Skip to main content
Top
Published in: Environmental Health and Preventive Medicine 4/2016

01-07-2016 | Regular Article

Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China

Authors: Zheng Liu, Xiang-Dong Li, Bo-Hui Guo, Yi Li, Ming Zhao, Hai-Yan Shen, Ying Zhai, Xue-Li Wang, Tao Liu

Published in: Environmental Health and Preventive Medicine | Issue 4/2016

Login to get access

Abstract

Objectives

During July to October 2013, the Asian giant hornet has killed 42 and injured 1,675 people in the southern part of Shaanxi Province, China. This study investigated this unusual and frequent public health event.

Methods

During the 3 months, 103 patients with severe Asian hornet stings were hospitalized in our hospital. Clinical data were collected using a standardized data collection form which included sex, age, length of hospital stay and medical recorder.

Results

After physical examination and laboratory investigation, 25.2, 46.6 and 44.7 % of the patients were found with varying degrees of acute interstitial nephritis, acute toxic hepatitis and acute toxic myocarditis, respectively. After timely and appropriate treatment including removal of the stings and the use of intravenous methylprednisolone and antihistamines, the kidney function, liver function and heart function of 99 patients recovered within 1 month, while four patients died.

Conclusions

This study provided a good opportunity for recognizing the effect of Asian giant hornet stings and evaluating this serious public health event.
Literature
1.
go back to reference Shackelford G, Steward PR, Benton TG, Kunin WE, Potts SG, Biesmeijer JC, et al. Comparison of pollinators and natural enemies: a meta-analysis of landscape and local effects on abundance and richness in crops. Biol Rev Camb Philos Soc. 2013;88(4):1002–21.CrossRefPubMed Shackelford G, Steward PR, Benton TG, Kunin WE, Potts SG, Biesmeijer JC, et al. Comparison of pollinators and natural enemies: a meta-analysis of landscape and local effects on abundance and richness in crops. Biol Rev Camb Philos Soc. 2013;88(4):1002–21.CrossRefPubMed
2.
go back to reference Kergunteuil A, Basso C, Pintureau B. Impact of two ant species on egg parasitoids released as part of a biological control program. J Insect Sci. 2013;13:106.CrossRefPubMedPubMedCentral Kergunteuil A, Basso C, Pintureau B. Impact of two ant species on egg parasitoids released as part of a biological control program. J Insect Sci. 2013;13:106.CrossRefPubMedPubMedCentral
3.
go back to reference Zoltán V. First records of three ichneumon wasp species in Hungary (Hymenoptera: Ichneumonidae). Folia entomologica hungarica. 2013;74:189–94. Zoltán V. First records of three ichneumon wasp species in Hungary (Hymenoptera: Ichneumonidae). Folia entomologica hungarica. 2013;74:189–94.
4.
go back to reference Villemant C, Zuccon D, Rome Q, Muller F, Poinar GO, Justine JL. Can parasites halt the invader? Mermithid nematodes parasitizing the yellow-legged Asian hornet in France. PeerJ. 2015;3:e947.CrossRefPubMedPubMedCentral Villemant C, Zuccon D, Rome Q, Muller F, Poinar GO, Justine JL. Can parasites halt the invader? Mermithid nematodes parasitizing the yellow-legged Asian hornet in France. PeerJ. 2015;3:e947.CrossRefPubMedPubMedCentral
5.
go back to reference Yanagawa Y, Morita K, Sugiura T, Okada Y. Cutaneous hemorrhage or necrosis findings after Vespa mandarinia (wasp) stings may predict the occurrence of multiple organ injury: a case report and review of literature. Clin Toxicol. 2007;45(7):803–7.CrossRef Yanagawa Y, Morita K, Sugiura T, Okada Y. Cutaneous hemorrhage or necrosis findings after Vespa mandarinia (wasp) stings may predict the occurrence of multiple organ injury: a case report and review of literature. Clin Toxicol. 2007;45(7):803–7.CrossRef
6.
go back to reference Vachvanichsanong P, Dissaneewate P. Acute renal failure following wasp sting in children. Eur J Pediatr. 2009;168(8):991–4.CrossRefPubMed Vachvanichsanong P, Dissaneewate P. Acute renal failure following wasp sting in children. Eur J Pediatr. 2009;168(8):991–4.CrossRefPubMed
7.
