Skip to main content
Top
Published in: Breast Cancer 5/2018

01-09-2018 | Review Article

Life quality of patients who underwent breast reconstruction after prophylactic mastectomy: systematic review

Authors: Dilek Aygin, Hande Cengiz

Published in: Breast Cancer | Issue 5/2018

Login to get access

Abstract

Background

Prophylactic mastectomy is used to reduce the incidence of breast cancer in women with genetic predisposition and family history of breast cancer, and the rate of application is increased nowadays. Chronic pain, body image, and sexuality may negatively affect quality of life, while patients generally have increased quality of life and satisfaction after prophylactic mastectomy. The aim of this study is the evaluation of the results of the studies about quality of life of patients who underwent breast reconstruction after prophylactic mastectomy.

Methods

For the 1996–2016 literature, we searched the databases of Scopus, Science Direct, PubMed, EBSCO, Cochrane, Medline Complete, Ovid, Springer Link, Google Academic, Taylor & Francis, PsychINFO databases. For the gray literature, National Thesis Center and ULAKBIM databases were searched. Seven studies complying with the criteria were included in the review.

Results

Seven studies included in this study aimed to investigate the effect of prophylactic mastectomy on breast pain, numbness, sexuality and quality of life. When the studies were reviewed, we were found that the majority of the patients were satisfied with the results of the procedure, although the body image perception and pain/ movement/ perception and sexual problems were experienced after the breast surgery.

