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Open Access 01-12-2024 | Tadalafile | Original Research

Tadalafil versus tamsulosin for distal ureteric stone expulsion; a prospective randomized comparative study

Authors: Ahmed M. Ragheb, Ahmed G. Mohamed, Ahmed S. Mostafa, Ahmed Abd Elatif, Akram A. Elmarakbi, Rabie M. Ibrahim, Ahmed M. Elbatanouny

Published in: African Journal of Urology | Issue 1/2024

Abstract

Background

Tamsulosin, an alpha-blocker in medical expulsive therapy, selectively relaxes ureteral smooth muscle, while Tadalafil, a PDE5-Is, is recommended for treating lower urinary tract symptoms.

Methods

This study compares the effectiveness of Tadalafil and Tamsulosin as medical expulsive therapy for distal ureteric stones at the Urology Department, Beni-Suef University Hospital, Egypt, using baseline demographics, preoperative data, intraoperative data, and outcome analysis.

Results

A randomized comparative study that is prospective and was from March 2019 to March 2021. Although 280 instances were eligible, 30 were eliminated & 250 were randomized, and only 164 patients completed the study. 83 patients were in the study Tadalafil group (Group A), 54 males (65.1%) & 29 (34.9%) and 81 patients were assigned to the Tamsulosin group (Group B), 47 males (58%) &34 females made up the Tadalafil group (Group A). The study was completed by 34 females (42%). Additionally, there was a significant difference in the meantime for stone expulsion between groups A (8.8 ± 3.1 days) and B (10.8 ± 3.4 days, (p = 0.001). With fewer episodes of colic, Group A needed less analgesia than Group B.

Conclusions

Tadalafil is a safer and more effective treatment for 5–9 mm lower ureteric end stones, offering a higher stone expulsion rate, earlier passage, lower analgesic requirements, and fewer colic episodes.

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Title: Tadalafil versus tamsulosin for distal ureteric stone expulsion; a prospective randomized comparative study
Authors: Ahmed M. Ragheb
Ahmed G. Mohamed
Ahmed S. Mostafa
Ahmed Abd Elatif
Akram A. Elmarakbi
Rabie M. Ibrahim
Ahmed M. Elbatanouny
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Tadalafile
Tamsulosin
Published in: African Journal of Urology / Issue 1/2024
Print ISSN: 1110-5704
Electronic ISSN: 1961-9987
DOI: https://doi.org/10.1186/s12301-024-00425-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tadalafil versus tamsulosin for distal ureteric stone expulsion; a prospective randomized comparative study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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