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Inflammation Research
Published in: Inflammation Research 5/2015

01-05-2015 | Short Communication

H3 receptor renal expression in normal and diabetic rats

Authors: Alessandro Pini, Paul L. Chazot, Eleonora Veglia, Aldo Moggio, Arianna Carolina Rosa

Published in: Inflammation Research | Issue 5/2015

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Abstract

Introduction

To extend our previous observation of H4R upregulation in the kidney of diabetic rats, we evaluated in the same specimens the presence of the H3R.

Materials and methods

Kidney specimens from 24 8-week-old male Wistar rats (12 non-diabetic and 12 diabetic animals) were processed for both immunohistochemical and immunofluorescence analyses.

Results and conclusion

H3R is expressed in the apical membrane by collecting duct cells in the kidney of rats and it is significantly increased in diabetic animals. These data support the hypothesis that H3R could also mediate non-neuronal histamine effects, suggesting its involvement in fluid homeostasis.
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Metadata
Title
H3 receptor renal expression in normal and diabetic rats
Authors
Alessandro Pini
Paul L. Chazot
Eleonora Veglia
Aldo Moggio
Arianna Carolina Rosa
Publication date
01-05-2015
Publisher
Springer Basel
Published in
Inflammation Research / Issue 5/2015
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-015-0808-y

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