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Open Access 02-04-2024 | Acute Pulmonary Embolism | Original Paper

Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism

Authors: Katharina Mohr, Lukas Hobohm, Klaus Kaier, Ioannis T. Farmakis, Luca Valerio, Stefano Barco, Christina Abele, Thomas Münzel, Thomas Neusius, Stavros Konstantinides, Harald Binder, Karsten Keller

Published in: Clinical Research in Cardiology

Abstract

Background and aims

The socio-economic burden imposed by acute pulmonary embolism (PE) on European healthcare systems is largely unknown. We sought to determine temporal trends and identify cost drivers of hospitalisation for PE in Germany.

Methods and results

We analysed the totality of reimbursed hospitalisation costs in Germany (G-DRG system) in the years 2016–2020. Overall, 484 884 PE hospitalisations were coded in this period. Direct hospital costs amounted to a median of 3572 (IQR, 2804 to 5869) euros, resulting in average total reimbursements of 710 million euros annually. Age, PE severity, comorbidities and in-hospital (particularly bleeding) complications were identified by multivariable logistic regression as significant cost drivers. Use of catheter-directed therapy (CDT) constantly increased (annual change in the absolute proportion of hospitalisations with CDT + 0.40% [95% CI + 0.32% to + 0.47%]; P < 0.001), and it more than doubled in the group of patients with severe PE (28% of the entire population) over time. Although CDT use was overall associated with increased hospitalisation costs, this association was no longer present (adjusted OR 1.02 [0.80–1.31]) in patients with severe PE and shock; this was related, at least in part, to a reduction in the median length of hospital stay (for 14.0 to 8.0 days).

Conclusions

We identified current and emerging cost drivers of hospitalisation for PE, focusing on severe disease and intermediate/high risk of an adverse early outcome. The present study may inform reimbursement decisions by policymakers and help to guide future health economic analysis of advanced treatment options for patients with PE.

Graphical Abstract

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Title: Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism
Authors: Katharina Mohr
Lukas Hobohm
Klaus Kaier
Ioannis T. Farmakis
Luca Valerio
Stefano Barco
Christina Abele
Thomas Münzel
Thomas Neusius
Stavros Konstantinides
Harald Binder
Karsten Keller
Publication date: 02-04-2024
Publisher: Springer Berlin Heidelberg
Keywords: Acute Pulmonary Embolism
Acute Pulmonary Embolism
Acute Pulmonary Embolism
Shock
Shock
Published in: Clinical Research in Cardiology
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-024-02437-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism

Abstract

Background and aims

Methods and results

Conclusions

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and aims

Methods and results

Conclusions

Graphical Abstract

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