Onychomycosis Caused by Fusarium Species: a Review

go back to reference Lipner SR, Scher RK. Part I: onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80(4):835–51. https://doi.org/10.1016/j.jaad.2018.03.062.CrossRefPubMed Lipner SR, Scher RK. Part I: onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80(4):835–51. https://​doi.​org/​10.​1016/​j.​jaad.​2018.​03.​062.CrossRefPubMed

go back to reference Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, Piraccini BM. Onychomycosis: a review. J Eur Acad Dermatol Venereol. 2020;34(9):1972–90. https://doi.org/10.1111/jdv.16394.CrossRefPubMed Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, Piraccini BM. Onychomycosis: a review. J Eur Acad Dermatol Venereol. 2020;34(9):1972–90. https://​doi.​org/​10.​1111/​jdv.​16394.CrossRefPubMed

go back to reference Uriarte-Mayorga DF, Gómez-González BA, Armenta-Ramos JS, et al. Onicomicosis por Fusarium Sp.: una entidad clínica rara A propósito de un caso. Med Cutan Iber Lat Am. 2018;46(2):142–5. Uriarte-Mayorga DF, Gómez-González BA, Armenta-Ramos JS, et al. Onicomicosis por Fusarium Sp.: una entidad clínica rara A propósito de un caso. Med Cutan Iber Lat Am. 2018;46(2):142–5.

go back to reference Ranawaka RR, Nagahawatte A, Gunasekara TA. Fusarium onychomycosis: prevalence, clinical presentations, response to itraconazole and terbinafine pulse therapy, and 1-year follow-up in nine cases. Int J Dermatol. 2015;54(11):1275–82. https://doi.org/10.1111/ijd.12906.CrossRefPubMed Ranawaka RR, Nagahawatte A, Gunasekara TA. Fusarium onychomycosis: prevalence, clinical presentations, response to itraconazole and terbinafine pulse therapy, and 1-year follow-up in nine cases. Int J Dermatol. 2015;54(11):1275–82. https://​doi.​org/​10.​1111/​ijd.​12906.CrossRefPubMed

go back to reference Uemura EVG, Barbosa MDS, Simionatto S, Al-Harrasi A, Al-Hatmi AMS, Rossato L. Onychomycosis caused by Fusarium species. J Fungi (Basel). 2022;8(4):360. https://doi.org/10.3390/jof8040360.CrossRefPubMed Uemura EVG, Barbosa MDS, Simionatto S, Al-Harrasi A, Al-Hatmi AMS, Rossato L. Onychomycosis caused by Fusarium species. J Fungi (Basel). 2022;8(4):360. https://​doi.​org/​10.​3390/​jof8040360.CrossRefPubMed

go back to reference Araiza J, Saldaña M, Dávila I, Tirado-Sánchez A. Onicomicosis por Fusarium spp en pacientes con neoplasias hematológicas. Dermatol Rev Mex. 2020;64(4):371–8. Araiza J, Saldaña M, Dávila I, Tirado-Sánchez A. Onicomicosis por Fusarium spp en pacientes con neoplasias hematológicas. Dermatol Rev Mex. 2020;64(4):371–8.

go back to reference Phaitoonwattanakij S, Leeyaphan C, Lertrujiwanit K, Bunyaratavej S. Predisposing factors, clinical features and treatment outcomes of Fusarium onychomycosis and comparison of its characteristics with Neoscytalidium onychomycosis. J Mycol Med. 2021;31(3):101165. https://doi.org/10.1016/j.mycmed.2021.CrossRefPubMed Phaitoonwattanakij S, Leeyaphan C, Lertrujiwanit K, Bunyaratavej S. Predisposing factors, clinical features and treatment outcomes of Fusarium onychomycosis and comparison of its characteristics with Neoscytalidium onychomycosis. J Mycol Med. 2021;31(3):101165. https://​doi.​org/​10.​1016/​j.​mycmed.​2021.CrossRefPubMed

