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Inflammation Research
Published in: Inflammation Research 2/2016

01-02-2016 | Original Research Paper

Midkine in vitamin D deficiency and its association with anti-Saccharomyces cerevisiae antibodies

Authors: F. B. Serinkan Cinemre, Hakan Cinemre, Cengiz Karacaer, Birsen Aydemir, Ahmet Nalbant, Tezcan Kaya, Ali Tamer

Published in: Inflammation Research | Issue 2/2016

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Abstract

Objectives and design

The growth factor midkine (MK) is a protein that is involved in cancer, inflammation, immunity. Vitamin D is a potent immunomodulator. Anti-Saccharomyces cerevisiae antibody (ASCA) is reported in autoimmune disorders, some of which are among the causes of vitamin D deficiency. The objective of this study was to investigate a possible association of MK and ASCA with vitamin D deficiency.

Materials and methods

208 adults presented to internal medicine outpatient clinic for history and physical examination has been studied. Serum biochemistry, vitamin D, MK, ASCA-IgG and -IgA, IL-1β, IL-6, IL-8, TNF-α, PDGF, VEGF were obtained.

Results

Vitamin D deficiency was 74.2 %. Serum MK level was significantly higher in vitamin D-deficient compared to vitamin D-sufficient individuals (1138.1 ± 262.8 vs 958.6 ± 189 pg/mL, respectively; P < 0.009). Serum MK levels were also significantly higher in both ASCA-IgG and -IgA positives compared to negatives (1318.5 ± 160.3 vs 1065.5 ± 256.1, P = 0.008 and 1347.7 ± 229.7 vs 1070.1 ± 250.9 pg/mL, P = 0.011, respectively). Vitamin D was significantly lower in ASCA positives (P = 0.044).Vitamin D showed positive correlation with IL-1β (r 0.338, P < 0.009) and negative correlation with VEGF (r −0.366, P < 0.004).

Conclusions

MK was significantly elevated in vitamin D deficiency and associated with ASCA positivity which was significantly increased in vitamin D deficiency. These findings suggested that molecular mechanism of vitamin D deficiency may be related with some inflammatory processes.
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Metadata
Title
Midkine in vitamin D deficiency and its association with anti-Saccharomyces cerevisiae antibodies
Authors
F. B. Serinkan Cinemre
Hakan Cinemre
Cengiz Karacaer
Birsen Aydemir
Ahmet Nalbant
Tezcan Kaya
Ali Tamer
Publication date
01-02-2016
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 2/2016
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-015-0898-6

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