael JH, Almond HG, Loynes RP. Deep venous thrombosis following Charnley arthroplasty. Clin Orthop Relat Res. 1978;132:24–30.PubMed
15.
go back to reference Guyer RD, Booth RE Jr, Rothman RH. The detection and prevention of pulmonary embolism in total hip replacement. A study comparing aspirin and low-dose warfarin. J Bone Joint Surg Am. 1982;64(7):1040–4.PubMed Guyer RD, Booth RE Jr, Rothman RH. The detection and prevention of pulmonary embolism in total hip replacement. A study comparing aspirin and low-dose warfarin. J Bone Joint Surg Am. 1982;64(7):1040–4.PubMed
16.
go back to reference Huo MH, Salvati EA, Sharrock NE, Brien WW, Sculco TP, Pellicci PM, Mineo R, Go G. Intraoperative heparin thromboembolic prophylaxis in primary total hip arthroplasty. A prospective, randomized, controlled, clinical trial. Clin Orthop Relat Res. 1992;274:35–46.PubMed Huo MH, Salvati EA, Sharrock NE, Brien WW, Sculco TP, Pellicci PM, Mineo R, Go G. Intraoperative heparin thromboembolic prophylaxis in primary total hip arthroplasty. A prospective, randomized, controlled, clinical trial. Clin Orthop Relat Res. 1992;274:35–46.PubMed
17.
go back to reference Paiement GD, Schutzer SF, Wessinger SJ, Harris WH. Influence of prophylaxis on proximal venous thrombus formation after total hip arthroplasty. J Arthroplasty. 1992;7(4):471–5.PubMedCrossRef Paiement GD, Schutzer SF, Wessinger SJ, Harris WH. Influence of prophylaxis on proximal venous thrombus formation after total hip arthroplasty. J Arthroplasty. 1992;7(4):471–5.PubMedCrossRef
18.
go back to reference Paiement G, Wessinger SJ, Waltman AC, Harris WH. Low-dose warfarin versus external pneumatic compression for prophylaxis against venous thromboembolism following total hip replacement. J Arthroplasty. 1987;2(1):23–6.PubMedCrossRef Paiement G, Wessinger SJ, Waltman AC, Harris WH. Low-dose warfarin versus external pneumatic compression for prophylaxis against venous thromboembolism following total hip replacement. J Arthroplasty. 1987;2(1):23–6.PubMedCrossRef
19.
go back to reference Pellegrini VD Jr, Langhans MJ, Totterman S, Marder VJ, Francis CW. Embolic complications of calf thrombosis following total hip arthroplasty. J Arthroplasty. 1993;8(5):449–57.PubMedCrossRef Pellegrini VD Jr, Langhans MJ, Totterman S, Marder VJ, Francis CW. Embolic complications of calf thrombosis following total hip arthroplasty. J Arthroplasty. 1993;8(5):449–57.PubMedCrossRef
20.
go back to reference Tørholm C, Broeng L, Jørgensen PS, Bjerregaard P, Josephsen L, Jørgensen PK, Hagen K, Knudsen JB. Thromboprophylaxis by low-molecular-weight heparin in elective hip surgery. A placebo controlled study. J Bone Joint Surg Br. 1991;73(3):434–8.PubMed Tørholm C, Broeng L, Jørgensen PS, Bjerregaard P, Josephsen L, Jørgensen PK, Hagen K, Knudsen JB. Thromboprophylaxis by low-molecular-weight heparin in elective hip surgery. A placebo controlled study. J Bone Joint Surg Br. 1991;73(3):434–8.PubMed
21.
go back to reference Turpie AG, Levine MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M, Hull RD, Gent M. A randomized controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery. N Engl J Med. 1986;315(15):925–9.PubMedCrossRef Turpie AG, Levine MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M, Hull RD, Gent M. A randomized controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery. N Engl J Med. 1986;315(15):925–9.PubMedCrossRef
22.
go back to reference Wells PS, Lensing AW, Davidson BL, Prins MH, Hirsh J. Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery. A meta-analysis. Ann Intern Med. 1995;122(1):47–53.PubMedCrossRef Wells PS, Lensing AW, Davidson BL, Prins MH, Hirsh J. Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery. A meta-analysis. Ann Intern Med. 1995;122(1):47–53.PubMedCrossRef
23.
