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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-08-2015 | Retinal Disorders

Level of vitreous alpha-B crystallin in eyes with rhegmatogenous retinal detachment

Authors: Takayuki Baba, Toshiyuki Oshitari, Shuichi Yamamoto

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 8/2015

Abstract

Purpose

Alpha-B crystallin (αB-crystallin) is a molecular chaperone, and one of the small heat shock proteins (sHSPs). αB-crystallin has been shown to have neuroprotective properties. The purpose of this study was to determine the level of αB-crystallin in eyes with a rhegmatogenous retinal detachment (RRD).

Methods

Vitreous samples were collected before vitrectomy from 32 eyes of 32 consecutive patients with RRD. The concentration of αB-crystallin was measured by enzyme-linked immunosorbent assay (ELISA). Vitreous samples were also collected before vitrectomy from 16 patients with an idiopathic macular hole and epiretinal membrane, and used as controls.

Results

The mean age was 56 years (range, 31–67 years) in the RRD cases and 66 years (range, 49–77 years) in the controls. The mean level of αB-crystallin was significantly higher in the RRD cases (36.7 ± 37.4 ng/ml) than that in controls (8.5 ± 12.2 ng/ml; P = 0.0028).

Conclusions

The increased level of αB-crystallin suggests that αB-crystallin may play a neuroprotective role by lessening retinal cell death after a retinal detachment.

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Title: Level of vitreous alpha-B crystallin in eyes with rhegmatogenous retinal detachment
Authors: Takayuki Baba
Toshiyuki Oshitari
Shuichi Yamamoto
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 8/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-014-2815-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Level of vitreous alpha-B crystallin in eyes with rhegmatogenous retinal detachment

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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