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01-08-2013 | Original article

Reirradiation for recurrent malignant brain tumor with radiotherapy or proton beam therapy

Technical considerations based on experience at a single institution

Authors: M. Mizumoto, MD, T. Okumura, MD, E. Ishikawa, MD, T. Yamamoto, MD, S. Takano, MD, A. Matsumura, MD, Y. Oshiro, MD, H. Ishikawa, MD, H. Sakurai, MD, K. Tsuboi, MD, PhD

Published in: Strahlentherapie und Onkologie | Issue 8/2013

Abstract

Background and purpose

Radiotherapy for recurrent malignant brain tumors is usually limited because of the dose tolerance of the normal brain tissue. The goal of the study was to evaluate the efficacy and feasibility of reirradiation for patients with recurrent malignant brain tumors.

Patients and methods

The subjects comprised 26 patients with recurrent malignant brain tumors treated with conventional radiotherapy (RT, n = 8), stereotactic radiotherapy (SRT, n = 10), and proton beam therapy (PBT, n = 8) at our institute. Fifteen patients had glioblastoma, 6 had WHO grade 3 glioma, and 5 had other tumors. The dose of initial radiotherapy was 34.5–94.4 Gy. Different radiation schedules were compared using the equivalent dose in 2-Gy fractions.

Results

Reirradiation was completed in all patients without a severe acute reaction. The reirradiation doses were 30–60 Gy (median, 42.3 Gy) and the total doses for the initial and second treatments were 64.5–150.4 Gy (median, 100.0 Gy). Currently, 11 patients are alive (median follow-up period, 19.4 months) and 15 are dead. The median survival and local control periods after reirradiation of the 26 patients were 18.3 and 9.3 months, respectively. For the 15 patients with glioblastoma, these periods were 13.1 and 11.0 months, respectively. Two patients showed radiation necrosis that was treated by surgery or conservative therapy.

Conclusion

Reirradiation for recurrent malignant brain tumor using conventional RT, SRT, or PBT was feasible and effective in selected cases. Further investigation is needed for treatment optimization for a given patient and tumor condition.

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Title: Reirradiation for recurrent malignant brain tumor with radiotherapy or proton beam therapy
Technical considerations based on experience at a single institution
Authors: M. Mizumoto, MD
T. Okumura, MD
E. Ishikawa, MD
T. Yamamoto, MD
S. Takano, MD
A. Matsumura, MD
Y. Oshiro, MD
H. Ishikawa, MD
H. Sakurai, MD
K. Tsuboi, MD, PhD
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 8/2013
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-013-0390-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Reirradiation for recurrent malignant brain tumor with radiotherapy or proton beam therapy

Technical considerations based on experience at a single institution

Abstract

Background and purpose

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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