go back to reference Galasko CS, Edwards DH, Fearn CB, Barber HM. The value of low dosage heparin for the prophylaxis of thromboembolism in patients with transcervical and intertrochanteric femoral fractures. Acta Orthop Scand. 1976;47(3):276–82.PubMedCrossRef Galasko CS, Edwards DH, Fearn CB, Barber HM. The value of low dosage heparin for the prophylaxis of thromboembolism in patients with transcervical and intertrochanteric femoral fractures. Acta Orthop Scand. 1976;47(3):276–82.PubMedCrossRef
24.
go back to reference Montrey JS, Kistner RL, Kong AY, Lindberg RF, Mayfield GW, Jones DA, Mitsunaga MM. Thromboembolism following hip fracture. J Trauma. 1985;25(6):534–7.PubMedCrossRef Montrey JS, Kistner RL, Kong AY, Lindberg RF, Mayfield GW, Jones DA, Mitsunaga MM. Thromboembolism following hip fracture. J Trauma. 1985;25(6):534–7.PubMedCrossRef
25.
go back to reference Morris GK, Mitchell JR. Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen. Br Med J. 1977;1(6060):535–7.PubMedCrossRef Morris GK, Mitchell JR. Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen. Br Med J. 1977;1(6060):535–7.PubMedCrossRef
26.
go back to reference Sevitt S, Gallagher NG. Prevention of venous thrombosis and pulmonary embolism in injured patients. A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur. Lancet. 1959;2(7110):981–9.PubMedCrossRef Sevitt S, Gallagher NG. Prevention of venous thrombosis and pulmonary embolism in injured patients. A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur. Lancet. 1959;2(7110):981–9.PubMedCrossRef
27.
go back to reference Smyrnis SA, Kolios AS, Agnantis JK. Deep-vein thrombosis in patients with fracture of the upper part of the femur. A phlebographic study. Br J Surg. 1973;60(6):447–50.PubMedCrossRef Smyrnis SA, Kolios AS, Agnantis JK. Deep-vein thrombosis in patients with fracture of the upper part of the femur. A phlebographic study. Br J Surg. 1973;60(6):447–50.PubMedCrossRef
28.
go back to reference Abelseth G, Buckley RE, Pineo GE, Hull R, Rose MS. Incidence of deep-vein thrombosis in patients with fractures of the lower extremity distal to the hip. J Orthop Trauma. 1996;10(4):230–5.PubMedCrossRef Abelseth G, Buckley RE, Pineo GE, Hull R, Rose MS. Incidence of deep-vein thrombosis in patients with fractures of the lower extremity distal to the hip. J Orthop Trauma. 1996;10(4):230–5.PubMedCrossRef
29.
go back to reference Kudsk KA, Fabian TC, Baum S, Gold RE, Mangiante E, Voeller G. Silent deep vein thrombosis in immobilized multiple trauma patients. Am J Surg. 1989;158(6):515–9.PubMedCrossRef Kudsk KA, Fabian TC, Baum S, Gold RE, Mangiante E, Voeller G. Silent deep vein thrombosis in immobilized multiple trauma patients. Am J Surg. 1989;158(6):515–9.PubMedCrossRef
30.
go back to reference Haake DA, Berkman SA. Venous thromboembolic disease after hip surgery. Risk factors, prophylaxis, and diagnosis. Clin Orthop Relat Res. 1989;242:212–31.PubMed Haake DA, Berkman SA. Venous thromboembolic disease after hip surgery. Risk factors, prophylaxis, and diagnosis. Clin Orthop Relat Res. 1989;242:212–31.PubMed
31.
go back to reference Sevitt S, Gallagher N. Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients. Br J Surg. 1961;48:475–89.PubMedCrossRef Sevitt S, Gallagher N. Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients. Br J Surg. 1961;48:475–89.PubMedCrossRef
32.
go back to reference Douketis JD, Kearon C, Bates S, Duku EK, Ginsberg JS. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. JAMA. 1998;279(6):458–62.PubMedCrossRef Douketis JD, Kearon C, Bates S, Duku EK, Ginsberg JS. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. JAMA. 1998;279(6):458–62.PubMedCrossRef
33.
go back to reference Bagot CN, Arya R. Virchow and his triad: a question of attribution. Br J Haematol. 2008;143(2):180–90.CrossRef Bagot CN, Arya R. Virchow and his triad: a question of attribution. Br J Haematol. 2008;143(2):180–90.CrossRef
34.