go back to reference Nucci M, Barreiros G, Akiti T, Anaissie E, Nouér SA. Invasive fusariosis in patients with hematologic diseases. J Fungi (Basel). 2021;7(10):815. https://doi.org/10.3390/jof7100815.CrossRefPubMed Nucci M, Barreiros G, Akiti T, Anaissie E, Nouér SA. Invasive fusariosis in patients with hematologic diseases. J Fungi (Basel). 2021;7(10):815. https://​doi.​org/​10.​3390/​jof7100815.CrossRefPubMed

go back to reference Castro López N, Casas C, Sopo L, Rojas A, Del Portillo P, Cepero de García MC, Restrepo S. Fusarium species detected in onychomycosis in Colombia. Mycoses. 2009;52(4):350–6. https://doi.org/10.1111/j.1439-0507.2008.01619.x.CrossRefPubMed Castro López N, Casas C, Sopo L, Rojas A, Del Portillo P, Cepero de García MC, Restrepo S. Fusarium species detected in onychomycosis in Colombia. Mycoses. 2009;52(4):350–6. https://​doi.​org/​10.​1111/​j.​1439-0507.​2008.​01619.​x.CrossRefPubMed

go back to reference Varon AG, Nouer SA, Barreiros G, Trope BM, Magalhães F, Akiti T, Garnica M, Nucci M. Superficial skin lesions positive for Fusarium are associated with subsequent development of invasive fusariosis. J Infect. 2014;68(1):85–9. https://doi.org/10.1016/j.jinf.2013.08.011.CrossRefPubMed Varon AG, Nouer SA, Barreiros G, Trope BM, Magalhães F, Akiti T, Garnica M, Nucci M. Superficial skin lesions positive for Fusarium are associated with subsequent development of invasive fusariosis. J Infect. 2014;68(1):85–9. https://​doi.​org/​10.​1016/​j.​jinf.​2013.​08.​011.CrossRefPubMed

go back to reference Estrada VFM, González AZ, Lugo FP. Onicomicosis por Fusarium chlamydosporum en un paciente diabético Reporte de caso y revisión de la literatura. Dermatología Cosmética, Médica y Quirúrgica. 2022;20(1):33–6. Estrada VFM, González AZ, Lugo FP. Onicomicosis por Fusarium chlamydosporum en un paciente diabético Reporte de caso y revisión de la literatura. Dermatología Cosmética, Médica y Quirúrgica. 2022;20(1):33–6.

go back to reference Sequeira-Oviedo PM, Lozada-Alvarado S, Salas-Campos I, Jaikel-Víquez D. Susceptibilidad antimicrobiana de los aislamientos de Fusarium solani provenientes de onicomicosis. Dermatol Rev Mex. 2017;61(3):197–205. Sequeira-Oviedo PM, Lozada-Alvarado S, Salas-Campos I, Jaikel-Víquez D. Susceptibilidad antimicrobiana de los aislamientos de Fusarium solani provenientes de onicomicosis. Dermatol Rev Mex. 2017;61(3):197–205.

go back to reference Tupaki-Sreepurna A, Kindo AJ. Fusarium: the versatile pathogen. Indian J Med Microbiol. 2018;36(1):8–17. https://doi.org/10.4103/ijmm.IJMM_16_24.CrossRefPubMed Tupaki-Sreepurna A, Kindo AJ. Fusarium: the versatile pathogen. Indian J Med Microbiol. 2018;36(1):8–17. https://​doi.​org/​10.​4103/​ijmm.​IJMM_​16_​24.CrossRefPubMed

go back to reference Van Diepeningen AD, Al-Hatmi AMS, Brankovics B, et al. Taxonomy and clinical spectra of Fusarium species: where do we stand in 2014? Curr Clin Micro Rpt. 2014;1:10–8. https://doi.org/10.1007/s40588-014-0003-x.CrossRef Van Diepeningen AD, Al-Hatmi AMS, Brankovics B, et al. Taxonomy and clinical spectra of Fusarium species: where do we stand in 2014? Curr Clin Micro Rpt. 2014;1:10–8. https://​doi.​org/​10.​1007/​s40588-014-0003-x.CrossRef

