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Inflammation Research
Published in: Inflammation Research 2/2010

01-03-2010 | Short Communication

Expression and function of histamine H4 receptor in mouse splenic dendritic cells

Authors: T. Simon, I. Jelinek, Gy. Apponyi, V. László, É. Rajnavölgyi, A. Falus

Published in: Inflammation Research | Special Issue 2/2010

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Excerpt

Dendritic cells (DC) are the master regulators of the immune system. DCs act as “sentinels” and they are the most potent antigen-presenting cells specialized for capture, transport, processing and presentation of antigens [1]. During these activities numerous factors may influence their functions. Histamine is one of these mediators released from neighboring mast cells, basophils, and even from the DCs themselves [2]. …
Literature
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Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest. 2001;108:1865–73.PubMed
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Coge F, Guenin SP, Rique H, Boutin JA, Galizzi JP. Structure and expression of the human histamine H4-receptor gene. Biochem Biophys Res Commun. 2001;284:301–9.CrossRefPubMed
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Connelly WM, Shenton FC, Lethbridge N, Leurs R, Waldvogel HJ, Faull RL, et al. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol. 2009;157:55–63.CrossRefPubMed
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Bäumer W, Wendorff S, Gutzmer R, Werfel T, Dijkstra D, Chazot P, et al. Histamine H4 receptors modulate dendritic cell migration through skin––immunomodulatory role of histamine. Allergy. 2008;63:1387–94.CrossRefPubMed
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Jelinek I, László V, Buzás E, Pállinger E, Hangya B, Horváth Z, et al. Increased antigen presentation and T(h)1 polarization in genetically histamine-free mice. Int Immunol. 2007;19:51–8.CrossRefPubMed
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van Rijk RM, Chazot PL, Shenton FC, Sansuk K, Bakker RA, Leurs R. Oligomerization of recombinant and endogenously expressed human histamine H4 receptor. Mol Pharmacol. 2006;70:604–15.CrossRef
Metadata
Title
Expression and function of histamine H4 receptor in mouse splenic dendritic cells
Authors
T. Simon
I. Jelinek
Gy. Apponyi
V. László
É. Rajnavölgyi
A. Falus
Publication date
01-03-2010
Publisher
SP Birkhäuser Verlag Basel
Published in
Inflammation Research / Issue Special Issue 2/2010
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-009-0130-7

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