go back to reference Storti S, Crucitti P, Cina G. Risk factors and prevention of venous thromboembolism. Rays. 1996;21(3):439–60.PubMed Storti S, Crucitti P, Cina G. Risk factors and prevention of venous thromboembolism. Rays. 1996;21(3):439–60.PubMed
35.
go back to reference Allaart CF, Poort SR, Rosendaal FR, Reitsma PH, Bertina RM, Briët E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet. 1993;341(8838):134–8.PubMedCrossRef Allaart CF, Poort SR, Rosendaal FR, Reitsma PH, Bertina RM, Briët E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet. 1993;341(8838):134–8.PubMedCrossRef
36.
go back to reference Malm J, Laurell M, Nilsson IM, Dahlbäck B. Thromboembolic disease—critical evaluation of laboratory investigation. Thromb Haemost. 1992;68(1):7–13.PubMed Malm J, Laurell M, Nilsson IM, Dahlbäck B. Thromboembolic disease—critical evaluation of laboratory investigation. Thromb Haemost. 1992;68(1):7–13.PubMed
37.
go back to reference Heijboer H, Brandjes DP, Büller HR, Sturk A, ten Cate JW. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med. 1990;323(22):1512–6.PubMedCrossRef Heijboer H, Brandjes DP, Büller HR, Sturk A, ten Cate JW. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med. 1990;323(22):1512–6.PubMedCrossRef
38.
go back to reference Tabernero MD, Tomas JF, Alberca I, Orfao A, Lopez Borrasca A, Vicente V. Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis. Am J Hematol. 1991;36(4):249–54.PubMedCrossRef Tabernero MD, Tomas JF, Alberca I, Orfao A, Lopez Borrasca A, Vicente V. Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis. Am J Hematol. 1991;36(4):249–54.PubMedCrossRef
39.
go back to reference Coon WW. Venous thromboembolism. Prevalence, risk factors, and prevention. Clin Chest Med. 1984;5(3):391–401.PubMed Coon WW. Venous thromboembolism. Prevalence, risk factors, and prevention. Clin Chest Med. 1984;5(3):391–401.PubMed
40.
go back to reference Knudson MM, Ikossi DG, Khaw L, Morabito D, Speetzen LS. Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg. 2004;240(3):490–6; discussion 496–8.PubMedCrossRef Knudson MM, Ikossi DG, Khaw L, Morabito D, Speetzen LS. Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg. 2004;240(3):490–6; discussion 496–8.PubMedCrossRef
41.
go back to reference Norris CS, Greenfield LJ, Herrmann JB. Free-floating iliofemoral thrombus. A risk of pulmonary embolism. Arch Surg. 1985;120(7):806–8.PubMedCrossRef Norris CS, Greenfield LJ, Herrmann JB. Free-floating iliofemoral thrombus. A risk of pulmonary embolism. Arch Surg. 1985;120(7):806–8.PubMedCrossRef
42.
go back to reference Radomski JS, Jarrell BE, Carabasi RA, Yang SL, Koolpe H. Risk of pulmonary embolus with inferior vena cava thrombosis. Am Surg. 1987;53(2):97–101.PubMed Radomski JS, Jarrell BE, Carabasi RA, Yang SL, Koolpe H. Risk of pulmonary embolus with inferior vena cava thrombosis. Am Surg. 1987;53(2):97–101.PubMed
43.
go back to reference Hull RD, Hirsh J, Carter CJ, Jay RM, Dodd PE, Ockelford PA, Coates G, Gill GJ, Turpie AG, Doyle DJ, Buller HR, Raskob GE. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med. 1983;98(6):891–9.PubMedCrossRef Hull RD, Hirsh J, Carter CJ, Jay RM, Dodd PE, Ockelford PA, Coates G, Gill GJ, Turpie AG, Doyle DJ, Buller HR, Raskob GE. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med. 1983;98(6):891–9.PubMedCrossRef
44.
go back to reference Girard P, Musset D, Parent F, Maitre S, Phlippoteau C, Simonneau G. High prevalence of detectable deep venous thrombosis in patients with acute pulmonary embolism. Chest. 1999;116(4):903–8.PubMedCrossRef Girard P, Musset D, Parent F, Maitre S, Phlippoteau C, Simonneau G. High prevalence of detectable deep venous thrombosis in patients with acute pulmonary embolism. Chest. 1999;116(4):903–8.PubMedCrossRef
45.
