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Published in:

01-05-2010

LigaSure for Pancreatic Sealing During Distal Pancreatectomy

Authors: Werner Hartwig, Martin Duckheim, Oliver Strobel, Dmitry Dovzhanskiy, Frank Bergmann, Thilo Hackert, Markus W. Büchler, Jens Werner

Published in: World Journal of Surgery | Issue 5/2010

Abstract

Background

Pancreatic fistula is an unresolved problem after distal pancreatectomy. The current study investigated the safety of LigaSure for distal pancreatic resection in a porcine model.

Methods

A distal pancreatectomy was performed in 22 pigs. Animals were randomly assigned to undergo conventional scalpel transection with hand-sewn closure of the pancreatic remnant or pancreatic transection and sealing by LigaSure. Closed-suction drainage was collected daily. Animals were sacrificed on postoperative day (POD) 7 and the pancreatic remnant was sampled for histology.

Results

Two grade A postoperative temporary pancreatic fistulas (ISGPF definition) developed after hand suturing but none after LigaSure sealing. Amylase and lipase levels in drainage fluid were higher in the suture group during the first postoperative days but showed no differences after the fourth day. All but two animals that had to be euthanized because of small bowel invagination survived until POD 7. No significant differences were found in macroscopic changes between groups at reexploration. Histology demonstrated focal, chronic granulating inflammation with minor necrosis in all animals.

Conclusions

The LigaSure sealing device provides a safe alternative to conventional hand-sewn closure of the pancreatic stump in distal pancreatectomy. This is the first study that investigated this effective and highly applicable technique for pancreatic transection.

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Title: LigaSure for Pancreatic Sealing During Distal Pancreatectomy
Authors: Werner Hartwig
Martin Duckheim
Oliver Strobel
Dmitry Dovzhanskiy
Frank Bergmann
Thilo Hackert
Markus W. Büchler
Jens Werner
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 5/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0458-8

At a glance: The STEP trials

Springer Medicine

LigaSure for Pancreatic Sealing During Distal Pancreatectomy

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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