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Japanese Journal of Radiology

Open Access 25-04-2024 | Neck Dissection | Original Article

FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F‑FDG‑PET/CT

Authors: Yukako Iritani, Hiroki Kato, Yo Kaneko, Takuma Ishihara, Tomohiro Ando, Masaya Kawaguchi, Hirofumi Shibata, Takenori Ogawa, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo

Published in: Japanese Journal of Radiology

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Abstract

Purpose

This study aimed to assess the imaging features and postoperative natural course of 18F-fluorodeoxyglucose (FDG) uptake in the cervical muscles after neck dissection.

Materials and methods

This study included 83 patients who underwent preoperative and postoperative 18F-FDG-PET/CT and were diagnosed with head and neck malignancy after neck dissection. Postoperative 18F-FDG-PET/CT was performed within 5 years after neck dissection. Preoperative and postoperative FDG uptake of the trapezius, sternocleidomastoid, scalene, pectoralis major, and deltoid muscles was visually assessed. Increased postoperative uptake was visually defined as higher postoperative FDG uptake than the preoperative one in the corresponding muscle. The maximum standardized uptake value (SUVmax) was measured in cases with increased postoperative uptakes.

Results

Increased postoperative uptakes were observed in 43 patients (52%). The trapezius (31/83, 37%), sternocleidomastoid (19/83, 23%), and scalene (12/83, 14%) muscles were involved, as opposed to the pectoralis major and deltoid muscles were not. Increased postoperative uptakes were observed on the dissected side in all 43 patients. Significant differences between SUVmax estimated from the mixed-effects model and postoperative months were observed in the trapezius muscle (Coefficient (β) = −0.038; 95% confidence interval (CI): [−0.047, −0.028]; p < 0.001) and sternocleidomastoid muscle (β =  −0.015; 95% CI: [−0.029, −0.001]; p = 0.046).

Conclusions

Increased postoperative uptakes in the cervical muscles were observed on the dissected side in approximately half of the patients after neck dissection. The SUVmax in the trapezius and sternocleidomastoid muscles decreased after surgery over time.
Literature
1.
Lee SH, Oh BM, Lee G, Choi H, Cheon GJ, Lee SU. Feasibility of 18F-FDG PET as a noninvasive diagnostic tool of muscle denervation: a preliminary study. J Nucl Med. 2014;55(10):1737–40.CrossRefPubMed
2.
Pak K, Shin MJ, Hwang SJ, et al. Longitudinal changes in glucose metabolism of denervated muscle after complete peripheral nerve injury. Mol Imaging Biol. 2016;18(5):741–7.CrossRefPubMed
3.
Choi JS, Seo HG, Oh BM, et al. (18) F-FDG uptake in denervated muscles of patients with peripheral nerve injury. Ann Clin Transl Neurol. 2019;6(11):2175–85.CrossRefPubMedPubMedCentral
4.
Lee SH, Seo HG, Oh BM, Choi H, Cheon GJ, Lee SU. 18F-FDG positron emission tomography as a novel diagnostic tool for peripheral nerve injury. J Neurosci Methods. 2019;317:11–9.CrossRefPubMed
5.
Kito S, Koga H, Kodama M, et al. Alterations in 18F-FDG accumulation into neck-related muscles after neck dissection for patients with oral cancers. Med Oral Patol Oral Cir Bucal. 2016;21(3):e341–8.CrossRefPubMedPubMedCentral
6.
Kito S, Koga H, Oda M, et al. Changes in the distributions of fluorine-18-labelled fluoro-2-deoxy-d-glucose accumulation into tongue-related muscles after dissection in patients with tongue cancer. Dentomaxillofac Radiol. 2017;46(6):20160396.CrossRefPubMedPubMedCentral
7.
Lee SH, Seo HG, Oh BM, Choi H, Cheon GJ, Lee SU. Increased 18F-FDG uptake in the trapezius muscle in patients with spinal accessory neuropathy. J Neurol Sci. 2016;362:127–30.CrossRefPubMed
8.
Karunanithi S, Soundararajan R, Sharma P, Naswa N, Bal C, Kumar R. Spectrum of physiologic and pathologic skeletal muscle 18F-FDG uptake on PET/CT. AJR Am J Roentgenol. 2015;205(2):W141–9.CrossRefPubMed
9.
Parida GK, Roy SG, Kumar R. FDG-PET/CT in skeletal muscle: pitfalls and pathologies. Semin Nucl Med. 2017;47(4):362–72.CrossRefPubMed
10.
Tsuji T, Tanuma A, Onitsuka T, et al. Electromyographic findings after different selective neck dissections. Laryngoscope. 2007;117(2):319–22.CrossRefPubMed
11.
Fischbein NJ, Kaplan MJ, Jackler RK, Dillon WP. MR imaging in two cases of subacute denervation change in the muscles of facial expression. AJNR Am J Neuroradiol. 2001;22(5):880–4.PubMedPubMedCentral
12.
Dilber M, Kasapoglu F, Erisen L, Basut O, Tezel I. The relationship between shoulder pain and damage to the cervical plexus following neck dissection. Eur Arch Otorhinolaryngol. 2007;264(11):1333–8.CrossRefPubMed
Metadata
Title
FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F‑FDG‑PET/CT
Authors
Yukako Iritani
Hiroki Kato
Yo Kaneko
Takuma Ishihara
Tomohiro Ando
Masaya Kawaguchi
Hirofumi Shibata
Takenori Ogawa
Yoshifumi Noda
Fuminori Hyodo
Masayuki Matsuo
Publication date
25-04-2024
Publisher
Springer Nature Singapore
Published in
Japanese Journal of Radiology
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-024-01568-6