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Strahlentherapie und Onkologie

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01-04-2014 | Review article

Hippocampus sparing in whole-brain radiotherapy

A review

Authors: F. Oskan, U. Ganswindt, S.B. Schwarz, F. Manapov, C. Belka, M. Niyazi

Published in: Strahlentherapie und Onkologie | Issue 4/2014

Abstract

Radiation treatment techniques for whole-brain radiation therapy (WBRT) have not changed significantly since development of the procedure. However, the recent development of novel techniques such as intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT) and helical tomotherapy, as well as an increasing body of evidence concerning neural stem cells (NSCs) have altered the conventional WBRT treatment paradigm. In this regard, hippocampus-sparing WBRT is a novel technique that aims to spare critical hippocampus regions without compromising tumour control. Published data on this new technique are limited to planning and feasibility studies; data on patient outcome are still lacking. However, several prospective trials to analyse the feasibility of this technique and to document clinical outcome in terms of reduced neurotoxicity are ongoing.

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Title: Hippocampus sparing in whole-brain radiotherapy
A review
Authors: F. Oskan
U. Ganswindt
S.B. Schwarz
F. Manapov
C. Belka
M. Niyazi
Publication date: 01-04-2014
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 4/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-013-0518-8

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Hippocampus sparing in whole-brain radiotherapy

A review

Abstract

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Abstract

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