go back to reference • Eiga FF, de Castro-Hoshino LV, Sato F, Baesso ML, Silva S, Negri M, Svidzinski TIE. Characterization of a biofilm formed by Fusarium oxysporum on the human nails. Int J Dermatol. 2022;61(2):191–8. https://doi.org/10.1111/ijd.15747. This study clarifies the fusarial pathogenesis and invasion process.CrossRef • Eiga FF, de Castro-Hoshino LV, Sato F, Baesso ML, Silva S, Negri M, Svidzinski TIE. Characterization of a biofilm formed by Fusarium oxysporum on the human nails. Int J Dermatol. 2022;61(2):191–8. https://​doi.​org/​10.​1111/​ijd.​15747. This study clarifies the fusarial pathogenesis and invasion process.CrossRef

go back to reference Machado Vila TV, Sousa Quintanilha N, Rozental S. Miltefosine is effective against Candida albicans and Fusarium oxysporum nail biofilms in vitro. J Med Microbiol. 2015;64:1436–49. https://doi.org/10.1099/jmm.0.000175.CrossRefPubMed Machado Vila TV, Sousa Quintanilha N, Rozental S. Miltefosine is effective against Candida albicans and Fusarium oxysporum nail biofilms in vitro. J Med Microbiol. 2015;64:1436–49. https://​doi.​org/​10.​1099/​jmm.​0.​000175.CrossRefPubMed

go back to reference Ngo TMC, Nu PAT, Cao LC, Ha TNT, Do TBT, Thi GT. A case of onychomycosis caused by a terbinafine-susceptible Fusarium solani in Vietnam. Iran J Microbiol. 2022;14(6):932–6. https://doi.org/10.18502/ijm.v14i6.11269.CrossRefPubMedPubMedCentral Ngo TMC, Nu PAT, Cao LC, Ha TNT, Do TBT, Thi GT. A case of onychomycosis caused by a terbinafine-susceptible Fusarium solani in Vietnam. Iran J Microbiol. 2022;14(6):932–6. https://​doi.​org/​10.​18502/​ijm.​v14i6.​11269.CrossRefPubMedPubMedCentral

go back to reference Gupta AK, Venkataraman M, Renaud HJ, Summerbell R, Shear NH, Piguet V. A paradigm shift in the treatment and management of onychomycosis. Skin Appendage Disord. 2021;7(5):351–8. https://doi.org/10.1159/000516112.CrossRefPubMedPubMedCentral Gupta AK, Venkataraman M, Renaud HJ, Summerbell R, Shear NH, Piguet V. A paradigm shift in the treatment and management of onychomycosis. Skin Appendage Disord. 2021;7(5):351–8. https://​doi.​org/​10.​1159/​000516112.CrossRefPubMedPubMedCentral

go back to reference Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA. Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. Lancet Infect Dis. 2021;21(8):e246-e257. https://doi.org/10.1016/S1473-3099(20)30784-2. Erratum in: Lancet Infect Dis. 21(4):e81. Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA. Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. Lancet Infect Dis. 2021;21(8):e246-e257. https://​doi.​org/​10.​1016/​S1473-3099(20)30784-2. Erratum in: Lancet Infect Dis. 21(4):e81.

go back to reference Lecerf P, Abdy S, Vollono L, Pastushenko I, Richert B, André J. Direct examination, histopathology and fungal culture for the diagnosis of onychomycosis: a retrospective, comparative study on 2245 specimens. Mycoses. 2021;64(2):187–93. https://doi.org/10.1111/myc.13201.CrossRefPubMed Lecerf P, Abdy S, Vollono L, Pastushenko I, Richert B, André J. Direct examination, histopathology and fungal culture for the diagnosis of onychomycosis: a retrospective, comparative study on 2245 specimens. Mycoses. 2021;64(2):187–93. https://​doi.​org/​10.​1111/​myc.​13201.CrossRefPubMed

go back to reference Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Ihn H. Non-dermatophyte mould onychomycosis in Japan. Med Mycol J. 2020;61(2):23–31. https://doi.org/10.3314/mmj.20-00007.CrossRefPubMed Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Ihn H. Non-dermatophyte mould onychomycosis in Japan. Med Mycol J. 2020;61(2):23–31. https://​doi.​org/​10.​3314/​mmj.​20-00007.CrossRefPubMed

