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01-02-2019 | Original Article

Towards a universal MRI atlas of the prostate and prostate zones

Comparison of MRI vendor and image acquisition parameters

Authors: Kyle R. Padgett, Ph.D., Amy Swallen, B.S., Sara Pirozzi, B.S., Jon Piper, B.S., Felix M. Chinea, M.D., Matthew C. Abramowitz, M.D., Aaron Nelson, M.D., Alan Pollack, M.D., Ph.D., Radka Stoyanova, Ph.D.

Published in: Strahlentherapie und Onkologie | Issue 2/2019

Abstract

Background and purpose

The aim of this study was to evaluate an automatic multi-atlas-based segmentation method for generating prostate, peripheral (PZ), and transition zone (TZ) contours on MRIs with and without fat saturation (±FS), and compare MRIs from different vendor MRI systems.

Methods

T2-weighted (T2) and fat-saturated (T2FS) MRIs were acquired on 3T GE (GE, Waukesha, WI, USA) and Siemens (Erlangen, Germany) systems. Manual prostate and PZ contours were used to create atlas libraries. As a test MRI is entered, the procedure for atlas segmentation automatically identifies the atlas subjects that best match the test subject, followed by a normalized intensity-based free-form deformable registration. The contours are transformed to the test subject, and Dice similarity coefficients (DSC) and Hausdorff distances between atlas-generated and manual contours were used to assess performance.

Results

Three atlases were generated based on GE_T2 (n = 30), GE_T2FS (n = 30), and Siem_T2FS (n = 31). When test images matched the contrast and vendor of the atlas, DSCs of 0.81 and 0.83 for T2 ± FS were obtained (baseline performance). Atlases performed with higher accuracy when segmenting (i) T2FS vs. T2 images, likely due to a superior contrast between prostate vs. surrounding tissue; (ii) prostate vs. zonal anatomy; (iii) in the mid-gland vs. base and apex. Atlases performance declined when tested with images with differing contrast and MRI vendor. Conversely, combined atlases showed similar performance to baseline.

Conclusion

The MRI atlas-based segmentation method achieved good results for prostate, PZ, and TZ compared to expert contoured volumes. Combined atlases performed similarly to matching atlas and scan type. The technique is fast, fully automatic, and implemented on commercially available clinical platform.

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Title: Towards a universal MRI atlas of the prostate and prostate zones
Comparison of MRI vendor and image acquisition parameters
Authors: Kyle R. Padgett, Ph.D.
Amy Swallen, B.S.
Sara Pirozzi, B.S.
Jon Piper, B.S.
Felix M. Chinea, M.D.
Matthew C. Abramowitz, M.D.
Aaron Nelson, M.D.
Alan Pollack, M.D., Ph.D.
Radka Stoyanova, Ph.D.
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 2/2019
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-018-1348-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Towards a universal MRI atlas of the prostate and prostate zones

Comparison of MRI vendor and image acquisition parameters

Abstract

Background and purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and purpose

Methods

Results

Conclusion

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