go back to reference Haro L, Labadie M, Chanseau P, Cabot C, Blanc-Brisset I, Penouil F. Medical consequences of the Asian black hornet (Vespa velutina) invasion in Southwestern France. Toxicon. 2010;55(2–3):650–2.CrossRefPubMed Haro L, Labadie M, Chanseau P, Cabot C, Blanc-Brisset I, Penouil F. Medical consequences of the Asian black hornet (Vespa velutina) invasion in Southwestern France. Toxicon. 2010;55(2–3):650–2.CrossRefPubMed
8.
go back to reference McGain F, Harrison J, Winkel KD. Wasp sting mortality in Australia. Med J Aust. 2000;173(4):198–200.PubMed McGain F, Harrison J, Winkel KD. Wasp sting mortality in Australia. Med J Aust. 2000;173(4):198–200.PubMed
9.
go back to reference Thiruventhiran T, Goh BL, Leong CL, Cheah PL, Looi LM, Tan SY. Acute renal failure following multiple wasp stings. Nephrol Dial Transplant. 1999;14(1):214–7.CrossRefPubMed Thiruventhiran T, Goh BL, Leong CL, Cheah PL, Looi LM, Tan SY. Acute renal failure following multiple wasp stings. Nephrol Dial Transplant. 1999;14(1):214–7.CrossRefPubMed
10.
go back to reference Xie C, Xu S, Ding F, Xie M, Lv J, Yao J, et al. Clinical features of severe wasp sting patients with dominantly toxic reaction: analysis of 1091 cases. PLoS ONE. 2013;8(12):e83164.CrossRefPubMedPubMedCentral Xie C, Xu S, Ding F, Xie M, Lv J, Yao J, et al. Clinical features of severe wasp sting patients with dominantly toxic reaction: analysis of 1091 cases. PLoS ONE. 2013;8(12):e83164.CrossRefPubMedPubMedCentral
11.
go back to reference Sukprasert S, Rungsa P, Uawonggul N, Incamnoi P, Thammasirirak S, Daduang J, et al. Purification and structural characterisation of phospholipase A1 (Vespapase, Ves a 1) from Thai banded tiger wasp (Vespa affinis) venom. Toxicon. 2013;61:151–64.CrossRefPubMed Sukprasert S, Rungsa P, Uawonggul N, Incamnoi P, Thammasirirak S, Daduang J, et al. Purification and structural characterisation of phospholipase A1 (Vespapase, Ves a 1) from Thai banded tiger wasp (Vespa affinis) venom. Toxicon. 2013;61:151–64.CrossRefPubMed
12.
go back to reference King TP, Jim SY, Wittkowski KM. Inflammatory role of two venom components of yellow jackets (Vespula vulgaris): a mast cell degranulating peptide mastoparan and phospholipase A1. Int Arch Allergy Immunol. 2003;131(1):25–32.CrossRefPubMed King TP, Jim SY, Wittkowski KM. Inflammatory role of two venom components of yellow jackets (Vespula vulgaris): a mast cell degranulating peptide mastoparan and phospholipase A1. Int Arch Allergy Immunol. 2003;131(1):25–32.CrossRefPubMed
13.
go back to reference Moreno M, Giralt E. Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan. Toxins. 2015;7(4):1126–50.CrossRefPubMedPubMedCentral Moreno M, Giralt E. Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan. Toxins. 2015;7(4):1126–50.CrossRefPubMedPubMedCentral
14.
go back to reference Abe T, Kawai N, Niwa A. Purification and properties of a presynaptically acting neurotoxin, mandaratoxin, from hornet (Vespa mandarinia). Biochemistry. 1982;21(7):1693–7.CrossRefPubMed Abe T, Kawai N, Niwa A. Purification and properties of a presynaptically acting neurotoxin, mandaratoxin, from hornet (Vespa mandarinia). Biochemistry. 1982;21(7):1693–7.CrossRefPubMed
15.
go back to reference Grisotto LS, Mendes GE, Castro I, Baptista MA, Alves VA, Yu L, et al. Mechanisms of bee venom-induced acute renal failure. Toxicon. 2006;48(1):44–54.CrossRefPubMed Grisotto LS, Mendes GE, Castro I, Baptista MA, Alves VA, Yu L, et al. Mechanisms of bee venom-induced acute renal failure. Toxicon. 2006;48(1):44–54.CrossRefPubMed
16.
go back to reference Li XD, Liu Z, Zhai Y, Zhao M, Shen HY, Li Y, et al. Acute Interstitial Nephritis Following Multiple Asian Giant Hornet Stings. Am J Case Rep. 2015;16:371–3.CrossRefPubMedPubMedCentral Li XD, Liu Z, Zhai Y, Zhao M, Shen HY, Li Y, et al. Acute Interstitial Nephritis Following Multiple Asian Giant Hornet Stings. Am J Case Rep. 2015;16:371–3.CrossRefPubMedPubMedCentral
17.
go back to reference Desille M, Corcos L, L’Helgoualc’h A, Frémond B, Campion JP, Guillouzo A, et al. Detoxifying activity in pig livers and hepatocytes intended for xenotherapy. Transplantation. 1999;68(10):1437–43.CrossRefPubMed Desille M, Corcos L, L’Helgoualc’h A, Frémond B, Campion JP, Guillouzo A, et al. Detoxifying activity in pig livers and hepatocytes intended for xenotherapy. Transplantation. 1999;68(10):1437–43.CrossRefPubMed
18.