go back to reference Kearon C. Natural history of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I22–30.PubMed Kearon C. Natural history of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I22–30.PubMed
46.
go back to reference Labropoulos N, Jen J, Jen H, Gasparis AP, Tassiopoulos AK. Recurrent deep vein thrombosis: long-term incidence and natural history. Ann Surg. 2010;251(4):749–53.PubMedCrossRef Labropoulos N, Jen J, Jen H, Gasparis AP, Tassiopoulos AK. Recurrent deep vein thrombosis: long-term incidence and natural history. Ann Surg. 2010;251(4):749–53.PubMedCrossRef
47.
go back to reference Douketis JD, Gu CS, Schulman S, Ghirarduzzi A, Pengo V, Prandoni P. The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism. Ann Intern Med. 2007;147(11):766–74.PubMedCrossRef Douketis JD, Gu CS, Schulman S, Ghirarduzzi A, Pengo V, Prandoni P. The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism. Ann Intern Med. 2007;147(11):766–74.PubMedCrossRef
48.
49.
go back to reference Sheiman RG, Weintraub JL, McArdle CR. Bilateral lower extremity US in the patient with bilateral symptoms of deep venous thrombosis: assessment of need. Radiology. 1995;196(2):379–81.PubMed Sheiman RG, Weintraub JL, McArdle CR. Bilateral lower extremity US in the patient with bilateral symptoms of deep venous thrombosis: assessment of need. Radiology. 1995;196(2):379–81.PubMed
50.
go back to reference Lapidus L, de Bri E, Ponzer S, Elvin A, Norén A, Rosfors S. High sensitivity with color duplex sonography in thrombosis screening after ankle fracture surgery. J Thromb Haemost. 2006;4(4):807–12.PubMedCrossRef Lapidus L, de Bri E, Ponzer S, Elvin A, Norén A, Rosfors S. High sensitivity with color duplex sonography in thrombosis screening after ankle fracture surgery. J Thromb Haemost. 2006;4(4):807–12.PubMedCrossRef
51.
go back to reference Cogo A, Lensing AW, Wells P, Prandoni P, Büller HR. Noninvasive objective tests for the diagnosis of clinically suspected deep-vein thrombosis. Haemostasis. 1995;25(1–2):27–39.PubMed Cogo A, Lensing AW, Wells P, Prandoni P, Büller HR. Noninvasive objective tests for the diagnosis of clinically suspected deep-vein thrombosis. Haemostasis. 1995;25(1–2):27–39.PubMed
52.
go back to reference Rose SC, Zwiebel WJ, Nelson BD, Priest DL, Knighton RA, Brown JW, Lawrence PF, Stults BM, Reading JC, Miller FJ. Symptomatic lower extremity deep venous thrombosis: accuracy, limitations, and role of color duplex flow imaging in diagnosis. Radiology. 1990;175(3):639–44.PubMed Rose SC, Zwiebel WJ, Nelson BD, Priest DL, Knighton RA, Brown JW, Lawrence PF, Stults BM, Reading JC, Miller FJ. Symptomatic lower extremity deep venous thrombosis: accuracy, limitations, and role of color duplex flow imaging in diagnosis. Radiology. 1990;175(3):639–44.PubMed
53.
go back to reference Atri M, Herba MJ, Reinhold C, Leclerc J, Ye S, Illescas FF, Bret PM. Accuracy of sonography in the evaluation of calf deep vein thrombosis in both postoperative surveillance and symptomatic patients. AJR Am J Roentgenol. 1996;166(6):1361–7.PubMedCrossRef Atri M, Herba MJ, Reinhold C, Leclerc J, Ye S, Illescas FF, Bret PM. Accuracy of sonography in the evaluation of calf deep vein thrombosis in both postoperative surveillance and symptomatic patients. AJR Am J Roentgenol. 1996;166(6):1361–7.PubMedCrossRef
54.
go back to reference Simons GR, Skibo LK, Polak JF, Creager MA, Klapec-Fay JM, Goldhaber SZ. Utility of leg ultrasonography in suspected symptomatic isolated calf deep venous thrombosis. Am J Med. 1995;99(1):43–7.PubMedCrossRef Simons GR, Skibo LK, Polak JF, Creager MA, Klapec-Fay JM, Goldhaber SZ. Utility of leg ultrasonography in suspected symptomatic isolated calf deep venous thrombosis. Am J Med. 1995;99(1):43–7.PubMedCrossRef
55.
