Published in:
01-04-2001 | Adis New Drug Profile
Levosimendan
A Viewpoint by Markku S. Nieminen
Author:
Markku S. Nieminen
Published in:
Drugs
|
Issue 5/2001
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Excerpt
Calcium sensitising has been proposed as the best way to improve deteriorating cardiac cell function in heart failure. However, it has proven difficult to develop agents which have a safe mode of action. To date, most agents evaluated in clinical trials also possess phosphodiesterase III and IV inhibitory activity, which may account for their adverse effects. …