go back to reference Arrigo T, Leonardi S, Cuppari C, Manti S, Lanzafame A, D’Angelo G, et al. Role of the diet as a link between oxidative stress and liver diseases. World J Gastroenterol. 2015;21(2):384–95.CrossRefPubMedPubMedCentral Arrigo T, Leonardi S, Cuppari C, Manti S, Lanzafame A, D’Angelo G, et al. Role of the diet as a link between oxidative stress and liver diseases. World J Gastroenterol. 2015;21(2):384–95.CrossRefPubMedPubMedCentral
19.
go back to reference Neuman MG, Cotariu D, Eshchar J, Barr-Nea L, Ishay JS. Liver damage induced by Oriental hornet venom sac extract at the level of subcellular fractions. Clin Biochem. 1987;20(2):85–90.CrossRefPubMed Neuman MG, Cotariu D, Eshchar J, Barr-Nea L, Ishay JS. Liver damage induced by Oriental hornet venom sac extract at the level of subcellular fractions. Clin Biochem. 1987;20(2):85–90.CrossRefPubMed
20.
go back to reference Sakhuja V, Bhalla A, Pereira BJ, Kapoor MM, Bhusnurmath SR, Chugh KS. Acute renal failure following multiple hornet stings. Nephron. 1988;49(4):319–21.CrossRefPubMed Sakhuja V, Bhalla A, Pereira BJ, Kapoor MM, Bhusnurmath SR, Chugh KS. Acute renal failure following multiple hornet stings. Nephron. 1988;49(4):319–21.CrossRefPubMed
21.
go back to reference Tsai CL, Fang CC, Chen WJ, Dierberg K. Hornet sting-induced toxic hepatitis. Clin Toxicol. 2005;43(2):127–8.CrossRef Tsai CL, Fang CC, Chen WJ, Dierberg K. Hornet sting-induced toxic hepatitis. Clin Toxicol. 2005;43(2):127–8.CrossRef
22.
go back to reference Brasher GW, Sanchez SA. Reversible electrocardiographic changes associated with wasp sting anaphylaxis. JAMA. 1974;229(9):1210–1.CrossRefPubMed Brasher GW, Sanchez SA. Reversible electrocardiographic changes associated with wasp sting anaphylaxis. JAMA. 1974;229(9):1210–1.CrossRefPubMed
23.
go back to reference Levine HD. Acute myocardial infarction following wasp sting. Report of two cases and critical survey of the literature. Am Heart J. 1976;91(3):365–74.CrossRefPubMed Levine HD. Acute myocardial infarction following wasp sting. Report of two cases and critical survey of the literature. Am Heart J. 1976;91(3):365–74.CrossRefPubMed
24.
go back to reference Kularatne K, Kannangare T, Jayasena A, Jayasekera A, Waduge R, Weerakoon K, et al. Fatal acute pulmonary oedema and acute renal failure following multiple wasp/hornet (Vespa affinis) stings in Sri Lanka: two case reports. J Med Case Rep. 2014;8:188.CrossRefPubMedPubMedCentral Kularatne K, Kannangare T, Jayasena A, Jayasekera A, Waduge R, Weerakoon K, et al. Fatal acute pulmonary oedema and acute renal failure following multiple wasp/hornet (Vespa affinis) stings in Sri Lanka: two case reports. J Med Case Rep. 2014;8:188.CrossRefPubMedPubMedCentral
25.
go back to reference Cvetković-Matić D, Asanin M, Matić D, Ivanović B, Simić D, Kalezić N, et al. Acute myocardial infarction following a hornet sting. Vojnosanit Pregl. 2009;66(4):333–7.CrossRefPubMed Cvetković-Matić D, Asanin M, Matić D, Ivanović B, Simić D, Kalezić N, et al. Acute myocardial infarction following a hornet sting. Vojnosanit Pregl. 2009;66(4):333–7.CrossRefPubMed
26.
go back to reference Simon GB, Konrad EB, Robert JH. Insect sting anaphylaxis: prospective evaluation of treatment with intravenous adrenaline and volume resuscitation. Emerg Med J. 2004;21(2):149–54.CrossRef Simon GB, Konrad EB, Robert JH. Insect sting anaphylaxis: prospective evaluation of treatment with intravenous adrenaline and volume resuscitation. Emerg Med J. 2004;21(2):149–54.CrossRef
27.
go back to reference Goodman JW, Goldfarb DS. The Role of Continuous Renal Replacement Therapy in the Treatment of Poisoning. Semin Dial. 2006;19(5):402–7.CrossRefPubMed Goodman JW, Goldfarb DS. The Role of Continuous Renal Replacement Therapy in the Treatment of Poisoning. Semin Dial. 2006;19(5):402–7.CrossRefPubMed
Metadata
Title
Acute interstitial nephritis, toxic hepatitis and toxic myocarditis following multiple Asian giant hornet stings in Shaanxi Province, China
Authors
Zheng Liu
Xiang-Dong Li
Bo-Hui Guo
Yi Li
Ming Zhao
Hai-Yan Shen
Ying Zhai
Xue-Li Wang
Tao Liu
Publication date
01-07-2016
Publisher
Springer Japan
Published in
Environmental Health and Preventive Medicine / Issue 4/2016
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1007/s12199-016-0516-4

Other articles of this Issue 4/2016

Environmental Health and Preventive Medicine 4/2016 Go to the issue