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Open Access 01-12-2013 | Short report

Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report

Authors: Alessandro Borghi, Elisabetta Caselli, Dario Di Luca, Adolfo Sebastiani, Paolo Perri, Silva Seraceni, Carlo Contini, Annarosa Virgili

Published in: Infectious Agents and Cancer | Issue 1/2013

Abstract

Background

The etiology of primary cutaneous anaplastic large-cell CD30+ lymphoma is largely unknown, and although an infectious involvement has been suspected, the implication of infectious agents in its pathogenesis is still unclear.

Findings

We report the case of a HIV-negative patient referred to our hospital with a rapidly enlarging skin tumor on her upper eyelid. Surgical excision was performed and histological analysis evidenced a primary cutaneous anaplastic large-cell lymphoma. Due to the ocular localization and to the prominent angiogenic component of the lesion, molecular analyses for the detection of Chlamydophila pneumonia e and HHV8 were performed, revealing the presence of an infection by both pathogens in surgical biopsy and in peripheral blood mononuclear cells.

Conclusions

These findings suggest for the first time a possible association of C. pneumoniae and/or HHV8 infection, or both together, with primary cutaneous anaplastic large-cell lymphoma in non-immunocompromised and HIV-negative subjects. This potential pathogenic association, if confirmed, could provide potential indications for future therapy.

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Title: Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report
Authors: Alessandro Borghi
Elisabetta Caselli
Dario Di Luca
Adolfo Sebastiani
Paolo Perri
Silva Seraceni
Carlo Contini
Annarosa Virgili
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Infectious Agents and Cancer / Issue 1/2013
Electronic ISSN: 1750-9378
DOI: https://doi.org/10.1186/1750-9378-8-41

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