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Clinical Oral Investigations

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01-01-2024 | Laser | Research

The prophylactic effect of photobiomodulation therapy on pain perception due to infiltration injection: a randomized clinical trial

Authors: Shakiba Zandi, Hamid Sarlak, Malihe Safari, Ehsan Momeni

Published in: Clinical Oral Investigations | Issue 1/2024

Abstract

Objectives

Fear of pain in dentistry especially the injection involved in most of the processes has always been an important issue preventing the patients from consulting a dentist at the right time. This study aims to evaluate the effect of photobiomodulation therapy on reduction of pain in infiltration injection.

Materials and methods

This trial is a crossover study including 30 patients. The patients are divided into two groups (laser therapy in the first period and placebo effect in the next period or vice versa with split-mouth design) using the covariate adaptive randomization method. All the patients received bilateral maxillary canine anesthesia in two periods performed with an ICT injection device (amount of anesthesia solution loaded: 1.8 mL) at a speed of 1 mL/min and a temperature of the solution of 37 °C. In each period, patients received either a prophylactic dose of 940-nm laser (500 mW, 10 J/cm²) or its placebo effect before the injection. The degree of pain perception after each sort of treatment is evaluated by both SEM (Sound, Eye, Motor, and Pain) and VAS (Visual Analogue Scale) scales.

Results

According to analysis, all the patients scored a VAS scale under 3 in the period they received intervention. Also considering the SEM scale, most of the patients scored 0 in the intervention period. No adverse effect was reported during or after the process.

Conclusions

The study showed a significant effect of photobiomodulation on reducing pain perception during infiltration injection.

Clinical relevance

This method can be useful in order to lower the pain for the patients consulting a dentist and therefore facilitate consulting at early stages of the dental issues.

Trial registration

The registration number (date) of the clinical trial in a Primary Registry in the WHO Registry Network is IR.ARAKMU.REC.1398.248(13/03/2020). The related URL is https://en.irct.ir/trial/45362.

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Cohen S, Fiske J, Newton J (2000) The impact of dental anxiety on daily living. Br Dent J 189(7):385–390CrossRefPubMed

Sixou JL et al (2009) Pain assessment by children and adolescents during intraosseous anaesthesia using a computerized system (QuickSleeper™). Int J Paediatr Dent 19(5):360–366CrossRefPubMed

Palm A, Kirkegaard U, Poulsen S (2004) The wand versus traditional injection for mandibular nerve block in children and adolescents: perceived pain and time of onset. Pediatr Dent 26(6):481–484PubMed

Kaufman E et al (2005) A survey of pain, pressure, and discomfort induced by commonly used oral local anesthesia injections. Anesth Prog 52(4):122–127CrossRefPubMedPubMedCentral

Kuscu OO, Akyuz S (2008) Is it the injection device or the anxiety experienced that causes pain during dental local anaesthesia? Int J Pediatr Dent 18(2):139–145CrossRef

Aminabadi NA, Farahani RMZ (2009) The effect of pre-cooling the injection site on pediatric pain perception during the administration of local anesthesia. J Contemp Dent Pract 10(3):1–9CrossRef

Akhavan O, Ghaderi E (2013) Graphene nanomesh promises extremely efficient in vivo photothermal therapy. Small 9(21):3593–3601CrossRefPubMed

Keating A (2012) Mesenchymal stromal cells: new directions. Cell Stem Cell 10(6):709–716CrossRefPubMed

Ursell PG, Spalton DJ (1996) The effect of solution temperature on the pain of penbulbar anesthesia. Ophthalmology 103(5):839–841CrossRefPubMed

10.

Ghaderi F et al (2016) Pain management during needle insertion with low level laser. Eur J Paediatr Dent 17(1):151–154PubMed

11.

Favejee M, Huisstede B, Koes B (2011) Frozen shoulder: the effectiveness of conservative and surgical interventions—systematic review. Br J Sports Med 45(1):49–56CrossRefPubMed

12.

Palacios-Callender M et al (2004) Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci 101(20):7630–7635CrossRefPubMedPubMedCentralADS

13.

Bjordal JM et al (2008) A systematic review with procedural assessments and meta-analysis of low level laser therapy in lateral elbow tendinopathy (tennis elbow). BMC Musculoskelet Disord 9(1):1–15CrossRef

14.

Jackson RF, Roche G, Mangione T (2009) Low-level laser therapy effectiveness for reducing pain after breast augmentation. Am J Cosmet Surg 26(3):144–148CrossRef

15.

Moore KC et al (1992) The effect of infra-red diode laser irradiation on the duration and severity of postoperative pain: a double blind trial. Laser Ther 4(4):145–149CrossRefADS

16.

Khalighi HR, Mojahedi M, Parandoosh A (2021) Efficacy of Er, Cr: YSGG laser–assisted delivery of topical anesthesia in the oral mucosa. Clin Oral Invest 25(3):1055–1058CrossRef

17.