Conclusions

While overall satisfaction with cosmetic results was high, most women were not satisfied with the softness of the reconstructed breasts, and had problems with breast hardness, numbness and sex. Therefore, it is very important to inform the patients about the complications that may develop after the operation, while there is not enough data about the importance of informing the patients before the operation.
Literature
3.
go back to reference Serel S, Elçin SA, Çerkez C, Can Z, Gültan S. Breast reconstruction in prophylactic mastectomy. J Ankara Univ Fac Med. 2013;66(3):119–23. Serel S, Elçin SA, Çerkez C, Can Z, Gültan S. Breast reconstruction in prophylactic mastectomy. J Ankara Univ Fac Med. 2013;66(3):119–23.
4.
go back to reference Eser E. Health related quality of Life. Surgical care and quality of life symposium. Surgical care and quality of life symposium book (2012), pp. 2–4. Eser E. Health related quality of Life. Surgical care and quality of life symposium. Surgical care and quality of life symposium book (2012), pp. 2–4.
7.
go back to reference Koslow S, Pharmer LA, Scott AM, Stempel M, Morrow M, Pusic AL, King TA. Long-term patient reported satisfaction after contralateral prophylactic mastectomy and implant reconstruction. Ann Surg Oncol. 2013;20:3422–9.CrossRefPubMed Koslow S, Pharmer LA, Scott AM, Stempel M, Morrow M, Pusic AL, King TA. Long-term patient reported satisfaction after contralateral prophylactic mastectomy and implant reconstruction. Ann Surg Oncol. 2013;20:3422–9.CrossRefPubMed
8.
go back to reference Isern AE, Tengrup I, Loman N, Olsson H, Ringberg A. Aesthetic outcome, patient satisfaction, and health-related quality of life in women at high risk undergoing prophylactic mastectomy and immediate breast reconstruction. J Plast Reconstr Aesthet Surg. 2008;61:1177–87.CrossRefPubMed Isern AE, Tengrup I, Loman N, Olsson H, Ringberg A. Aesthetic outcome, patient satisfaction, and health-related quality of life in women at high risk undergoing prophylactic mastectomy and immediate breast reconstruction. J Plast Reconstr Aesthet Surg. 2008;61:1177–87.CrossRefPubMed
9.
go back to reference Brandberg Y, Sandelin K, Erikson S, Jurell G, Liljegren A, Lindblom A, Linden A, Wachenfeldt AV, Wickman M, Arver B. Psychological reactions, quality of life, and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: a prospective 1-year follow-up study. J Clin Oncol. 2008;26(24):3943–9.CrossRefPubMed Brandberg Y, Sandelin K, Erikson S, Jurell G, Liljegren A, Lindblom A, Linden A, Wachenfeldt AV, Wickman M, Arver B. Psychological reactions, quality of life, and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: a prospective 1-year follow-up study. J Clin Oncol. 2008;26(24):3943–9.CrossRefPubMed
10.
go back to reference Gahm J, Wickman M, Brandberg Y. Bilateral prophylactic mastectomy in women with inherited risk of breast cancer—prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery. Breast. 2010;19:462–9.CrossRefPubMed Gahm J, Wickman M, Brandberg Y. Bilateral prophylactic mastectomy in women with inherited risk of breast cancer—prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery. Breast. 2010;19:462–9.CrossRefPubMed
11.
go back to reference Frost MH, Hoskin TL, Hartmann LC, Degnim AC, Johnson JL, Boughey JC. Contralateral prophylactic mastectomy: long-term consistency of satisfaction and adverse effects and the significance of informed decision-making, quality of life, and personality traits. Ann Surg Oncol. 2011;18:3110–6.CrossRefPubMedPubMedCentral Frost MH, Hoskin TL, Hartmann LC, Degnim AC, Johnson JL, Boughey JC. Contralateral prophylactic mastectomy: long-term consistency of satisfaction and adverse effects and the significance of informed decision-making, quality of life, and personality traits. Ann Surg Oncol. 2011;18:3110–6.CrossRefPubMedPubMedCentral
12.
go back to reference Brandberg Y, Arver B, Johansson H, Wickman M, Sandelin K, Liljegren A. Less correspondence between expectations before and cosmetic results after risk-reducing mastectomy in women who are mutation carriers: a prospective study. Eur J Surg Oncol. 2012; 38(1):38–43.CrossRefPubMed Brandberg Y, Arver B, Johansson H, Wickman M, Sandelin K, Liljegren A. Less correspondence between expectations before and cosmetic results after risk-reducing mastectomy in women who are mutation carriers: a prospective study. Eur J Surg Oncol. 2012; 38(1):38–43.CrossRefPubMed
13.
go back to reference Gopie JP, Mureau MAM, Seynaeve C, Kuile MM, Menke-Pluymers MBE, Timman R, Tibben A. Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary. Breast Cancer Fam Cancer. 2013;12:479–87.CrossRefPubMed Gopie JP, Mureau MAM, Seynaeve C, Kuile MM, Menke-Pluymers MBE, Timman R, Tibben A. Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary. Breast Cancer Fam Cancer. 2013;12:479–87.CrossRefPubMed
