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BMC Urology

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Open Access 01-12-2024 | Urothelial Cancer | Research

Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma

Authors: Yang Yang, Jun Li, Weixiang Yao, Ge Zou, Xuying Ye, Qishan Mo

Published in: BMC Urology | Issue 1/2024

Abstract

Objective

To investigate the diagnostic value of urine cyclic RNA-0071196 (circRNA-0071196) in the patients with bladder urothelial carcinoma (BUC).

Method

The expression of circRNA-0071196 was detected in the urine samples using qRT-PCR from 40 BUC patients and 30 non-UBC patients at our department from December 2018 to September 2021. The expression difference of circRNA-0071196 was compared between the two groups, and the relationship between the expression of circRNA-0071196 in the urine of UBC patients and the clinical pathological characteristics was analyzed.

Results

(1) The expression of circRNA-0071196 in the urine of BUC group was significantly higher than that in the non-BUC group (P < 0.05). (2) The expression of circRNA-0071196 in the urine of BUC group was not related to age, sex, or lymph node metastasis (P > 0.05). (3) The expression of circRNA-0071196 in the urine of BUC group was related to tumor T stage, tumor grade and muscle invasion. (4) The urine circRNA-0071196 expression effectively distinguished BUC patients from non-BUC patients.

Conclusion

The elevated expression of urine circRNA-0071196 in BUC patients indicates that circRNA-0071196 has promising potential as a non-invasive urinary biomarker for detecting BUC.

Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.CrossRefPubMed

Antoni S, Ferlay J, Soerjomataram I, et al. Bladder Cancer incidence and mortality: A global overview and recent trends. Eur Urol. 2017;71(1):96–108.CrossRefPubMed

Babjuk M, Burger M, Compérat EM, et al. European Association of Urology Guidelines on non-muscle-invasive bladder Cancer (TaT1 and Carcinoma in Situ) – 2019 update. Eur Urol. 2019;76(5):639–57.CrossRefPubMed

Zibelman M, Asghar AM, Parker DC, et al. Cystoscopy and systematic bladder tissue sampling in Predicting pT0 bladder Cancer: a prospective trial. J Urol. 2021;205(6):1605–11.CrossRefPubMedPubMedCentral

Hwang EC, Choi HS, Jung SI, et al. Use of the NMP22 BladderChek test in the diagnosis and follow-up of urothelial cancer: a cross-sectional study. Urology. 2011;77(1):154–9.CrossRefPubMed

Sarosdy MF, deVere White RW, Soloway MS, et al. Results of a multicenter trial using the BTA test to monitor for and diagnose recurrent bladder cancer. J Urol. 1995;154(2 Pt 1):379–83.CrossRefPubMed

Li X, Yang L, Chen LL. The Biogenesis, functions, and challenges of Circular RNAs. Mol Cell. 2018;71(3):428–42.CrossRefPubMed

Hansen TB, Kjems J, Damgaard CK. Circular RNA and miR-7 in cancer. Cancer Res. 2013;73(18):5609–12.CrossRefPubMed

Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–8.CrossRefPubMed

10.

Bajo-Santos C, Brokāne A, Zayakin P, et al. Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies. Front Mol Biosci. 2023;10:980433.CrossRefPubMedPubMedCentral

11.

Yafi FA, Brimo F, Steinberg J, et al. Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancer. Urol Oncol. 2015;33(2):e6625–31.CrossRef

12.

Lotan Y, Roehrborn CG. Sensitivity and specificity of commonly available bladder tumor markers versus cytology: results of a comprehensive literature review and meta-analyses. Urology. 2003;61(1):109–18.CrossRefPubMed

13.

Babjuk M, Böhle A, Burger M, et al. EAU guidelines on Non-muscle-invasive Urothelial Carcinoma of the bladder: Update 2016. Eur Urol. 2017;71(3):447–61. https://doi.org/10.1016/j.eururo.2016.05.041. Epub 2016 Jun 17. PMID: 27324428.CrossRefPubMed

14.

Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016 Mar-Apr;66(2):115–32.

15.

Liu Z, Yang Y, Yang Z, et al. Novel circRNA_0071196/miRNA–19b–3p/CIT axis is associated with proliferation and migration of bladder cancer. Int J Oncol. 2020;57(3):767–79.CrossRefPubMedPubMedCentral

16.

Bi W, Huang J, Nie C, et al. CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res. 2018;37(1):275.CrossRefPubMedPubMedCentral

17.

Peter MR, Zhao F, Jeyapala R, et al. Investigating urinary circular RNA biomarkers for Improved Detection of Renal Cell Carcinoma. Front Oncol. 2022;11:814228.CrossRefPubMedPubMedCentral

18.

Kölling M, Haddad G, Wegmann U, et al. Circular RNAs in urine of kidney transplant patients with Acute T cell-mediated allograft rejection. Clin Chem. 2019;65(10):1287–94.CrossRefPubMed

19.

Li J, Sun D, Pu W, et al. Circular RNAs in Cancer: Biogenesis, function, and clinical significance. Trends Cancer. 2020;6(4):319–36.CrossRefPubMed

20.

Zhou P, Xie W, Huang HL, et al. circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway. Aging. 2020;12(13):13338–53.CrossRefPubMedPubMedCentral

21.

Rochow H, Jung M, Weickmann S, et al. Circular RNAs and their Linear transcripts as diagnostic and prognostic tissue biomarkers in prostate Cancer after Prostatectomy in Combination with clinicopathological factors. Int J Mol Sci. 2020;21(21):7812.CrossRefPubMedPubMedCentral

22.

Song Z, Zhang Q, Zhu J, et al. Identification of urinary hsa_circ _0137439 as potential biomarker and tumor regulator of bladder cancer. Neoplasma. 2020;67(1):137–46.CrossRefPubMed

23.

Li J, Li Z, Jiang P, et al. Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. J Exp Clin Cancer Res. 2018;37(1):177.CrossRefPubMedPubMedCentral

Title: Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma
Authors: Yang Yang
Jun Li
Weixiang Yao
Ge Zou
Xuying Ye
Qishan Mo
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Urothelial Cancer
Urothelial Cancer
Published in: BMC Urology / Issue 1/2024
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/s12894-024-01466-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma

Abstract

Objective

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Method

Results

Conclusion

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