Jagtap B et al (2019) Painless injections–a possibility with low level laser therapy. J Dent Anesth Pain Med 19(3):159–165CrossRefPubMedPubMedCentral

18.

Suresh K (2011) An overview of randomization techniques: an unbiased assessment of outcome in clinical research. J Human Reprod Sci 4(1):8CrossRef

19.

Kalish LA, Begg CB (1985) Treatment allocation methods in clinical trials: a review. Stat Med 4(2):129–144CrossRefPubMed

20.

Bjordal JM et al (2006) Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Ther 24(2):158–168CrossRef

21.

Afkhami F, Ebrahimi H, Aghazadeh A, Sooratgar A, Chiniforush N (2022) Evaluation of the effect of the photobiomodulation therapy on the pain related to dental injections: a preliminary clinical trial. Dent Med Probl 59(3):421–425CrossRefPubMed

22.

Winder CB, LeBlanc SJ, Haley DB, Lissemore KD, Godkin MA, Duffield TF (2017) Clinical trial of local anesthetic protocols for acute pain associated with caustic paste disbudding in dairy calves. J Dairy Sci 100:6429–6441. https://doi.org/10.3168/jds.2017-12724CrossRefPubMed

23.

Sadeghi M, Sarlak H, Nakhostin A, Almasi-Hashiani A (2023) Which audio distraction technique is more effective for reduction the pain and anxiety of pediatric dental patients; “music” or “kids-story”? A randomized split-mouth crossover clinical trial. J Psychosom Res 168:111218. https://doi.org/10.1016/j.jpsychores.2023.111218CrossRefPubMed

24.

Li J-X (2013) The application of conditioning paradigms in the measurement of pain. Eur J Pharmacol 716:158–168. https://doi.org/10.1016/j.ejphar.2013.03.002CrossRefPubMedPubMedCentral

25.

Weary DM, Droege P, Braithwaite VA (2017) Behavioral evidence of felt emotions: approaches, inferences, and refinements. In Advances in the study of behavior, vol. 49 (eds Naguib M, Podos J, Simmons LW, Barrett L, Healy SD, Zuk M), pp. 27–48. New York, NY: Academic Press; See http://www.sciencedirect.com/science/article/pii/S0065345417300037

26.

Nesioonpour S et al (2014) Does low-level laser therapy enhance the efficacy of intravenous regional anesthesia? Pain Res Manage 19(6):e154–e158CrossRef

27.

Hegedűs B et al (2009) The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial. Photomed Laser Surg 27(4):577–584CrossRefPubMedPubMedCentral

28.

Ribeiro AS et al (2011) 660 AsGaAl laser to alleviate pain caused by cryosurgical treatment of oral leukoplakia: a preliminary study. Photomed Laser Surg 29(5):345–350CrossRefPubMed

29.

Lievens P (1991) The effect of a combined HeNe and IR laser treatment on the regeneration of the lymphatic system during the process of wound healing. Lasers Med Sci 6(2):193–199CrossRef

30.

AlGhamdi KM, Kumar A, Moussa NA (2012) Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells. Lasers Med Sci 27(1):237–249CrossRefPubMed

31.

Ghabraei S et al (2020) Effect of photobiomodulation on pain level during local anesthesia injection: a randomized clinical trial. J Cosmet Laser Ther 22(4–5):180–184CrossRefPubMed

32.

Li T et al (2015) Design, analysis, and reporting of crossover trials for inclusion in a meta-analysis. PLoS One 10(8):e0133023CrossRefPubMedPubMedCentral

33.

Seraj B et al (2023) Effect of photobiomodulation therapy with an 810-nm diode laser on pain perception associated with dental Injections in children: a double-blind randomized controlled clinical trial. J Lasers Med Sci 14:e19CrossRefPubMedPubMedCentral

34.

Sattayut S (2014) Low intensity laser for reducing pain from anesthetic palatal injection. Photomed Laser Surg 32(12):658–662CrossRefPubMed

35.

Dehgan D, Şermet Elbay Ü, Elbay M (2022) Evaluation of the effects of photobiomodulation with different laser application doses on injection pain in children: a randomized clinical trial. Lasers Med Sci 38(1):6CrossRefPubMed

36.

Kermanshah H, Chiniforush N, Kolahdouz Mohammadi M, Motevasselian F (2022) Effect of photobiomodulation therapy with 915 nm diode laser on pain perception during local anesthesia of maxillary incisors: a randomized controlled trial. Photochem Photobiol 98(6):1471–1475CrossRefPubMed

Title: The prophylactic effect of photobiomodulation therapy on pain perception due to infiltration injection: a randomized clinical trial
Authors: Shakiba Zandi
Hamid Sarlak
Malihe Safari
Ehsan Momeni
Publication date: 01-01-2024
Publisher: Springer Berlin Heidelberg
Keyword: Laser
Published in: Clinical Oral Investigations / Issue 1/2024
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05394-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The prophylactic effect of photobiomodulation therapy on pain perception due to infiltration injection: a randomized clinical trial

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Trial registration

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