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01-04-2012 | Original article

LINAC-radiosurgery for nonsecreting pituitary adenomas

Long-term results

Authors: M.J.R. Runge, MD, M. Maarouf, MD, S. Hunsche, M. Kocher, M.I. Ruge, F. El Majdoub, H. Treuer, R.-P. Mueller, J. Voges, Univ.-Prof. Dr. V. Sturm

Published in: Strahlentherapie und Onkologie | Issue 4/2012

Abstract

Background and purpose

Stereotactic linear accelerator-based radiosurgery (LINAC-RS) is increasingly used for microsurgically inaccessible or recurrent pituitary adenomas. This single-center study evaluates the long-term follow-up after LINAC-RS of nonsecreting pituitary adenomas (NSA).

Patients and methods

Between 1992 and August 2008, 65 patients with NSA were treated. Patient treatment and follow-up were conducted according to a prospective protocol. Indications for LINAC-RS were (1) tumor recurrence or (2) residual tumor. Three patients were treated primarily. For analysis of prognostic factors, patients were grouped according to epidemiological or treatment-associated characteristics.

Results

A total of 61 patients with a follow-up ≥ 12 months (median 83 months, range 15–186 months, longest follow-up of published radiosurgery series) were evaluated with regard to their clinical, radiological, and endocrinological course. The median tumor volume was 3.5 ml (± 4.3 ml, range 0.3–17.3 ml) treated with a median surface and maximum dose of 13.0 Gy and 29.7 Gy, respectively. Local tumor control was achieved in 98%. One patient died of unrelated cause after 36 months and 1 patient developed a radiation-induced seizure disorder. Visual complications did not occur. In 37 of 41 patients (90.2%), pituitary function remained stable. Maximum dose to the pituitary ≤ 16 Gy and female gender were positive prognostic factors for the preservation of pituitary function.

Conclusion

LINAC-RS is a minimally invasive, safe, and effective treatment for recurrent NSA or microsurgically inaccessible residual tumor. LINAC-RS yielded a high rate of local long-term tumor control with a small number of radiation-induced side effects.

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Title: LINAC-radiosurgery for nonsecreting pituitary adenomas
Long-term results
Authors: M.J.R. Runge, MD
M. Maarouf, MD
S. Hunsche
M. Kocher
M.I. Ruge
F. El Majdoub
H. Treuer
R.-P. Mueller
J. Voges
Univ.-Prof. Dr. V. Sturm
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Strahlentherapie und Onkologie / Issue 4/2012
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-011-0052-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

LINAC-radiosurgery for nonsecreting pituitary adenomas

Long-term results

Abstract

Background and purpose

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and purpose

Patients and methods

Results

Conclusion

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