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Journal of Cardiothoracic Surgery
Published in: Journal of Cardiothoracic Surgery 1/2024

Open Access 01-12-2024 | Abdominal Aortic Aneurysm | Research

Postoperative serum mir-28-5p level has predictive value for the prognosis after endovascular abdominal aortic aneurysm repair

Authors: Senyan Wu, Guobing Cheng, Wei Lu, Youyao Xu

Published in: Journal of Cardiothoracic Surgery | Issue 1/2024

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Abstract

Background

We explored the clinical significance of miR-28-5p pre- and post-endovascular abdominal aortic aneurysm repair (EVAR) in abdominal aortic aneurysm (AAA) patients.

Methods

Subjects included AAA patients receiving EVAR and non-AAA people without statistical differences from AAA patient in comorbidities/Framingham risk score. Fasting elbow venous blood (4 mL) was collected in the morning of the day of EVAR surgery and in the morning of 3 months post-EVAR. Pre-/post-EVAR serum miR-28-5p expression, AAA maximum diameter alterations, CD3+/CD4+/CD8+/TC/TG pre-/post-EVAR, and the correlations between miR-28-5p and AAA maximum diameter were investigated. Prediction of miR-28-5p on post-EVAR mortality, prognosis, and independent factors of post-EVAR death were analyzed using receiver operating characteristic curve (ROC)/Kaplan-Meier curve/univariable and multivariable Cox regression. According to the cut-off value of ROC curve for postoperative miR-28-5p was the cut-off value, and the patients were classified into the miR-28-5p high- and low-expression groups. The survival or death of both groups were compared after 48-month follow-up.

Results

Serum miR-28-5p levels in AAA patients dropped post-EVAR. AAA patients showed notable differences in CD3+/CD4+/CD8+/TC/TG levels pre-/post-EVAR. The miR-28-5p low-expression group exhibited higher CD3+/CD4+ and lower CD8+/TC/TG levels. We observed a positive correlation between post-EVAR miR-28-5p and AAA maximum diameter and between the pre-/post-EVAR miR-28-5p fold change and the AAA maximum diameter change. Postoperative miR-28-5p demonstrated good predictive value for postoperative death. Hypertension, Framingham risk score, TC, TG, and miR-28-5p were independent influencing factors of post-EVAR death.

