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Journal of Medical Case Reports

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Open Access 01-12-2024 | Complex Regional Pain Syndrome | Case report

Teriparatide and clodronate combination as a potential treatment for complex regional pain syndrome type I in delayed consolidation after foot surgery: a case report and review of the literature

Authors: F. Di Sacco, D. Antognetti, G. Ciapini, M. Nicastro, M. Scaglione, V. Bottai

Published in: Journal of Medical Case Reports | Issue 1/2024

Abstract

Background

Complex regional pain syndrome type I is a pathological condition characterized by an exaggerated response of tissues to low or moderate pain stimuli. The exact pathogenesis and optimal medical treatment for complex regional pain syndrome type I are still not fully understood, although bisphosphonates have shown positive effects in reducing pain. Foot surgery can be complicated by the development of complex regional pain syndrome type I, leading to functional decline and difficulties in weight-bearing.

Case presentation

The authors present a clinical case involving complex regional pain syndrome type I that developed after surgical foot arthrodesis. The patient, a 42-year-old Caucasian male, did not respond to clodronate treatment but experienced successful outcomes upon the addition of teriparatide, which effectively stimulated the healing of arthrodesis.

Conclusion

Teriparatide cannot be considered the primary treatment for complex regional pain syndrome due to insufficient solid clinical data. However, when complex regional pain syndrome is associated with or caused by delayed union, teriparatide can be used to address the underlying cause of complex regional pain syndrome.

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Title: Teriparatide and clodronate combination as a potential treatment for complex regional pain syndrome type I in delayed consolidation after foot surgery: a case report and review of the literature
Authors: F. Di Sacco
D. Antognetti
G. Ciapini
M. Nicastro
M. Scaglione
V. Bottai
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Complex Regional Pain Syndrome
Complex Regional Pain Syndrome
Foot Surgery
Bisphosphonate
Published in: Journal of Medical Case Reports / Issue 1/2024
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-024-04391-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Teriparatide and clodronate combination as a potential treatment for complex regional pain syndrome type I in delayed consolidation after foot surgery: a case report and review of the literature

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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