14.
go back to reference Wasteson E, Sandelın K, Brandberg Y, Wıckman M, Arver B. High satisfaction rate ten years after bilateral prophylactic mastectomy—a longitudinal study. Eur J Cancer Care. 2011;20:508–13.CrossRef Wasteson E, Sandelın K, Brandberg Y, Wıckman M, Arver B. High satisfaction rate ten years after bilateral prophylactic mastectomy—a longitudinal study. Eur J Cancer Care. 2011;20:508–13.CrossRef
15.
go back to reference Boughey JC, Hoskin TL, Hartmann LC, Johnson JL, Jacobson SR, Degnim AC, Frost MH. Impact of reconstruction and reoperation on long-term patient-reported satisfaction after contralateral prophylactic mastectomy. Ann Surg Oncol. 2015; 22 (2): 401–8.CrossRefPubMed Boughey JC, Hoskin TL, Hartmann LC, Johnson JL, Jacobson SR, Degnim AC, Frost MH. Impact of reconstruction and reoperation on long-term patient-reported satisfaction after contralateral prophylactic mastectomy. Ann Surg Oncol. 2015; 22 (2): 401–8.CrossRefPubMed
16.
go back to reference Metcalfe KA, Esplen MJ, Goel V, Narod SA. Psychosocıal functioning in women who have undergone bilateral prophylactic mastectomy. Psycho-Oncol. 2004;13:14–25.CrossRef Metcalfe KA, Esplen MJ, Goel V, Narod SA. Psychosocıal functioning in women who have undergone bilateral prophylactic mastectomy. Psycho-Oncol. 2004;13:14–25.CrossRef
17.
go back to reference Geiger AM, Nekhlyudov L, Herrinton LJ, Rolnick SJ, Greene SM, West CN, Harris EL, Elmore JG, Altschuler A,, Fletcher SW, Emmons KM. Liu IL. Quality of life after bilateral prophylactic mastectomy. Ann Surg Oncol. 2007;14(2):686–94.CrossRefPubMed Geiger AM, Nekhlyudov L, Herrinton LJ, Rolnick SJ, Greene SM, West CN, Harris EL, Elmore JG, Altschuler A,, Fletcher SW, Emmons KM. Liu IL. Quality of life after bilateral prophylactic mastectomy. Ann Surg Oncol. 2007;14(2):686–94.CrossRefPubMed
18.
go back to reference Liu C, Zhuang Y, Momeni A, Luan J, Chung MT, Wright E, Lee GK. Quality of life and patient satisfaction after microsurgical abdominal flap versus staged expander/implant breast reconstruction: a critical study of unilateral immediate breast reconstruction using patient-reported outcomes instrument BREAST-Q. Breast Cancer Res Treat. 2014;146:117–26.CrossRefPubMed Liu C, Zhuang Y, Momeni A, Luan J, Chung MT, Wright E, Lee GK. Quality of life and patient satisfaction after microsurgical abdominal flap versus staged expander/implant breast reconstruction: a critical study of unilateral immediate breast reconstruction using patient-reported outcomes instrument BREAST-Q. Breast Cancer Res Treat. 2014;146:117–26.CrossRefPubMed
19.
go back to reference Unukovych D, Johansson H, Johansson E, Arver B, Liljegren A, Brandberg Y. Physical therapy after prophylactic mastectomy with breast reconstruction: A prospective randomized study. Breast. 2014;23:357–63.CrossRefPubMed Unukovych D, Johansson H, Johansson E, Arver B, Liljegren A, Brandberg Y. Physical therapy after prophylactic mastectomy with breast reconstruction: A prospective randomized study. Breast. 2014;23:357–63.CrossRefPubMed
20.
go back to reference Heiniger L, Butow PN, Coll J, Bullen T, Wilson J, Baylock B, Meiser B, Price MA. Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer. Fam Cancer. 2015;14:105–15.CrossRefPubMed Heiniger L, Butow PN, Coll J, Bullen T, Wilson J, Baylock B, Meiser B, Price MA. Long-term outcomes of risk-reducing surgery in unaffected women at increased familial risk of breast and/or ovarian cancer. Fam Cancer. 2015;14:105–15.CrossRefPubMed
21.
go back to reference Geiger AM, West CN, Nekhlyudov L, Herrinton LJ, Liu ILA, Altschuler A, Rolnick SJ, Harris EL, Greene SM, Elmore JG, Emmons KM, Fletcher SW. Contentment with quality of life among breast cancer survivors with and without contralateral prophylactic mastectomy. J Clin Oncol. 2006;24(9):1350–6.CrossRefPubMed Geiger AM, West CN, Nekhlyudov L, Herrinton LJ, Liu ILA, Altschuler A, Rolnick SJ, Harris EL, Greene SM, Elmore JG, Emmons KM, Fletcher SW. Contentment with quality of life among breast cancer survivors with and without contralateral prophylactic mastectomy. J Clin Oncol. 2006;24(9):1350–6.CrossRefPubMed
Metadata
Title
Life quality of patients who underwent breast reconstruction after prophylactic mastectomy: systematic review
Authors
Dilek Aygin
Hande Cengiz
Publication date
01-09-2018
Publisher
Springer Japan
Published in
Breast Cancer / Issue 5/2018
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-018-0862-8

Other articles of this Issue 5/2018

Breast Cancer 5/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine