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Clinical Oral Investigations
Published in: Clinical Oral Investigations 4/2024

01-04-2024 | Oral Cancer | RESEARCH

Second primary squamous cell carcinoma of the oral cavity – a retrospective cohort study of therapeutic procedures and oncological outcome

Authors: Julius Moratin, Theresa Maas, Dominik Horn, Karl Semmelmayer, Sven Zittel, Marcel Oehme, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger, Kolja Freier, Oliver Ristow

Published in: Clinical Oral Investigations | Issue 4/2024

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Abstract

Objectives

In the presented study, the occurrence rates of second primary oral carcinomas and their prognostic relevance were analyzed.

Materials and methods

All patients with surgically treated oral squamous cell carcinomas within the years 2010 and 2022 in our department were included in this retrospective cohort study. Two groups were designed including patients with second primary carcinomas and patients with local tumor recurrences. Occurrence rates, tumor stages and applied therapies were assessed. Primary outcome was overall survival in dependence of the index tumor. Secondary outcomes were overall survival in dependence of local recurrences or second primary tumors.

Results

An overall number of 908 patients was included in the analysis. 98 patients (10.8%) developed a second primary oral squamous cell carcinoma. Patients with second primary tumors presented significantly (p < 0.001) better overall survival in dependence of the index tumor compared to patients suffering from local recurrences. There was no significant difference in overall survival (p = 0.4) in dependence of the date of second primary tumor or local recurrence. Patients with second primary tumors were more likely to receive surgery-based therapy compared to patients with local recurrences who more frequently received definitive radiotherapy.

Conclusion

Our data indicates different clinical courses in terms of therapy and survival of patients suffering from second primary tumors compared to patients with local tumor recurrences. This may be due to a more aggressive biology of local recurrences and earlier detection of second primaries due to oncological follow-up of the index tumor.

Clinical relevance

The differentiation of local tumor recurrences and second primary tumors is of clinical relevance, as applicable therapies and resulting prognosis may differ significantly.
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Metadata
Title
Second primary squamous cell carcinoma of the oral cavity – a retrospective cohort study of therapeutic procedures and oncological outcome
Authors
Julius Moratin
Theresa Maas
Dominik Horn
Karl Semmelmayer
Sven Zittel
Marcel Oehme
Michael Engel
Jürgen Hoffmann
Christian Freudlsperger
Kolja Freier
Oliver Ristow
Publication date
01-04-2024
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 4/2024
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-024-05606-5

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