go back to reference Yucel EK, Fisher JS, Egglin TK, Geller SC, Waltman AC. Isolated calf venous thrombosis: diagnosis with compression US. Radiology. 1991;179(2):443–6.PubMed Yucel EK, Fisher JS, Egglin TK, Geller SC, Waltman AC. Isolated calf venous thrombosis: diagnosis with compression US. Radiology. 1991;179(2):443–6.PubMed
56.
go back to reference Bongard O, Wicky J, Peter R, Simonovska S, Vogel JJ, de Moerloose P, Reber G, Bonameaux H. D-dimer plasma measurement in patients undergoing major hip surgery: use in the prediction and diagnosis of postoperative proximal vein thrombosis. Thromb Res. 1994;74(5):487–93.PubMedCrossRef Bongard O, Wicky J, Peter R, Simonovska S, Vogel JJ, de Moerloose P, Reber G, Bonameaux H. D-dimer plasma measurement in patients undergoing major hip surgery: use in the prediction and diagnosis of postoperative proximal vein thrombosis. Thromb Res. 1994;74(5):487–93.PubMedCrossRef
57.
go back to reference Ginsberg JS, Brill-Edwards P, Panju A, Patel A, McGinnis J, Smith F, Dale I, Johnston M, Ofosu F. Pre-operative plasma levels of thrombin-antithrombin III complexes correlate with the development of venous thrombosis after major hip or knee surgery. Thromb Haemost. 1995;74(2):602–5.PubMed Ginsberg JS, Brill-Edwards P, Panju A, Patel A, McGinnis J, Smith F, Dale I, Johnston M, Ofosu F. Pre-operative plasma levels of thrombin-antithrombin III complexes correlate with the development of venous thrombosis after major hip or knee surgery. Thromb Haemost. 1995;74(2):602–5.PubMed
58.
go back to reference Cofrancesco E, Cortellaro M, Corradi A, Ravasi F, Bertocchi F. Coagulation activation markers in the prediction of venous thrombosis after elective hip surgery. Thromb Haemost. 1997;77(2):267–9.PubMed Cofrancesco E, Cortellaro M, Corradi A, Ravasi F, Bertocchi F. Coagulation activation markers in the prediction of venous thrombosis after elective hip surgery. Thromb Haemost. 1997;77(2):267–9.PubMed
59.
go back to reference Cofrancesco E, Cortellaro M, Corradi A, Ravasi F, Bertocchi F. Clinical utility of prothrombin fragment 1+2, thrombin antithrombin III complexes and D-dimer measurements in the diagnosis of deep vein thrombosis following total hip replacement. Thromb Haemost. 1998;79(3):509–10.PubMed Cofrancesco E, Cortellaro M, Corradi A, Ravasi F, Bertocchi F. Clinical utility of prothrombin fragment 1+2, thrombin antithrombin III complexes and D-dimer measurements in the diagnosis of deep vein thrombosis following total hip replacement. Thromb Haemost. 1998;79(3):509–10.PubMed
60.
go back to reference Dunn ID, Hui AC, Triffitt PD, Crozier AE, Gregg PJ, Sinclair ME, Armstrong AL, Mitchell VE. Plasma D-dimer as a marker for postoperative deep venous thrombosis. A study after total hip or knee arthroplasty. Thromb Haemost. 1994;72(5):663–5.PubMed Dunn ID, Hui AC, Triffitt PD, Crozier AE, Gregg PJ, Sinclair ME, Armstrong AL, Mitchell VE. Plasma D-dimer as a marker for postoperative deep venous thrombosis. A study after total hip or knee arthroplasty. Thromb Haemost. 1994;72(5):663–5.PubMed
61.
go back to reference Crippa L, Ravasi F, D’Angelo SV, Varagona R, Milani E, Safa O, Tessari L, D’Angelo A. Diagnostic value of compression ultrasonography and fibrinogen-related parameters for the detection of postoperative deep vein thrombosis following elective hip replacement: a pilot study. Thromb Haemost. 1995;74(5):1235–9.PubMed Crippa L, Ravasi F, D’Angelo SV, Varagona R, Milani E, Safa O, Tessari L, D’Angelo A. Diagnostic value of compression ultrasonography and fibrinogen-related parameters for the detection of postoperative deep vein thrombosis following elective hip replacement: a pilot study. Thromb Haemost. 1995;74(5):1235–9.PubMed
62.