Conclusion

EVAR decreased serum miR-28-5p expression in AAA patients. Post-operative miR-28-5p level and pre-/post-operative fold change level are positively-correlated with AAA diameter.
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Literature
1.
Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16(4):225–42.CrossRefPubMed
2.
Derezinski TL, Formankiewicz B, Migdalski A, Brazis P, Jakubowski G, Woda L, et al. The prevalence of abdominal aortic aneurysms in the rural/urban population in central Poland - Gniewkowo aortic study. Kardiol Pol. 2017;75(7):705–10.CrossRefPubMed
3.
Gao JP, Guo W. Mechanisms of abdominal aortic aneurysm progression: a review. Vasc Med. 2022;27(1):88–96.CrossRefPubMed
4.
Tchana-Sato V, Sakalihasan N, Defraigne JO. [Ruptured abdominal aortic aneurysm]. Rev Med Liege. 2018;73(5–6):296–9.PubMed
5.
Ngetich E, Lapolla P, Chandrashekar A, Handa A, Lee R. The role of dipeptidyl peptidase-IV in abdominal aortic aneurysm pathogenesis: a systematic review. Vasc Med. 2022;27(1):77–87.CrossRefPubMed
6.
Ouriel K. The PIVOTAL study: a randomized comparison of endovascular repair versus surveillance in patients with smaller abdominal aortic aneurysms. J Vasc Surg. 2009;49(1):266–9.CrossRefPubMed
7.
Kinio A, Ramsay T, Jetty P, Nagpal S. Declining institutional memory of open abdominal aortic aneurysm repair. J Vasc Surg. 2021;73(3):889–95.CrossRefPubMed
8.
Kim CW, Kumar S, Son DJ, Jang IH, Griendling KK, Jo H. Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arterioscler Thromb Vasc Biol. 2014;34(7):1412–21.CrossRefPubMedPubMedCentral
9.
Adam M, Raaz U, Spin JM, Tsao PS. MicroRNAs in abdominal aortic aneurysm. Curr Vasc Pharmacol. 2015;13(3):280–90.CrossRefPubMed
10.
Tsai HY, Wang JC, Hsu YJ, Chiu YL, Lin CY, Lu CY, et al. miR-424/322 protects against abdominal aortic aneurysm formation by modulating the Smad2/3/runt-related transcription factor 2 axis. Mol Ther Nucleic Acids. 2022;27:656–69.CrossRefPubMed
11.
Yang Z, Zhang L, Liu Y, Zeng W, Wang K. Potency of mir-144-3p in promoting abdominal aortic aneurysm progression in mice correlates with apoptosis of smooth muscle cells. Vascul Pharmacol. 2022;142:106901.CrossRefPubMed
12.
Shen G, Sun Q, Yao Y, Li S, Liu G, Yuan C, et al. Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm. Atherosclerosis. 2020;297:47–54.CrossRefPubMed
13.
Torres-Do Rego A, Barrientos M, Ortega-Hernandez A, Modrego J, Gomez-Gordo R, Alvarez-Sala LA et al. Identification of a plasma Microrna signature as Biomarker of Subaneurysmal aortic dilation in patients with High Cardiovascular Risk. J Clin Med. 2020;9(9).
14.
Yue J, Zhu T, Yang J, Si Y, Xu X, Fang Y, et al. CircCBFB-mediated mir-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4. Life Sci. 2020;253:117533.CrossRefPubMed
15.
Onrat ST, Onrat E, Ercan Onay E, Yalim Z, Avsar A. The genetic determination of the differentiation between ischemic dilated cardiomyopathy and idiopathic dilated cardiomyopathy. Genet Test Mol Biomarkers. 2018;22(11):644–51.CrossRefPubMed
16.
Liu Q, Yan S, Yuan Y, Ji S, Guo L. Mir-28-5p improved carotid artery stenosis by regulating vascular smooth muscle cell proliferation and migration. Vascular. 2022;30(4):764–70.CrossRefPubMed
17.
Zhang W, Shang T, Huang C, Yu T, Liu C, Qiao T, et al. Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm. Clin Biochem. 2015;48(15):988–92.CrossRefPubMed
18.
Iyer V, Rowbotham S, Biros E, Bingley J, Golledge J. A systematic review investigating the association of microRNAs with human abdominal aortic aneurysms. Atherosclerosis. 2017;261:78–89.CrossRefPubMed
19.
Stather PW, Sylvius N, Sidloff DA, Dattani N, Verissimo A, Wild JB, et al. Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease. Br J Surg. 2015;102(7):755–66.CrossRefPubMed
20.
Yan H, Jiang H, Xia Q, Shan W, Zhang L, Zhao F. Effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm. Am J Transl Res. 2021;13(3):1808–16.PubMedPubMedCentral
