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Inflammation Research
Published in: Inflammation Research 12/2012

01-12-2012 | Short Communication

Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide

Authors: David Dubayle, Anne Héron

Published in: Inflammation Research | Issue 12/2012

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Abstract

Introduction

The mast cell is an immunocyte, but its functions in the brain remain unclear.

Materials and methods

In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.

Conclusion

We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.
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Metadata
Title
Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide
Authors
David Dubayle
Anne Héron
Publication date
01-12-2012
Publisher
SP Birkhäuser Verlag Basel
Published in
Inflammation Research / Issue 12/2012
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-012-0565-0

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