Published in:
01-11-2012 | Review article
Anti-inflammatory effects of low-dose radiotherapy
Indications, dose, and radiobiological mechanisms involved
Authors:
M. Arenas, M.D., Ph.D., S. Sabater, M.D., V. Hernández, M.D., A. Rovirosa, M.D., Ph.D., P.C. Lara, A. Biete, J. Panés, M.D., Ph.D.
Published in:
Strahlentherapie und Onkologie
|
Issue 11/2012
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Abstract
Low-dose radiotherapy (LD-RT) has been used for several benign diseases, including arthrodegenerative and inflammatory pathologies. Despite its effectiveness in clinical practice, little is known about the mechanisms through which LD-RT modulates the various phases of the inflammatory response and about the optimal dose fractionation. The objective of this review is to deepen knowledge about the most effective LD-RT treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies.