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01-12-2012 | Original Article

Lidocaine containing high concentrations of a vasoconstrictor: is it safe for infiltration anesthesia?

Authors: Nasser Vesal, Alireza Raayat Jahromi, Ahmad Oryan

Published in: Comparative Clinical Pathology | Issue 6/2012

Abstract

For economical and practical reasons, flank laparotomy performed on cattle is done while the animal is standing. To prolong the duration of surgical anesthesia with local anesthetic drugs, vasoconstrictors are commonly added to delay absorption and reduce the systemic toxicity. The purpose of this study was to examine the effects of lidocaine containing either 80 μg ml^-1 norepinephrine or 12.5 μg ml^-1 epinephrine on tissue integrity following flank inverted L infiltration anesthesia in sheep.

Results of histologic examination of the skin and subcutaneous tissue sections by light microscopy showed significant pathologic changes (inflammatory changes and necrosis) of the epidermis and dermis in sheep receiving lidocaine containing 80 μg ml^-1 norepinephrine. Because of the potential for skin and muscle necrosis and injection site inflammation, lidocaine with a high concentration of a vasoconstrictor is not recommended for infiltration anesthesia.

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Title: Lidocaine containing high concentrations of a vasoconstrictor: is it safe for infiltration anesthesia?
Authors: Nasser Vesal
Alireza Raayat Jahromi
Ahmad Oryan
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Comparative Clinical Pathology / Issue 6/2012
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-011-1352-y

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Lidocaine containing high concentrations of a vasoconstrictor: is it safe for infiltration anesthesia?

Abstract

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