go back to reference Bassiri-Jahromi S, Khaksar AA. Nondermatophytic moulds as a causative agent of onychomycosis in Tehran. Indian J Dermatol. 2010;55(2):140–3. https://doi.org/10.4103/0019-5154.62743.CrossRefPubMedPubMedCentral Bassiri-Jahromi S, Khaksar AA. Nondermatophytic moulds as a causative agent of onychomycosis in Tehran. Indian J Dermatol. 2010;55(2):140–3. https://​doi.​org/​10.​4103/​0019-5154.​62743.CrossRefPubMedPubMedCentral

go back to reference •• Litaiem N, Mnif E, Zeglaoui F. Dermoscopy of onychomycosis: a systematic review. Dermatol Pract Concept. 2023;13(1):e2023072. https://doi.org/10.5826/dpc.1301a72. This review provides a unifying terminology to describe dermoscopic signs of onychomycosis.CrossRefPubMedPubMedCentral •• Litaiem N, Mnif E, Zeglaoui F. Dermoscopy of onychomycosis: a systematic review. Dermatol Pract Concept. 2023;13(1):e2023072. https://​doi.​org/​10.​5826/​dpc.​1301a72. This review provides a unifying terminology to describe dermoscopic signs of onychomycosis.CrossRefPubMedPubMedCentral

go back to reference Liu X, Yao Z-Y. Advance in application of dermoscopy for onychomycosis diagnosis. Int J Dermatol Venereol. 2019;2(1):19. Liu X, Yao Z-Y. Advance in application of dermoscopy for onychomycosis diagnosis. Int J Dermatol Venereol. 2019;2(1):19.

go back to reference Falotico JM, Lipner SR. Updated perspectives on the diagnosis and management of onychomycosis. Clin Cosmet Investig Dermatol. 2022;15(15):1933–57. https://doi.org/10.3760/cma.j.issn.2096-5540.2019.01.004.CrossRefPubMedPubMedCentral Falotico JM, Lipner SR. Updated perspectives on the diagnosis and management of onychomycosis. Clin Cosmet Investig Dermatol. 2022;15(15):1933–57. https://​doi.​org/​10.​3760/​cma.​j.​issn.​2096-5540.​2019.​01.​004.CrossRefPubMedPubMedCentral

go back to reference Barzilai A, Greenbaum H, Huszar M, Ikher S, Shemer A, Baum S. the role of histological examination of nail clipping in the diagnosis of onychomycosis. Isr Med Assoc J. 2023;25(2):117–21.PubMed Barzilai A, Greenbaum H, Huszar M, Ikher S, Shemer A, Baum S. the role of histological examination of nail clipping in the diagnosis of onychomycosis. Isr Med Assoc J. 2023;25(2):117–21.PubMed

go back to reference AvkanOguz V, Karabicak N, Irmak C, Unek T. Fusarium solani species complex infection treated with posaconazole in a liver transplantation patient; a case report. J Mycol Med. 2023;33(3):101382. https://doi.org/10.1016/j.mycmed.2023.101382.CrossRef AvkanOguz V, Karabicak N, Irmak C, Unek T. Fusarium solani species complex infection treated with posaconazole in a liver transplantation patient; a case report. J Mycol Med. 2023;33(3):101382. https://​doi.​org/​10.​1016/​j.​mycmed.​2023.​101382.CrossRef

go back to reference Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35(8):909–20. https://doi.org/10.1086/342328.CrossRefPubMed Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35(8):909–20. https://​doi.​org/​10.​1086/​342328.CrossRefPubMed

go back to reference Hof H. The medical relevance of Fusarium spp. J Fungi (Basel). 2020;6(3):117. https://doi.org/10.3390/jof6030117.CrossRefPubMed Hof H. The medical relevance of Fusarium spp. J Fungi (Basel). 2020;6(3):117. https://​doi.​org/​10.​3390/​jof6030117.CrossRefPubMed