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General Thoracic and Cardiovascular Surgery

26-04-2024 | Colorectal Cancer | Original Article

Prognostic factors in pulmonary metastases resection from colorectal cancer: impact of right-sided colon cancer and early recurrence

Authors: Yo Tsukamoto, Takeo Nakada, Rintaro Shigemori, Daiki Kato, Takamasa Shibazaki, Shohei Mori, Makoto Odaka, Takashi Ohtsuka

Published in: General Thoracic and Cardiovascular Surgery

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Abstract

Objective

This retrospective cohort study aimed to explore the surgical outcomes and prognostic factors of resection of pulmonary metastases (PM) from colorectal cancer (CRC).

Methods

Overall, 60 patients who underwent resection of PM from CRC between 2015 and 2021 at two institutions were reviewed. The primary outcome were overall survival (OS) and early recurrence after PM resection. The association between OS and right-sided colon cancer (RCC) was investigated. Early recurrence after PM resection was defined as recurrence within one year.

Results

The 5-year OS after CRC resection was 83.8% (95% confidence interval [CI] 67.5–92.4) and after PM resection was 69.4% (95% CI 47.5–83.6). In total, 25 patients had recurrence after PM resection (16 within 1 year and 9 after 1 year). In multivariable analysis for OS, RCC (hazard ratio [HR] 4.370, 95% CI 1.020–18.73; p = 0.047) and early recurrence after resection of PM (HR 17.23, 95% CI 2.685–110.6; p = 0.003) were risk factors for poor OS. In multivariable analysis for early recurrence after PM resection, higher value of carcinoembryonic antigen (CEA) (> 5.0 mg/dL) before PM resection was a risk factor for early recurrence (HR 3.275, 95% CI 1.092–9.821; p = 0.034).

Conclusion

The RCC and early recurrence after PM resection were poor prognosis factors of OS. Higher value of CEA before PM resection was an independent risk factor for early recurrence after resection of PM. Comparitive study between surgery and nonsurgery is necessary in patients with higher CEA values.
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Metadata
Title
Prognostic factors in pulmonary metastases resection from colorectal cancer: impact of right-sided colon cancer and early recurrence
Authors
Yo Tsukamoto
Takeo Nakada
Rintaro Shigemori
Daiki Kato
Takamasa Shibazaki
Shohei Mori
Makoto Odaka
Takashi Ohtsuka
Publication date
26-04-2024
Publisher
Springer Nature Singapore
Published in
General Thoracic and Cardiovascular Surgery
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-024-02035-9