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20-04-2024 | Cytostatic Therapy | Review

Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies

Authors: Ameya A. Asarkar, Brent A. Chang, Remco de Bree, Luiz P. Kowalski, Orlando Guntinas-Lichius, Patrick J. Bradley, Pim de Graaf, Primož Strojan, Karthik N. Rao, Antti A. Mäkitie, Fernando López, Alessandra Rinaldo, Carsten Palme, Eric M. Genden, Alvaro Sanabria, Juan P. Rodrigo, Alfio Ferlito

Published in: Advances in Therapy | Issue 6/2024

Abstract

Introduction

Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.

Methods

A review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.

Results

Studies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.

Conclusion

The management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.

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Title: Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies
Authors: Ameya A. Asarkar
Brent A. Chang
Remco de Bree
Luiz P. Kowalski
Orlando Guntinas-Lichius
Patrick J. Bradley
Pim de Graaf
Primož Strojan
Karthik N. Rao
Antti A. Mäkitie
Fernando López
Alessandra Rinaldo
Carsten Palme
Eric M. Genden
Alvaro Sanabria
Juan P. Rodrigo
Alfio Ferlito
Publication date: 20-04-2024
Publisher: Springer Healthcare
Keyword: Cytostatic Therapy
Published in: Advances in Therapy / Issue 6/2024
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI: https://doi.org/10.1007/s12325-024-02861-6

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Obesity Clinical Trial Summary

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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