go back to reference Douketis JD, McGinnis J, Ginsberg JS. The clinical utility of a rapid bedside D-dimer assay for screening of deep vein thrombosis following orthopaedic surgery. Thromb Haemost. 1997;78(4):1300–1.PubMed Douketis JD, McGinnis J, Ginsberg JS. The clinical utility of a rapid bedside D-dimer assay for screening of deep vein thrombosis following orthopaedic surgery. Thromb Haemost. 1997;78(4):1300–1.PubMed
63.
go back to reference Haentjens P. Thromboembolic prophylaxis in orthopaedic trauma patients: a comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin (nadroparin calcium). Injury. 1996;27(6):385–90.PubMedCrossRef Haentjens P. Thromboembolic prophylaxis in orthopaedic trauma patients: a comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin (nadroparin calcium). Injury. 1996;27(6):385–90.PubMedCrossRef
64.
go back to reference Wenzl ME, Hasse W, Seide K, Wolter D. Prevention of thromboembolism with low-molecular-weight heparin in orthopedic surgery: a 5-year experience. Clin Appl Thromb Hemost. 2004;10(1):1–4.PubMedCrossRef Wenzl ME, Hasse W, Seide K, Wolter D. Prevention of thromboembolism with low-molecular-weight heparin in orthopedic surgery: a 5-year experience. Clin Appl Thromb Hemost. 2004;10(1):1–4.PubMedCrossRef
65.
go back to reference Hjelmstedt A, Bergvall U. Phlebographic study of the incidence of thrombosis in the injured and uninjured limb in 55 cases of tibial fracture. Acta Chir Scand. 1968;134(3):229–34.PubMed Hjelmstedt A, Bergvall U. Phlebographic study of the incidence of thrombosis in the injured and uninjured limb in 55 cases of tibial fracture. Acta Chir Scand. 1968;134(3):229–34.PubMed
66.
go back to reference Goel DP, Buckley R, deVries G, Abelseth G, Ni A, Gray R. Prophylaxis of deep-vein thrombosis in fractures below the knee: a prospective randomised controlled trial. J Bone Joint Surg Br. 2009;91(3):388–94.PubMed Goel DP, Buckley R, deVries G, Abelseth G, Ni A, Gray R. Prophylaxis of deep-vein thrombosis in fractures below the knee: a prospective randomised controlled trial. J Bone Joint Surg Br. 2009;91(3):388–94.PubMed
67.
go back to reference Maffulli N, Testa V, Capasso G. Use of a tourniquet in the internal fixation of fractures of the distal part of the fibula. A prospective, randomized trial. J Bone Joint Surg Am. 1993;75(5):700–3.PubMed Maffulli N, Testa V, Capasso G. Use of a tourniquet in the internal fixation of fractures of the distal part of the fibula. A prospective, randomized trial. J Bone Joint Surg Am. 1993;75(5):700–3.PubMed
68.
go back to reference Wang F, Wera G, Knoblich GO, Chou LB. Pulmonary embolism following operative treatment of ankle fractures: a report of three cases and review of the literature. Foot Ankle Int. 2002;23(5):406–10.PubMed Wang F, Wera G, Knoblich GO, Chou LB. Pulmonary embolism following operative treatment of ankle fractures: a report of three cases and review of the literature. Foot Ankle Int. 2002;23(5):406–10.PubMed
69.
go back to reference Patil S, Gandhi J, Curzon I, Hui AC. Incidence of deep-vein thrombosis in patients with fractures of the ankle treated in a plaster cast. J Bone Joint Surg Br. 2007;89(10):1340–3.PubMed Patil S, Gandhi J, Curzon I, Hui AC. Incidence of deep-vein thrombosis in patients with fractures of the ankle treated in a plaster cast. J Bone Joint Surg Br. 2007;89(10):1340–3.PubMed
70.
go back to reference Lapidus LJ, Ponzer S, Elvin A, Levander C, Lärfars G, Rosfors S, de Bri E. Prolonged thromboprophylaxis with dalteparin during immobilization after ankle fracture surgery: a randomized placebo-controlled, double-blind study. Acta Orthop. 2007;78(4):528–35.PubMedCrossRef Lapidus LJ, Ponzer S, Elvin A, Levander C, Lärfars G, Rosfors S, de Bri E. Prolonged thromboprophylaxis with dalteparin during immobilization after ankle fracture surgery: a randomized placebo-controlled, double-blind study. Acta Orthop. 2007;78(4):528–35.PubMedCrossRef
71.
