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01-04-2015 | Original article

DEGRO practical guidelines for the radiotherapy of non-malignant disorders – Part IV

Symptomatic functional disorders

Authors: Dr. med. Gabriele Reinartz, M.D., Hans Theodor Eich, M.D., Fabian Pohl, M.D., German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD)

Published in: Strahlentherapie und Onkologie | Issue 4/2015

Abstract

Purpose

To summarize the updated DEGRO consensus S2e guideline recommendations for the treatment of benign symptomatic functional disorders with low-dose radiotherapy.

Materials and methods

This overview reports on the role of low-dose radiotherapy in the treatment of functional disorders in cases of heterotopic ossification (HO) and Graves orbitopathy (GO). The most relevant aspects of the DEGRO S2e Consensus Guideline “Radiation Therapy of Benign Diseases 2014” regarding diagnostics, treatment decision, dose prescription, as well as performance of radiotherapy and results are summarized.

Results

For both indications (HO, GO), retrospective and some prospective analyses have shown remarkable effects in terms of symptom relief. Nevertheless, the level of evidence (LoE) and the grade of recommendation (GR) vary: LoE 1–2 and GR A-B (HO), LoE 2 and GR B (GO).

Conclusion

Low-dose radiotherapy for benign symptomatic functional disorders has proven to be effective, according to different authors, for 25–100 % of the patients studied and therefore it may be a reasonable prophylactic and therapeutic option if noninvasive or invasive methods have been used without persistent success.

For HO, a single-fraction dose of 7–8 Gy or fractionated radiation with five fractions of 3.5 Gy is recommended. For GO, single-fraction doses of 0.3–2.0 Gy, and total doses of 2.4–20 Gy/series, applied in one daily fraction are recommended.

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Title: DEGRO practical guidelines for the radiotherapy of non-malignant disorders – Part IV
Symptomatic functional disorders
Authors: Dr. med. Gabriele Reinartz, M.D.
Hans Theodor Eich, M.D.
Fabian Pohl, M.D.
German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD)
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 4/2015
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-014-0789-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

DEGRO practical guidelines for the radiotherapy of non-malignant disorders – Part IV

Symptomatic functional disorders

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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