21.
Chen Y, Huang M, Xuan Y, Li K, Xu X, Wang L et al. Association between lipid levels and risk for different types of aneurysms: a mendelian randomization study. J Pers Med. 2021;11(11).
22.
Li J, Zhou ZX, Cheng YJ, Wang YW, Guan XM, Wang HF. Altered patterns of gene expression distinguishing unruptured abdominal aortic aneurysms from ruptured ones: comprehensive analysis of inflammatory factors. Int J Clin Exp Pathol. 2017;10(8):8553–60.PubMedPubMedCentral
23.
Zampetaki A, Attia R, Mayr U, Gomes RS, Phinikaridou A, Yin X, et al. Role of miR-195 in aortic aneurysmal disease. Circ Res. 2014;115(10):857–66.CrossRefPubMed
24.
Licholai S, Szczeklik W, Sanak M. miR-29c-3p is an effective biomarker of abdominal aortic aneurysm in patients undergoing elective surgery. Microrna. 2016;5(2):124–31.CrossRefPubMed
25.
Zarins CK, Crabtree T, Bloch DA, Arko FR, Ouriel K, White RA. Endovascular aneurysm repair at 5 years: does aneurysm diameter predict outcome? J Vasc Surg. 2006;44(5):920–29. discussion 9–31.CrossRefPubMed
26.
Ouriel K, Clair DG, Kent KC, Zarins CK. Positive impact of Endovascular options for treating Aneurysms Early I. Endovascular repair compared with surveillance for patients with small abdominal aortic aneurysms. J Vasc Surg. 2010;51(5):1081–7.CrossRefPubMed
27.
Rodway AD, Powell JT, Brown LC, Greenhalgh RM. Do abdominal aortic aneurysm necks increase in size faster after endovascular than open repair? Eur J Vasc Endovasc Surg. 2008;35(6):685–93.CrossRefPubMed
28.
Investigators IT, Powell JT, Sweeting MJ, Thompson MM, Ashleigh R, Bell R, et al. Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial. BMJ. 2014;348:f7661.CrossRef
29.
Eisenstein EL, Davidson-Ray L, Edwards R, Anstrom KJ, Ouriel K. Economic analysis of endovascular repair versus surveillance for patients with small abdominal aortic aneurysms. J Vasc Surg. 2013;58(2):302–10.CrossRefPubMed
30.
Brady AR, Fowkes FG, Greenhalgh RM, Powell JT, Ruckley CV, Thompson SG. Risk factors for postoperative death following elective surgical repair of abdominal aortic aneurysm: results from the UK Small Aneurysm Trial. On behalf of the UK Small Aneurysm Trial participants. Br J Surg. 2000;87(6):742–9.CrossRefPubMed
31.
Grimes JA, Lourenco BN, Coleman AE, Rissi DR, Schmiedt CW. MicroRNAs are differentially expressed in the serum and renal tissues of cats with experimentally induced chronic kidney disease: a preliminary study. Am J Vet Res. 2022;83(5):426–33.CrossRefPubMed
32.
Plana E, Galvez L, Medina P, Navarro S, Fornes-Ferrer V, Panadero J et al. Identification of Novel microRNA profiles dysregulated in plasma and tissue of abdominal aortic aneurysm patients. Int J Mol Sci. 2020;21(13).
33.
Lareyre F, Clement M, Moratal C, Loyer X, Jean-Baptiste E, Hassen-Khodja R, et al. Differential micro-RNA expression in diabetic patients with abdominal aortic aneurysm. Biochimie. 2019;162:1–7.CrossRefPubMed
34.
Meng C, Guo Z, Li D, Li H, Zhou J, Wen D, et al. miR-183 and miR-141 in lesion tissues are potential risk factors for poor prognosis in patients with infected abdominal aortic aneurysm. Exp Ther Med. 2018;16(6):4695–9.PubMedPubMedCentral
35.
Schanzer A, Greenberg RK, Hevelone N, Robinson WP, Eslami MH, Goldberg RJ, et al. Predictors of abdominal aortic aneurysm sac enlargement after endovascular repair. Circulation. 2011;123(24):2848–55.CrossRefPubMed
36.
van Rijswijk RE, Groot Jebbink E, Holewijn S, Stoop N, van Sterkenburg SM, Reijnen M. Predictors of abdominal aortic aneurysm shrinkage after Endovascular Repair. J Clin Med. 2022;11(5).
Metadata
Title
Postoperative serum mir-28-5p level has predictive value for the prognosis after endovascular abdominal aortic aneurysm repair
Authors
Senyan Wu
Guobing Cheng
Wei Lu
Youyao Xu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2024
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-024-02758-z

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