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International Journal of Public Health
Published in: International Journal of Public Health 3/2012

01-06-2012 | Original Article

Pandemic and seasonal vaccine coverage and effectiveness during the 2009–2010 pandemic influenza in an Italian adult population

Authors: Simona Costanzo, Francesco Gianfagna, Mariarosaria Persichillo, Francesca D Lucia, Angelita Verna, Modjenar Djidingar, Sara Magnacca, Francesca Bracone, Marco Olivieri, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello

Published in: International Journal of Public Health | Issue 3/2012

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Abstract

Objectives

To evaluate the response to pandemic vaccination and seasonal and pandemic vaccine effectiveness (VE) in an Italian adult population, during the 2009–2010 influenza season.

Methods

Data were recorded by interviewing 19,275 subjects (≥35 years), randomly recruited from the general population of the Moli-sani project. Events [influenza-like illness (ILI), hospitalization and death], which had occurred between 1 November 2009 and 31 January 2010 were considered. VE was analyzed by multivariable Poisson regression analysis.

Results

Pandemic vaccine coverage was very low (2.4%) in subjects at high-flu risk, aged 35–65 years (N = 8,048); there was no significant preventive effect of vaccine against ILI.
Seasonal vaccine coverage was 26.6% in the whole population (63% in elderly and 21.9% in middle-aged subjects at high-flu risk). There was a higher risk to develop ILI in middle-age [VE: −17% (95% CI: −35,−1)] or at high flu-risk [VE: −17% (95% CI: −39, 2)] vaccinated groups.

Conclusions

Coverage of pandemic vaccine was very low in a Southern Italy population, with no protective effect against ILI.
Appendix
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Metadata
Title
Pandemic and seasonal vaccine coverage and effectiveness during the 2009–2010 pandemic influenza in an Italian adult population
Authors
Simona Costanzo
Francesco Gianfagna
Mariarosaria Persichillo
Francesca D Lucia
Angelita Verna
Modjenar Djidingar
Sara Magnacca
Francesca Bracone
Marco Olivieri
Maria Benedetta Donati
Giovanni de Gaetano
Licia Iacoviello
Publication date
01-06-2012
Publisher
SP Birkhäuser Verlag Basel
Published in
International Journal of Public Health / Issue 3/2012
Print ISSN: 1661-8556
Electronic ISSN: 1661-8564
DOI
https://doi.org/10.1007/s00038-012-0346-0

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