go back to reference Weiss ES, Hayanga AJ, Efron DT, Noll K, Cornwell EE 3rd, Haut ER. Laterality of deep venous thrombosis among trauma patients: are we screening our patients adequately? J Surg Res. 2007;141(1):68–71.PubMedCrossRef Weiss ES, Hayanga AJ, Efron DT, Noll K, Cornwell EE 3rd, Haut ER. Laterality of deep venous thrombosis among trauma patients: are we screening our patients adequately? J Surg Res. 2007;141(1):68–71.PubMedCrossRef
72.
go back to reference Kujath P, Spannagel U, Habscheid W. Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb. Haemostasis. 1993;23(Suppl 1):20–6.PubMed Kujath P, Spannagel U, Habscheid W. Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb. Haemostasis. 1993;23(Suppl 1):20–6.PubMed
73.
go back to reference Spannagel U, Kujath P. Low molecular weight heparin for the prevention of thromboembolism in outpatients immobilized by plaster cast. Semin Thromb Hemost. 1993;19(Suppl 1):131–41.PubMed Spannagel U, Kujath P. Low molecular weight heparin for the prevention of thromboembolism in outpatients immobilized by plaster cast. Semin Thromb Hemost. 1993;19(Suppl 1):131–41.PubMed
74.
go back to reference Batra S, Kurup H, Gul A, Andrew JG. Thromboprophylaxis following cast immobilisation for lower limb injuries—survey of current practice in United Kingdom. Injury. 2006;37(9):813–7.PubMedCrossRef Batra S, Kurup H, Gul A, Andrew JG. Thromboprophylaxis following cast immobilisation for lower limb injuries—survey of current practice in United Kingdom. Injury. 2006;37(9):813–7.PubMedCrossRef
75.
76.
go back to reference Kujath P, Spannagel U, Habscheid W, Schindler G, Weckbach A. Thrombosis prevention in outpatients with lower limb injuries. Dtsch Med Wochenschr. 1992;117(1):6–10.PubMedCrossRef Kujath P, Spannagel U, Habscheid W, Schindler G, Weckbach A. Thrombosis prevention in outpatients with lower limb injuries. Dtsch Med Wochenschr. 1992;117(1):6–10.PubMedCrossRef
77.
go back to reference Warlow C, Ogston D, Douglas AS. Deep venous thrombosis of the legs after strokes. Part I—incidence and predisposing factors. Br Med J. 1976;1:1178–81.PubMedCrossRef Warlow C, Ogston D, Douglas AS. Deep venous thrombosis of the legs after strokes. Part I—incidence and predisposing factors. Br Med J. 1976;1:1178–81.PubMedCrossRef
78.
go back to reference Patel A, Fuchs GJ. Air travel and thromboembolic complications after percutaneous nephrolithotomy for staghorn stone. J Endourol. 1998;12(1):51–3.PubMedCrossRef Patel A, Fuchs GJ. Air travel and thromboembolic complications after percutaneous nephrolithotomy for staghorn stone. J Endourol. 1998;12(1):51–3.PubMedCrossRef
79.
go back to reference Cruickshank JM, Gorlin R, Jennett B. Air travel and thrombotic episodes: the economy class syndrome. Lancet. 1988;2(8609):497–8.PubMedCrossRef Cruickshank JM, Gorlin R, Jennett B. Air travel and thrombotic episodes: the economy class syndrome. Lancet. 1988;2(8609):497–8.PubMedCrossRef
80.
go back to reference Rohrer MJ, Cutler BS, MacDougall E, Herrmann JB, Anderson FA Jr, Wheeler HB. A prospective study of the incidence of deep venous thrombosis in hospitalized children. J Vasc Surg. 1996;24(1):46–9; discussion 50.PubMedCrossRef Rohrer MJ, Cutler BS, MacDougall E, Herrmann JB, Anderson FA Jr, Wheeler HB. A prospective study of the incidence of deep venous thrombosis in hospitalized children. J Vasc Surg. 1996;24(1):46–9; discussion 50.PubMedCrossRef
Metadata
Title
Deep venous thrombosis following different isolated lower extremity fractures: what is known about prevalences, locations, risk factors and prophylaxis?
Authors
S. Decker
M. J. Weaver
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Trauma and Emergency Surgery / Issue 6/2013
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-013-0266-6

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